dc.contributor.author | Sarac, Bulent | |
dc.contributor.author | Durmus, Nedim | |
dc.contributor.author | Bagcivan, Ihsan | |
dc.contributor.author | Altun, Ahmet | |
dc.contributor.author | Turan, Mustafa | |
dc.contributor.author | Sencan, Mehmet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:07:38Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:07:38Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0885-3177 | |
dc.identifier.uri | https://dx.doi.org/10.1097/MPA.0b013e3181d3645b | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9826 | |
dc.description | WOS: 000280190900020 | en_US |
dc.description | PubMed ID: 20697210 | en_US |
dc.description.abstract | Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. Methods: Sheep SO rings were mounted in organ baths and tested for isometric tension and cGMP levels in response to 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene; 3-morpholinosydnonimine hydrochloride (SIN-1); and BAY 41-2272 in the presence and absence of 1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1-one (ODQ). Results: 3,3-bis(Aminoethyl)-1-hydroxy-2-oxo-1-triazene; SIN-1; and BAY 41-2272 relaxed SO rings in a concentration-dependent manner. These relaxations were significantly decreased in the presence of ODQ (P < 0.05). All agents significantly increased the cGMP levels compared with the control group (P < 0.05). The increased cGMP levels in the 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene; and BAY 41-2272-treated groups were significantly different from both control and carbachol groups (P < 0.05), whereas the increase in the SIN-1 group was significantly different from all groups (P < 0.05). The cGMP levels were significantly lower in the presence of ODQ compared with its absence (P < 0.05). Conclusions: The relaxation of SO rings by these agents may be via increasing the levels of cGMP. The additional increase produced by SIN-1 may be the combined effects of NO generation and activation of guanylyl cyclase. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.isversionof | 10.1097/MPA.0b013e3181d3645b | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Sphincter of Oddi | en_US |
dc.subject | NO/cGMP pathway | en_US |
dc.subject | cGMP | en_US |
dc.title | Investigation of Relaxant Effects of New Agents Affecting Nitric Oxide/Cyclic Guanosine Monophosphate Pathway on Sheep Oddi Sphincter | en_US |
dc.type | article | en_US |
dc.relation.journal | PANCREAS | en_US |
dc.contributor.department | [Sarac, Bulent -- Durmus, Nedim -- Bagcivan, Ihsan -- Altun, Ahmet] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Turan, Mustafa] Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Sencan, Mehmet] Cumhuriyet Univ, Sch Med, Dept Internal Med, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Altun, Ahmet -- 0000-0003-2056-8683 | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 878 | en_US |
dc.identifier.startpage | 875 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |