Alterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas
dc.contributor.author | Kilinc, Devran | |
dc.contributor.author | Ozdemir, Oztuerk | |
dc.contributor.author | Ozdemir, Semra | |
dc.contributor.author | Korgali, Esat | |
dc.contributor.author | Koksal, Binnur | |
dc.contributor.author | Uslu, Atilla | |
dc.contributor.author | Gultekin, Yener E. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:46Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:46Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1044-5498 | |
dc.identifier.uri | https://dx.doi.org/10.1089/dna.2011.1431 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9143 | |
dc.description | WOS: 000304312300028 | en_US |
dc.description | PubMed ID: 22136354 | en_US |
dc.description.abstract | Hypermethylated genomic DNA is a common feature in tumoral tissues, although the prevalence of this modification remains poorly understood. We aimed to determine the frequency of five tumor suppressor (TS) genes in prostate cancer and the correlation between promoter hypermethylation of these genes and low and high grade of prostate carcinomas. A total of 30 prostate tumor specimens were investigated for promoter methylation status of TS hypermethylated in cancer 1 (HIC1), death-associated protein kinase 1 (DAPK1), secreted frizzled-related protein 2 (SFRP2), cyclin-dependent kinase inhibitor 2A (p16), and O-6-methylguanine-DNA methyltransferase (MGMT) genes by using bisulfite modifying method. A high frequency of promoter hypermethylation was found in HIC1 (70.9%), SFRP2 (58.3%), and DAPK1 (33.3%) genes in tumor samples that were examined. The current data show high frequency of hypermethylation changes in HIC1, SFRP2, and DAPK1 genes in prostate carcinomas of high Gleason Score (GS). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MARY ANN LIEBERT INC | en_US |
dc.relation.isversionof | 10.1089/dna.2011.1431 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Alterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas | en_US |
dc.type | article | en_US |
dc.relation.journal | DNA AND CELL BIOLOGY | en_US |
dc.contributor.department | [Ozdemir, Oztuerk] Canakkale Onsekiz Mart Univ, Dept Med Genet, Fac Med, TR-17100 Canakkale, Turkey -- [Kilinc, Devran -- Korgali, Esat -- Gultekin, Yener E.] Cumhuriyet Univ, Dept Urol, Fac Med, Sivas, Turkey -- [Ozdemir, Oztuerk -- Koksal, Binnur] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey -- [Ozdemir, Semra] Canakkale Onsekiz Mart Univ, Dept Nucl Med, Fac Med, TR-17100 Canakkale, Turkey -- [Uslu, Atilla] Istanbul Univ, Dept Physiol, Fac Med, Istanbul, Turkey | en_US |
dc.contributor.authorID | Korgali, Esat -- 0000-0003-0318-0353 | en_US |
dc.identifier.volume | 31 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 832 | en_US |
dc.identifier.startpage | 826 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
This item appears in the following Collection(s)
-
Makale Koleksiyonu [5200]
Article Collection -
Makale Koleksiyonu [5745]
Article Collection -
Öksüz Yayınlar Koleksiyonu - WoS [6162]