Comparison of the antiangiogenic effects of heparin sodium, enoxaparin sodium, and tinzaparin sodium by using chorioallantoic membrane assay
Date
2012Author
Katrancioglu, NurkayKarahan, Oguz
Kilic, Ahmet Turhan
Altun, Ahmet
Katrancioglu, Ozgur
Polat, Zubeyde Akin
Metadata
Show full item recordAbstract
Unfractionated heparin (UFH) and low molecular weight heparins have been used as anticoagulation agents in cardiovascular clinics for decades. However, these molecules also have potent antiangiogenic effects. Whereas, angiogenesis may be the most crucial determinant of the prognosis of cardiovascular diseases, and except some special situation, antiangiogenic effect is not desirable in the most of the cardiovascular disease. In this study, we aimed to compare the antiangiogenic potency of UFH, enoxaparin, and tinzaparin. The antiangiogenic efficacies of UFH, enoxaparin, and tinzaparin were examined in vivo by using the chick chorioallantoic membrane (CAM) model. Twenty fertilized eggs were used for each studied drug. Drug solutions were prepared in 10 and 1 IU/10 mu l concentrations. Decreases in the density of the capillaries were assessed and scored. All three drugs showed antiangiogenic effects on the chick CAM at the 10 IU/10 mu l concentration. However, the antiangiogenic score of the UFH was significantly higher than that of enoxaparin and tinzaparin at 1 and 10 IU/10 mu l concentrations. UFH had stronger and antiangiogenic potential than enoxaparin and tinzaparin. However, tinzaparin showed dose-dependent antiangiogenic effects. We think that an anticoagulant molecule with a less and dose-dependent antiangiogenic effect, as in the case of tinzaparin, may be more desirable in case of cardiovascular disease related with insufficient angiogenesis. Blood Coagul Fibrinolysis 23: 218-221 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Source
BLOOD COAGULATION & FIBRINOLYSISVolume
23Issue
3Collections
- Makale Koleksiyonu [5200]
- Makale Koleksiyonu [5745]
- Öksüz Yayınlar Koleksiyonu - WoS [6162]
Related items
Showing items related by title, author, creator and subject.
-
Antiangiogenic activities of bemiparin sodium, enoxaparin sodium, nadroparin calcium and tinzaparin sodium
Dogan, Omer Tamer; Polat, Zubeyde Akin; Karahan, Oguz; Epozturk, Kursat; Altun, Ahmet; Akkurt, Ibrahim; Cetin, Ali (PERGAMON-ELSEVIER SCIENCE LTD, 2011)Introduction: The low-molecular-weight heparins have been demonstrated to have antiangiogenic effects in various assays. We aimed to demonstrate and compare the antiangiogenic effects of four types of commercially available ... -
A COMPARISON OF THE EFFECTS OF ENOXAPARIN SODIUM AND N-ACETYL CYSTEINE ON OVARIAN TORSION: AMH AND FOLLICLE COUNTS.
Ersoy, G. Sahin; Eken, M.; Cevik, O.; Cilingir, O. (ELSEVIER SCIENCE INC, 2015)… -
Thrombocyte sodium-potassium ATPase activity in children with insulin-dependent diabetes mellitus
Törel Ayça Ergür; Öge Çetinkaya; Yavuz Siliğ (2000)İnsüline bağımlı diabetes mellitus(IDDM), vücutta çeşitli sistemler üzerinde olumsuz etkileri bulunan ciddi metabolik bir hastalıktır.Son yıllarda hematolojik sistem üzerinde yarattığı etkiler konusundaki araştırmalar hız ...