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dc.contributor.authorSarac, Bulent
dc.contributor.authorDurmus, Nedim
dc.contributor.authorAltun, Ahmet
dc.contributor.authorTuran, Mustafa
dc.contributor.authorKaya, Tijen
dc.contributor.authorSencan, Mehmet
dc.contributor.authorBagcivan, Ihsan
dc.descriptionWOS: 000298850700008en_US
dc.descriptionPubMed ID: 21921665en_US
dc.description.abstractBackground/Aims: According to recent studies, the endocannabinoid system plays an important role in both physiological and pathophysiological situations. The purpose of the present study was to investigate the effects of cannabinoid (CB) agonists on isolated sheep sphincter of Oddi (SO) in vitro. Methods: The isolated sheep SO tissues were mounted in organ baths and tested for isometric tension and cyclic GMP levels (cGMP) in response to the non-selective CB receptor agonist WIN 55,212-2 and the potent CB1 receptor agonist methanandamide in the presence and absence of the selective CB1 antagonist SR 141716A, the selective CB2 antagonist SR 144528 and the nonspecific inhibitor of nitric oxide (NO) synthase L-NAME. Results: CB agonists relaxed SO in a concentration-dependent manner. These relaxations did not reduce in the presence of SR 144528 but were significantly reduced by SR 141716A and L-NAME. Carbachol significantly increased the cGMP levels compared with the control group and both of the CB receptor agonists significantly increased the cGMP levels compared with the control and carbachol groups. On the other hand, L-NAME prevented the increase in cGMP levels caused by CB agonists. Conclusion: These results show that the relaxation by the agonists may be through CB1 receptors. The decrease of CB relaxation responses by L-NAME, a nonspecific inhibitor of NO synthase, and the increase of cGMP levels in the SO tissues by CB agonists which decreased by L-NAME show that the relaxation effects of these agonists may also partially be via increasing the NO synthesis or release. Copyright (C) 2011 S. Karger AG, Basel and IAPen_US
dc.subjectSphincter of Oddien_US
dc.subjectCannabinoid agonistsen_US
dc.titleEffects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitroen_US
dc.contributor.department[Sarac, Bulent -- Kaya, Tijen -- Bagcivan, Ihsan] Univ Cumhuriyet, Dept Pharmacol, Sivas, Turkey -- [Turan, Mustafa] Univ Cumhuriyet, Dept Gen Surg, Sivas, Turkey -- [Sencan, Mehmet] Univ Cumhuriyet, Dept Hematol, Sivas, Turkey -- [Altun, Ahmet] Univ Cumhuriyet, Fac Med, Sivas, Turkey -- [Durmus, Nedim] Gen Directorate Pharmaceut & Pharm, Minist Hlth Turkey, Dept Pharmacoecon, Ankara, Turkeyen_US
dc.contributor.authorIDAltun, Ahmet -- 0000-0003-2056-8683en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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