Fibroblast growth factor receptor 4 Gly388Arg polymorphism is not associated with pre-eclampsia in Turkish women

Abstract

Aim: The aim of this study was to assess the association between human fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism and pre-eclampsia (PE) by carrying out a casecontrol study in Turkish women. Materials and Methods: In the present study 159 PE patients and 161 controls were included. DNA was extracted from peripheral blood leukocyte and FGFR4 Gly388Arg polymorphism was investigated using polymerase chain reaction-restriction fragment length polymorphism methods. Results: For Gly388Arg polymorphism of FGFR4 we found no significant association between controls and PE patients. The frequencies of GlyGly, GlyArg and ArgArg genotypes were 56.6%, 36.4% and 7% for the study group and 50.3%, 44.7% and 5% for the control group, respectively. The risk of women with the GlyArg (odds ratio = 0.7, 95% confidence interval: 0.45-1.14) and ArgArg (odds ratio = 1.2, 95% confidence interval: 0.47-3.22) genotypes for PE did not differ significantly from that of GlyGly genotype carriers. Conclusion: As we could not find any association between genetic variability in Gly388Arg of FGFR4 and PE, this specific polymorphism of FGFR4 can be eliminated as a risk factor for PE at least for Turkish women.