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dc.contributor.authorSaraydin, Serpil Unver
dc.contributor.authorTuncer, Ersin
dc.contributor.authorTepe, Bektas
dc.contributor.authorKaradayi, Sule
dc.contributor.authorOzer, Hatice
dc.contributor.authorSen, Metin
dc.contributor.authorKaradayi, Kursat
dc.contributor.authorInan, Deniz
dc.contributor.authorElagoz, Sahande
dc.contributor.authorPolat, Zubeyde
dc.contributor.authorDuman, Mustafa
dc.contributor.authorTuran, Mustafa
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:04:42Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:04:42Z
dc.date.issued2012
dc.identifier.issn1513-7368
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2012.13.6.2765
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9378
dc.descriptionWOS: 000309472300058en_US
dc.descriptionPubMed ID: 22938456en_US
dc.description.abstractBackground: There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. Here we investigated the antiproliferative properties of Melissa officinalis (MO) from Turkey on breast cancer. Methods: MO extracts were studied for cytotoxicity against breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231). In vitro apoptosis studies were performed by annexin V staining and flow cytometry analyses. Immunohistochemistry for Ki-67 and caspase 7 in the tumoral tissue sections of DMBA-induced mammary tumors in rats was also performed, along with TUNEL assays to detect apoptotic cells. In vivo anticancer activity testing was carried out with reference to inhibition of growth of DMBA induced mammary tumors in rats. Results: MO showed cytotoxicity against three cancer cell lines, inducing increase in Annexin-positive cells. Expression of caspase-7 protein and TUNEL positive cells were much higher in rats treated by MO, compared with the untreated control group, while expression of Ki-67 was decreased. Furthermore, in vivo studies showed that mean tumor volume inhibition ratio in MO treated group was 40% compared with the untreated rats. Conclusion: These results indicated that MO extrcts have antitumoral potential against breast cancer.en_US
dc.description.sponsorshipCumhuriyet University [T-383]en_US
dc.description.sponsorshipThis work has been supported by the Scientific Research Project Fund of Cumhuriyet University under the project number T-383. The authors have declared that there is no conflict of interest.en_US
dc.language.isoengen_US
dc.publisherASIAN PACIFIC ORGANIZATION CANCER PREVENTIONen_US
dc.relation.isversionof10.7314/APJCP.2012.13.6.2765en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelissa officinalisen_US
dc.subjectbreast canceren_US
dc.subjectantitumoral effectsen_US
dc.titleAntitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivoen_US
dc.typearticleen_US
dc.relation.journalASIAN PACIFIC JOURNAL OF CANCER PREVENTIONen_US
dc.contributor.department[Sen, Metin -- Karadayi, Kursat -- Turan, Mustafa] Cumhuriyet Univ, Fac Med, Dept Gen Surg, Sivas, Turkey -- [Saraydin, Serpil Unver -- Inan, Deniz] Cumhuriyet Univ, Fac Med, Dept Histol & Embryol, Sivas, Turkey -- [Tuncer, Ersin -- Ozer, Hatice -- Elagoz, Sahande] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Tepe, Bektas] Cumhuriyet Univ, Fac Med, Dept Mol Biol & Genet, Sivas, Turkey -- [Karadayi, Sule] Cumhuriyet Univ, Fac Med, Dept Thorac Surg, Sivas, Turkey -- [Polat, Zubeyde] Cumhuriyet Univ, Fac Med, Dept Parasitol, Sivas, Turkey -- [Duman, Mustafa] Kosuyolu Educ & Res Hosp, Istanbul, Turkeyen_US
dc.contributor.authorIDTEPE, Bektas -- 0000-0001-8982-5188;en_US
dc.identifier.volume13en_US
dc.identifier.issue6en_US
dc.identifier.endpage2770en_US
dc.identifier.startpage2765en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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