dc.contributor.author | Ocal, Pelin | |
dc.contributor.author | Sahmay, Sezai | |
dc.contributor.author | Cetin, Meral | |
dc.contributor.author | Irez, Tulay | |
dc.contributor.author | Guralp, Onur | |
dc.contributor.author | Cepni, Ismail | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:04:48Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:04:48Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1058-0468 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s10815-011-9627-4 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9396 | |
dc.description | WOS: 000298228400011 | en_US |
dc.description | PubMed ID: 21882017 | en_US |
dc.description.abstract | Objective To evaluate predictive role of day-3 serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles. Materials and methods Forty-one women with moderate/severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E(2), FSH, LH, AMH, inhibin-B levels measured on day 3 of the menstrual cycle before controlled ovarian hyperstimulation. Results Mean FSH was significantly lower (p < 0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p = 0.049, p < 0.0001 and p < 0.0001, respectively). There was no significant difference in inhibin B (p = 0.112) and estradiol (p = 0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC = 0.87) and AFC (AUC = 0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC = 0.58) and LH (AUC = 0.61) had low accuracy. The cut-off value for AMH 3.3 ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV. Conclusion Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | en_US |
dc.relation.isversionof | 10.1007/s10815-011-9627-4 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antimullerian hormone | en_US |
dc.subject | Ovarian hyperstimulation syndrome | en_US |
dc.subject | Antral follicle count | en_US |
dc.title | Serum anti-Mullerian hormone and antral follicle count as predictive markers of OHSS in ART cycles | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | en_US |
dc.contributor.department | [Ocal, Pelin] Istanbul Univ, Cerrahpasa Tip Fak, Fatih Istanbul, Turkey -- [Ocal, Pelin -- Sahmay, Sezai -- Irez, Tulay -- Guralp, Onur -- Cepni, Ismail] Istanbul Univ, Cerrahpasa Med Sch, Dept Obstet & Gynecol, IVF Unit, Fatih Istanbul, Turkey -- [Cetin, Meral] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey | en_US |
dc.contributor.authorID | Guralp, Onur -- 0000-0002-3517-3046; ocal, kutsiye pelin -- 0000-0002-7531-5942 | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.endpage | 1203 | en_US |
dc.identifier.startpage | 1197 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |