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dc.contributor.authorOzen, Filiz
dc.contributor.authorSilan, Coskun
dc.contributor.authorUludag, Ahmet
dc.contributor.authorCandan, Ferhan
dc.contributor.authorSilan, Fatma
dc.contributor.authorOzdemir, Semra
dc.contributor.authorAtik, Sinem
dc.contributor.authorOzdemir, Ozturk
dc.descriptionWOS: 000295339700009en_US
dc.descriptionPubMed ID: 21851199en_US
dc.description.abstractThe multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and drugs. The TT genotype of 3435 codon in exon 26 of MDR1 gene causes overexpression of gene activity and effluxes many chemically diverse compounds across the plasma membrane. We studied the association between C3435T polymorphisms (single nucleotide polymorphism) of MDR1 gene and colchicine-resistant familial Mediterranean fever (FMF) patients. Total genomic DNA samples from 52 FMF patients of colchicine unresponsiveness were used for FMF (MEFV) and MDR1 genes profile analyses. Target genes were genotyped by multiplex PCR-based reverse-hybridization Strip Assay method. The preliminary current results showed increased T allele frequency (0.596) in colchicine unresponsiveness of FMF patients. The distributions of the CC, CT, and TT genotypes in colchicine nonresponder FMF patients were 17%, 46%, and 37%, respectively. Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associated with colchicine resistance in nonresponder FMF patients during the common therapy protocol.en_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subjectC3435T polymorphismen_US
dc.subjectcolchicine resistanceen_US
dc.titleAssociation between ABCB1 (MDR1) Gene 3435 C > T Polymorphism and Colchicine Unresponsiveness of FMF Patientsen_US
dc.relation.journalRENAL FAILUREen_US
dc.contributor.department[Uludag, Ahmet -- Silan, Fatma -- Atik, Sinem -- Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Dept Med Genet, Fac Med, TR-17100 Canakkale, Turkey -- [Ozen, Filiz -- Ozdemir, Ozturk] Cumhuriyet Univ, Dept Med Genet, Fac Med, Sivas, Turkey -- [Silan, Coskun] Canakkale Onsekiz Mart Univ, Dept Pharmacol, Fac Med, TR-17100 Canakkale, Turkey -- [Candan, Ferhan] Cumhuriyet Univ, Dept Internal Med, Fac Med, Sivas, Turkey -- [Ozdemir, Semra] Cumhuriyet Univ, Dept Nucl Med, Fac Med, Sivas, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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