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dc.contributor.authorYontar, Osman Can
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorYalta, Kenan
dc.contributor.authorTandogan, Izzet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:07:29Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:07:29Z
dc.date.issued2010
dc.identifier.issn1302-8723
dc.identifier.urihttps://dx.doi.org/10.5152/akd.2010.088
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9809
dc.descriptionWOS: 000281309900004en_US
dc.descriptionPubMed ID: 20693125en_US
dc.description.abstractObjective: Leyosimendan is a relatively new inotropic agent. Unlike other inotropic agents, Levosimendan does not increase cellular calcium intake, so that, does not cause intracellular calcium overload and related arrhythmias. Atrial fibrillation (AF) was shown to be an independent risk factor for mortality and morbidity in large heart failure (HF) trials. Heart failure induces AF, AF aggravates HF and therefore they generally coexist. We conducted a study to investigate if there is any differential effect of Levosimendan in HF patients with chronic AF and without AF. Methods: This is a prospective study. Consecutive patients, who were hospitalized because of acutely decompensated HF due to systolic dysfunction and decided Levosimendan administration, were enrolled. Patients were classified into two as those with AF (group A) and those with sinus rhythm (control group, group S). All patients had echocardiography before and after administration. Echocardiographic data were evaluated by ANOVA repeated measurements test. Results: Baseline left ventricle ejection fraction (LVEF) was poorer in group with AF (mean LVEF for group A: 20.9%, for group S: 26.4%, p=0.04). Baseline diastolic parameters were equally impaired. After infusion, diastolic parameters like velocity of propagation (Vp) and isovolumic relaxation time (IVRT) improved almost to same extent in both groups but deceleration time (DT) did not. IVRT values decreased (p=0.012) both in group S (from 108.6 +/- 23.2 msec to 100.4 +/- 28.4 msec) and group A (from 117.3 +/- 25.1 msec to 92.0 +/- 20.9 msec) without a significant difference between groups (p=0.180 for interaction). Another valuable diastolic parameter, Vp was also similarly improved (p<0.01) in both groups to similar extent (for group A, from 35.4 +/- 8.8 cm/sec to 41.1 +/- 7.7 cm/sec, for group S, from 33.7 +/- 7.5 cm/sec to 37.8 +/- 7.6 cm/sec; p=0.498 for interaction). Conclusion: We have shown that in patients with chronic HF and AF, levosimendan improves left ventricular systolic and diastolic functions as good as those with HF and sinus rhythm. We suggest that a positive electrophysiological effect of levosimendan on failing myocardial tissue seems to fill the absence of atrial booster in patients with AF who are on beta-blocker therapy. (Anadolu Kardiyol Berg 2010; 10:310-6) Key words: Heart failure, levosimendan, atrial fibrillationen_US
dc.language.isoengen_US
dc.publisherAVES YAYINCILIKen_US
dc.relation.isversionof10.5152/akd.2010.088en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeart failureen_US
dc.subjectlevosimendanen_US
dc.subjectatrial fibrillationen_US
dc.titleEfficacy of levosimendan in patients with chronic heart failure: Does rhythm matter?en_US
dc.typearticleen_US
dc.relation.journalANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.contributor.department[Yontar, Osman Can -- Yilmaz, Mehmet Birhan -- Yalta, Kenan -- Tandogan, Izzet] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkeyen_US
dc.contributor.authorIDYILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; Yontar, Osman Can -- 0000-0002-0099-8654; YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628en_US
dc.identifier.volume10en_US
dc.identifier.issue4en_US
dc.identifier.endpage316en_US
dc.identifier.startpage310en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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