dc.contributor.author | Gunes, Emine Gulsen | |
dc.contributor.author | Pinarbasi, Ergun | |
dc.contributor.author | Pinarbasi, Hatice | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:13:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:13:40Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1791-2997 | |
dc.identifier.issn | 1791-3004 | |
dc.identifier.uri | https://dx.doi.org/10.3892/mmr_00000321 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9849 | |
dc.description | WOS: 000279207000027 | en_US |
dc.description | PubMed ID: 21472303 | en_US |
dc.description.abstract | The product of AXIN2, a component of Writ signalling, plays a role in tumorigenesis and is dysregulated in cancer cells. In order to determine whether the AXIN2 polymorphism is a risk factor for astrocytoma, we analysed eight polymorphic regions of this gene in 100 astrocytoma patients compared to 100 healthy controls in a Turkish population using PCR-RFLP methods. For the Exon1-148 TIC, Exon 1-432 C/T, Exon5-1365 G/A, Intron5-1712+19G/T, Exon7-2062 C/T and Intron7-2141+73 G/A SNPs of AXIN2, no significant association between controls and astrocytoma patients was found. For the Exon5-1386 C/T SNP, a statistically significant association between controls and patients was found (p<0.05). For this astrocytoma, patients with the TT genotype showed an increased risk with an OR of 2.92 (adjusted for age, gender and smoking status) (95% CI 1.14-7.47) as compared to the controls with the CC genotype. Our results suggest that AXIN2 SNPs may be associated with astrocytoma. | en_US |
dc.description.sponsorship | Cumhuriyet University CUBAP (Sivas, Turkey) [T-299] | en_US |
dc.description.sponsorship | This study was supported by Grant no. T-299 from Cumhuriyet University CUBAP (Sivas, Turkey). The technical assistance of Ms. Meral Yilmaz is gratefully acknowledged. We also thank Dr Mustafa Gurelik. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.relation.isversionof | 10.3892/mmr_00000321 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | AXIN2 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | astrocytoma | en_US |
dc.subject | Turkish population | en_US |
dc.title | AXIN2 polymorphism and its association with astrocytoma in a Turkish population | en_US |
dc.type | article | en_US |
dc.relation.journal | MOLECULAR MEDICINE REPORTS | en_US |
dc.contributor.department | [Gunes, Emine Gulsen -- Pinarbasi, Ergun] Cumhuriyet Univ, Fac Med, Dept Med Biol, TR-58140 Sivas, Turkey -- [Pinarbasi, Hatice] Cumhuriyet Univ, Fac Med, Dept Med Biochem, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 709 | en_US |
dc.identifier.startpage | 705 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |