dc.contributor.author | Korkmaz, Serdal | |
dc.contributor.author | Yildiz, Gursel | |
dc.contributor.author | Kilicli, Fatih | |
dc.contributor.author | Yilmaz, Abdulkerim | |
dc.contributor.author | Aydin, Huseyin | |
dc.contributor.author | Icagasioglu, Serhat | |
dc.contributor.author | Candan, Ferhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:06:03Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:06:03Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 2149-2263 | |
dc.identifier.issn | 2149-2271 | |
dc.identifier.uri | https://dx.doi.org/10.5152/akd.2011.008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9614 | |
dc.description | WOS: 000287018600011 | en_US |
dc.description | PubMed ID: 21220248 | en_US |
dc.description.abstract | Objective: The nocturnal blood pressure (NBP) reduction is less than normal in the patients with type 2 diabetes mellitus (type 2 DM). L-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM. The purpose of the study was to investigate whether there is a difference in levels of L-carnitine in dipper and nondippers patients with type 2 DM. Methods: This is a cross-sectional observational cohort study. We compared the 50 (33 females, 17 males) patients with type 2 DM and the 35 healthy persons (18 females, 17 males) as a control group. In all cases, ambulatory blood pressure monitoring (ABPM) was performed and L-carnitine was measured. The independent samples t test, Chi-square test, Mann-Whitney U test and Pearson correlation analysis were used in the statistical evaluation of data. Results: We found that the percentage of nondipper pattern was 72% in patients with type 2 DM. L-carnitine levels were lower in patients with type 2 DM (52.77+/-12.34 mu mol/L) than those of control group (79.18+/-10.59 mu mol/L), and these differences were statistically significant (p<0.05). L-carnitine levels were lower in nondipper cases (50.02+/-16.30 mu mol/L) than those of dipper cases (53.83+/-10.50 mu mol/L), but these differences were not statistically significant (p=0.125). Conclusion: Nondipper pattern is common in patients with type 2 DM. Nondipper pattern is associated with damage of target organ. Therefore, determination of nondipper pattern by ABPM is very important. L-carnitine levels were found to be lower in nondipper patients than in dipper patients with type 2 DM. Although, these differences were statistically nonsignificant, more detailed studies should be performed to determine the frequencies and relationship between nondipper pattern and L-carnitine levels in patients with type-2 DM. (Anadolu Kardiyol Derg 2011 1: 57-63) | en_US |
dc.language.iso | tur | en_US |
dc.publisher | TURKISH SOC CARDIOLOGY | en_US |
dc.relation.isversionof | 10.5152/akd.2011.008 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Type 2 diabetes mellitus | en_US |
dc.subject | L-carnitine | en_US |
dc.subject | nocturnal blood pressure | en_US |
dc.subject | nondipper pattern | en_US |
dc.title | Low L-carnitine levels: Can it be a cause of nocturnal blood pressure changes in patients with toe 2 diabetes mellitus? | en_US |
dc.type | article | en_US |
dc.relation.journal | ANATOLIAN JOURNAL OF CARDIOLOGY | en_US |
dc.contributor.department | [Yildiz, Gursel] Cumhuriyet Univ, Nefrol Bilim Dali, Tip Fak, Sivas, Turkey -- [Korkmaz, Serdal] Gemerek Deviet Hastanesi, Ic Hastahklari Bolumu, Sivas, Turkey -- [Aydin, Huseyin] Cumhuriyet Univ, Klin Biyokimya Bilim Dallari, Tip Fak, Sivas, Turkey -- [Icagasioglu, Serhat] Cumhuriyet Univ, Ic Hastaliklari Anabilim Dali, Tip Fak, Sivas, Turkey | en_US |
dc.contributor.authorID | Korkmaz, Serdal -- 0000-0002-5759-2735 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 63 | en_US |
dc.identifier.startpage | 57 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |