dc.contributor.author | Katrancioglu, N. | |
dc.contributor.author | Manduz, S. | |
dc.contributor.author | Ozen, F. | |
dc.contributor.author | Yilmaz, M. Birhan | |
dc.contributor.author | Karahan, O. | |
dc.contributor.author | Ozdemir, O. | |
dc.contributor.author | Berkan, O. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:13:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:13:40Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0300-0605 | |
dc.identifier.uri | https://dx.doi.org/10.1177/147323001003800435 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9847 | |
dc.description | WOS: 000283025000035 | en_US |
dc.description | PubMed ID: 20926026 | en_US |
dc.description.abstract | Chronic venous insufficiency (CVI) is a common disease associated with poor quality of life. Genetic polymorphisms causing coagulation abnormalities may account for some of the CVI pathogenesis. Type I plasminogen activator inhibitor (PAI-1) is responsible for fibrinolytic system regulation, and plasma levels of PAI-1 are strongly correlated with PAI-1 4G/5G gene polymorphism. The association between PAI-1 4G/5G gene polymorphism and CVI was investigated. In 34 consecutive patients with clinically overt CVI, the PAI-1 4G/4G polymorphism was detected in three cases (8.8%); the 4G/5G polymorphism was detected in 28 (82.4%). In 34 age- and sex-matched controls, the PAI-1 4G/4G polymorphism was detected in one case (2.9%) and the 4G/5G polymorphism was detected in 14 cases (41.2%). The PAI-1 4G allele was found significantly more frequently in CVI patients than in controls. The 4G allele was associated with a 3.25-fold increase in CVI risk. Thus, a relationship between CVI and the PAI-1 4G allele is apparent. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | FIELD HOUSE PUBLISHING LLP | en_US |
dc.relation.isversionof | 10.1177/147323001003800435 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CHRONIC VENOUS INSUFFICIENCY | en_US |
dc.subject | TYPE I PLASMINOGEN ACTIVATOR INHIBITOR | en_US |
dc.subject | GENETIC POLYMORPHISM | en_US |
dc.title | Type I Plasminogen Activator Inhibitor 4G Allele Frequency is Associated with Chronic Venous Insufficiency | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | en_US |
dc.contributor.department | [Katrancioglu, N. -- Manduz, S. -- Karahan, O. -- Berkan, O.] Cumhuriyet Univ, Sch Med, Dept Cardiovasc Surg, TR-58140 Sivas, Turkey -- [Ozen, F. -- Ozdemir, O.] Cumhuriyet Univ, Sch Med, Dept Med Biol & Genet, TR-58140 Sivas, Turkey -- [Yilmaz, M. Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Karahan, Oguz -- 0000-0003-0044-9476; YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628 | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 1518 | en_US |
dc.identifier.startpage | 1513 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |