Effects of boric acid on experimental periodontitis and alveolar bone loss in rats
dc.contributor.author | Demirer, Serhat | |
dc.contributor.author | Kara, M. Isa | |
dc.contributor.author | Erciyas, Kamile | |
dc.contributor.author | Ozdemir, Hakan | |
dc.contributor.author | Ozer, Hatice | |
dc.contributor.author | Ay, Sinan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:04:38Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:04:38Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0003-9969 | |
dc.identifier.issn | 1879-1506 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.archoralbio.2011.07.012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9362 | |
dc.description | WOS: 000300122800009 | en_US |
dc.description | PubMed ID: 21871607 | en_US |
dc.description.abstract | Objective: The goal of the present study was to evaluate the histopathologic and morphometric effects of systemic boric acid in a rat periodontitis model. Design: Twenty-four Wistar rats were divided into three groups of eight animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3 mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the mandibular first molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups. Results: The ratio of presence of inflammatory cell infiltration (ICI) and osteoclast number in the LO group was significantly higher than that of the NL and BA groups (p < 0.05). The ratio of presence of osteoblastic activity in the LO group was significantly lower than that of the NL and BA groups (p < 0.05). Alveolar bone loss was also significantly higher in the LO group compared to the BA and NL groups (p < 005). Conclusions: This study has demonstrated that systemic administration of boric acid reduced periodontal inflammation and alveolar bone loss in periodontal disease in rats. (C) 2011 Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.isversionof | 10.1016/j.archoralbio.2011.07.012 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Experimental periodontitis | en_US |
dc.subject | Rat | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Antioxidant | en_US |
dc.title | Effects of boric acid on experimental periodontitis and alveolar bone loss in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | ARCHIVES OF ORAL BIOLOGY | en_US |
dc.contributor.department | [Kara, M. Isa] Izmir Katip Celebi Univ, Dept Oral & Maxillofacial Surg, Fac Dent, TR-34180 Izmir, Turkey -- [Demirer, Serhat] Kirikkale Univ, Dept Periodontol, Fac Dent, Kirikkale, Turkey -- [Erciyas, Kamile] Gaziantep Univ, Dept Periodontol, Fac Dent, Gaziantep, Turkey -- [Ozdemir, Hakan] Cumhuriyet Univ, Dept Periodontol, Fac Dent, Sivas, Turkey -- [Ozer, Hatice] Cumhuriyet Univ, Dept Pathol, Fac Med, Sivas, Turkey -- [Ay, Sinan] Gaziantep Univ, Dept Oral & Maxillofacial Surg, Fac Dent, Gaziantep, Turkey | en_US |
dc.identifier.volume | 57 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 65 | en_US |
dc.identifier.startpage | 60 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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