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Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases

Date

2012

Author

Kaya, Ali
Deveci, Koksal
Uysal, Ismail Onder
Guven, Ahmet Sami
Demir, Mevlut
Uysal, Elif Bilge
Gultekin, Asim
Icagasioglu, Fusun Dilara

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Abstract

Kaya A, Deveci K, Uysal IO, Guven AS, Demir M, Uysal EB, Gultekin A, Icagasioglu FD. Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases. Mirk J Pediatr 2012; 54: 105-112. Tularemia is a zoonotic disease caused by Francisella tularensis. We aimed to explicate the clinical and laboratory findings of 27 consecutive tularemia patients who were included into the study. The average duration between onset of symptoms and diagnosis was 19.1 +/- 7.3 days. Sore throat (100%), fever (93%) and myalgia (100%) were the most frequently observed symptoms, while lymphadenopathy (100%), pharyngeal hyperemia (85%), tonsillitis (74%), and rash (7%) were the most frequently observed physical findings. Treatment failed in 6 patients: 1/13 streptomycin- (changed to doxycycline + streptomycin), 1/7 ciprofloxacin- (changed to streptomycin), and 4/7 gentamicin- (changed to streptomycin) receiving patients who had longer duration to treatment (26.5 +/- 2.9 days) than the 21 successfully treated cases (17.0 +/- 6.8 days). Tularemia should to be taken into account in the differential diagnosis in cases having tonsillopharyngitis and cervical lymphadenopathy without response to beta lactam/macrolide-group antibiotics in rural areas. We believe that streptomycin should be the first-line antibiotic in the treatment of pediatric tularemia cases, but it should be supported by comprehensive studies with larger patient series.

Source

TURKISH JOURNAL OF PEDIATRICS

Volume

54

Issue

2

URI

https://hdl.handle.net/20.500.12418/9213

Collections

  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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