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Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study

Date

2011

Author

Katrancioglu, Nurkay
Manduz, Sinasi
Ozen, Filiz
Yilmaz, Mehmet Birhan
Atahan, Erhan
Ozdemir, Ozturk
Berkan, Ocal

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Abstract

Materials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. Results: In the DVT group, E3/E4 gene polymorphism was detected in 20 patients (33.9%), in the control group E3/E4 polymorphism was detected in six patients (10.2%; P = .002). In the multivariable regression analysis, E3/E4 was independently associated with 1.31-fold increased risk of DVT (odds ratio [OR] 1.31; 95% confidence interval [CI], 1.30-10.48). Conclusion: It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies.

Source

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Volume

17

Issue

2

URI

https://dx.doi.org/10.1177/1076029609348646
https://hdl.handle.net/20.500.12418/9574

Collections

  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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