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dc.contributor.authorMalatyali, E.
dc.contributor.authorTepe, B.
dc.contributor.authorDegerli, S.
dc.contributor.authorBerk, S.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:40Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:40Z
dc.date.issued2012
dc.identifier.issn0932-0113
dc.identifier.urihttps://dx.doi.org/10.1007/s00436-011-2744-2
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9114
dc.descriptionWOS: 000304627300011en_US
dc.descriptionPubMed ID: 22160280en_US
dc.description.abstractAmoebic keratitis is difficult to treat without total efficacy in some patients because of cysts, which are less susceptible than trophozoites to the usual treatments. The aim of this study is to evaluate the in vitro amoebicidal activity of the methanolic extracts of Satureja cuneifolia and Melissa officinalis. In the presence of methanolic extracts (ranging from 1.0 to 32.0 mg/ml), numbers of the viable Acanthamoe castellanii trophozoites and cysts were decreased during the experimental process. Both extracts showed a time- and dose-dependent amoebicidal action on the trophozoites and cysts. Among the extracts tested, S. cuneifolia showed the strongest amoebicidal effect on the trophozoites and cysts. In the presence of 32 mg/ml extract, no viable trophozoites were observed within 24 h. At the same concentration value, the extract was found effective against the cysts at a rate of 46.3% within 72 h of the experimental process. At 16 mg/ml extract concentration, no viable trophozoites were also observed in the 24th hour of the experiment. At the end of the experimental process, 34.7% of the cysts were killed by the extract. M. officinalis showed moderate amoebicidal effect. At the concentration of 32 mg/ml, 44.3% and 30.0% of the trophozoites and cysts were killed by the extract, respectively. Results obtained from these concentration values were found statistically different in terms of their actions both on trophozoites and cysts (p < 0.05).en_US
dc.description.sponsorshipResearch Council of Cumhuriyet University (CUBAP), Sivas, Turkey [F-346]en_US
dc.description.sponsorshipThis study is financially supported by the Research Council of Cumhuriyet University (CUBAP), Sivas, Turkey with the project number F-346.en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.relation.isversionof10.1007/s00436-011-2744-2en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleIn vitro amoebicidal activities of Satureja cuneifolia and Melissa officinalis on Acanthamoeba castellanii cysts and trophozoitesen_US
dc.typearticleen_US
dc.relation.journalPARASITOLOGY RESEARCHen_US
dc.contributor.department[Malatyali, E. -- Degerli, S.] Cumhuriyet Univ, Sch Med, Dept Parasitol, TR-58140 Sivas, Turkey -- [Tepe, B. -- Berk, S.] Cumhuriyet Univ, Fac Sci & Literature, Dept Mol Biol & Genet, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDTEPE, Bektas -- 0000-0001-8982-5188en_US
dc.identifier.volume110en_US
dc.identifier.issue6en_US
dc.identifier.endpage2180en_US
dc.identifier.startpage2175en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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