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dc.contributor.authorDegerli, Serpil
dc.contributor.authorTepe, Bektas
dc.contributor.authorCeliksoz, Ali
dc.contributor.authorBerk, Seyda
dc.contributor.authorMalatyali, Erdogan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:50Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:50Z
dc.date.issued2012
dc.identifier.issn0014-4894
dc.identifier.urihttps://dx.doi.org/10.1016/j.exppara.2012.02.020
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9162
dc.descriptionWOS: 000303956100003en_US
dc.descriptionPubMed ID: 22417972en_US
dc.description.abstractIn some patients, complete treatment of amoebic keratitis is difficult because of the resistance of cysts to therapeutic agents. The aim of this study was to evaluate the in vitro amoebicidal activity of methanolic extracts of Origanum syriacum and Origanum laevigatum. In the presence of methanolic extracts (ranging from 1.0 to 32.0 mg/ml), numbers of the viable Acanthamoeba castellanii trophozoites and cysts were decreased. Both extracts showed a time and dose dependent amoebicidal action on the trophozoites and cysts. Of the extracts tested, O. syriacum showed the stronger amoebicidal effect on the trophozoites and cysts. In the presence of 32 mg/ml extract, no viable trophozoites were observed within third hour. The extract was also found effective against the cysts within 24th hour. In the case of O. laevigatum, no viable trophozoites were observed within 72nd hour at the concentrations of 16 and 32 mg/ml. As expected, cysts were found more resistant to the extracts than the trophozoites. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.isversionof10.1016/j.exppara.2012.02.020en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOriganum syriacumen_US
dc.subjectOriganum laevigatumen_US
dc.subjectAmoebicidal activityen_US
dc.subjectAcanthamoeba castellaniien_US
dc.subjectTrophozoiteen_US
dc.subjectCysten_US
dc.titleIn vitro amoebicidal activity of Origanum syriacum and Origanum laevigatum on Acanthamoeba castellanii cysts and trophozoitesen_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL PARASITOLOGYen_US
dc.contributor.department[Tepe, Bektas -- Berk, Seyda] Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci & Literature, TR-58140 Sivas, Turkey -- [Degerli, Serpil -- Celiksoz, Ali -- Malatyali, Erdogan] Cumhuriyet Univ, Sch Med, Dept Microbiol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDTEPE, Bektas -- 0000-0001-8982-5188en_US
dc.identifier.volume131en_US
dc.identifier.issue1en_US
dc.identifier.endpage24en_US
dc.identifier.startpage20en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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