dc.contributor.author | Nadir, Isilay | |
dc.contributor.author | Yonem, Ozlem | |
dc.contributor.author | Ozin, Yasemin | |
dc.contributor.author | Kilic, Zeki Mesut Yalin | |
dc.contributor.author | Sezgin, Orhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:06:04Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:06:04Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0038-4348 | |
dc.identifier.uri | https://dx.doi.org/10.1097/SMJ.0b013e318200c209 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9617 | |
dc.description | WOS: 000286460300009 | en_US |
dc.description | PubMed ID: 21206418 | en_US |
dc.description.abstract | Background: The prevalence of Helicobacter pylori (H pylori) in Turkey is high and eradication rates are low. As a result, alternative treatment strategies are required. Objectives: To evaluate the status of H pylori eradication in Turkey by comparing the results of this study to other studies reported in the literature. Methods: Two hundred and eighty-two patients diagnosed with H pylori were included in this study. Patients were randomized into two groups. The first group consisted of 138 patients receiving 30 mg lansoprazole bid, amoxicillin 1 g bid, and clarithromycin 500 mg bid for 14 days. The second group consisted of 144 patients who received lansoprazole 30 mg bid and amoxicillin 1 g bid for seven days, followed by metronidazole 500 mg bid, tetracycline 500 mg qid, and lansoprazole 30 mg bid for an additional seven days. Results: H pylori eradication rates in the first group were 53.6% according to intention-to-treat analysis, and 52.5% according to per protocol analysis. In the second group, eradication rates were 72.2% per intention-to-treat analysis and 77.6% as per protocol analysis. H pylori eradication rates in the second group were significantly higher than the first group (P = 0.001, P < 0.05), whereas the incidence of adverse events in the second group was significantly lower (P = 0.048, P < 0.05). Conclusion: This study found a significant difference in eradication rates between the traditional triple therapy and modified sequential therapy groups. As a result, modified sequential therapy shows promise as an alternative treatment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.isversionof | 10.1097/SMJ.0b013e318200c209 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Helicobacter pylori eradication | en_US |
dc.subject | modified sequential therapy | en_US |
dc.subject | non-ulcer dyspepsia | en_US |
dc.subject | standard triple therapy | en_US |
dc.title | Comparison of Two Different Treatment Protocols in Helicobacter pylori Eradication | en_US |
dc.type | article | en_US |
dc.relation.journal | SOUTHERN MEDICAL JOURNAL | en_US |
dc.contributor.department | [Nadir, Isilay] Sivas Numune Hosp, Dept Gastroenterol, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Gastroenterol, Sivas, Turkey -- Turkiye Yuksek Ihtisas Hosp, Dept Gastroenterol, Ankara, Turkey -- Mersin Univ, Sch Med, Dept Gastroenterol, Mersin, Turkey | en_US |
dc.identifier.volume | 104 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 105 | en_US |
dc.identifier.startpage | 102 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |