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dc.contributor.authorErsan, E. Erdal
dc.contributor.authorErsan, Serpil
dc.contributor.authorDogan, Orhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:06:23Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:06:23Z
dc.date.issued2011
dc.identifier.issn1302-6631
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9662
dc.descriptionWOS: 000291214300003en_US
dc.description.abstractObjective: Schizophrenia is a neuropsychiatric disease which affects individuals, family members and society. Although many studies have been carried out on the etiopathogenesis of schizophrenia, the condition is not entirely understood. In this study, it has been aimed to measure prostaglandin (PG) metabolite levels in patients with schizophrenia. Methods: The present study measured prostaglandin metabolite levels in 50 schizophrenia patients and 50 healthy volunteers who were matched for age, sex and smoking is similar in terms of, at least two years of patient. Measurements were also taken of 13,14-dihydro-15-keto-PGF(2 alpha) (PGFM) and 13,14-dihydro-15-keto PGE(2) (PGEM). The measurements were performed using High Performance Liquid Chromatography (HPLC) which is a more sensitive device. Statistical analysis of the data was performed using Student's t Test, Chi Square Test, Kruskal-Wallis Test and Mann-Whitney Test. Findings: In the patient group, the PGEM level (0.0807+/-0.014, t=3.490, p=0.001) and the PGFM level (0.0613+/-0.0128, t=-7.486, p=0.000) were both significantly lower than in the control group (PGEM 0.0907+/-0.0146; PGFM 0.0793+/-0.0113). Discussion: These results suggest that a disorder in phospholipid metabolism may be important in the etiopathogenesis of schizophrenia. (Anatolian Journal of Psychiatry 2011; 12:100-106)en_US
dc.language.isoturen_US
dc.publisherCUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALIen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfatty acidsen_US
dc.subjectphospholipid metabolismen_US
dc.subjectprostaglandinen_US
dc.subjectschizophreniaen_US
dc.titleProstaglandin metabolite levels in patients with schizophreniaen_US
dc.typearticleen_US
dc.relation.journalANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRYen_US
dc.contributor.department[Dogan, Orhan] Cumhuriyet Univ, Tip Fak, Psikiyatri Anabilim Dali, TR-58140 Sivas, Turkey -- [Ersan, E. Erdal] Numune Hastanesi Psikiyatri Klinigi, Sivas, Turkey -- [Ersan, Serpil] Cumhuriyet Univ, Muhendisl Fak, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.endpage106en_US
dc.identifier.startpage100en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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