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dc.contributor.authorDogan, Omer Tamer
dc.contributor.authorTurkyilmaz, Suleyman
dc.contributor.authorBerk, Serdar
dc.contributor.authorEpozturk, Kursat
dc.contributor.authorAkkurt, Ibrahim
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:07:20Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:07:20Z
dc.date.issued2010
dc.identifier.issn0300-7995
dc.identifier.issn1473-4877
dc.identifier.urihttps://dx.doi.org/10.1185/03007995.2010.508703
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9791
dc.descriptionWOS: 000282228900021en_US
dc.descriptionPubMed ID: 20690890en_US
dc.description.abstractObjective: Chronic respiratory failure (CRF) is a syndrome defined by certain disturbances in arterial blood gases. Non-invasive mechanical ventilation (NIMV) is an increasingly used treatment modality in respiratory failure. The aim of this study was to investigate the long-term effects of NIMV on pulmonary function and survival of patients with CRF. Methods: The study enrolled 170 CRF patients who it was decided should receive long-term home mechanical ventilation. Patients were stratified into two distinct groups - Group I (patients for whom NIMV was recommended and who had used it) and Group II (patients for whom NIMV was recommended at least 1 year ago but who had not used it for various reasons). Best arterial blood gas and pulmonary function test values in the year before the NIMV recommendation were obtained from patient records. The same tests were performed at least 1 year (1-5 years) after initiation of NIMV therapy in Group I patients and at least 1 year (1-5 years) after prescription of the device in Group II. Results: In the assessments performed 1 year after NIMV recommendation, no difference was found between groups in terms of hospital admissions. However, in Group I, intra-group analysis showed a reduction in the number of hospitalizations 1 year after NIMV. A marked reduction in PaCO2 level was found in Group I patients 1 year after NIMV therapy. Mean survival after NIMV recommendation was 40.27 +/- 3.56 months in Group I, and 27.35 +/- 3.68 months in Group II (log rank = 7.79; p = 0.005). It was found that survival time increased as duration of NIMV usage increased. Conclusion: NIMV therapy has some important and significant benefits in patients with hypercapnic chronic respiratory failure. This study has some limitations in terms of patient selection, power analysis and survival analysis. To assess the effects of NIMV on mortality and pulmonary functions, the authors believe that there is need for prospective, controlled, multicentre studies with longer follow-up periods, improved adherence and novel ventilator modes and settings.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.isversionof10.1185/03007995.2010.508703en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic respiratory failureen_US
dc.subjectHome mechanical ventilationen_US
dc.subjectHypercapniaen_US
dc.subjectNon-invasive mechanical ventilationen_US
dc.titleEffects of long-term non-invasive home mechanical ventilation on chronic respiratory failureen_US
dc.typearticleen_US
dc.relation.journalCURRENT MEDICAL RESEARCH AND OPINIONen_US
dc.contributor.department[Epozturk, Kursat] Cumhuriyet Univ, Fac Med, Dept Chest Dis, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume26en_US
dc.identifier.issue9en_US
dc.identifier.endpage2236en_US
dc.identifier.startpage2229en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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