dc.contributor.author | Pinarbasi, Hatice | |
dc.contributor.author | Silig, Yavuz | |
dc.contributor.author | Pinarbasi, Ergun | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:13:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:13:40Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1791-2997 | |
dc.identifier.uri | https://dx.doi.org/10.3892/mmr_00000324 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9850 | |
dc.description | WOS: 000279207000030 | en_US |
dc.description | PubMed ID: 21472306 | en_US |
dc.description.abstract | Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively. The exon 3 polymorphism reduces enzyme activity by approximately 50%, whereas the exon 4 polymorphism causes a 25% increase in activity. In the present study, the distribution of these polymorphisms in a Turkish population including 625 unrelated healthy individuals was examined using a PCR-RFLP method. The observed genotype frequencies of microsomal epoxide hydrolase exon 3 were 54,38 and 8% for Tyr113Tyr, Tyr113His and His113His, respectively. Exon 4 genotype frequencies were found to be 69, 29 and 2% for His139His, His139Arg and Arg139Arg, respectively. | en_US |
dc.description.sponsorship | Cumhuriyet University CU BAP, Sivas, Turkey [T-277] | en_US |
dc.description.sponsorship | This work was supported by grant no. T-277 from the Cumhuriyet University CU BAP, Sivas, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.relation.isversionof | 10.3892/mmr_00000324 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | microsomal epoxide hydrolase | en_US |
dc.subject | polymorphism | en_US |
dc.title | Microsomal epoxide hydrolase polymorphisms | en_US |
dc.type | article | en_US |
dc.relation.journal | MOLECULAR MEDICINE REPORTS | en_US |
dc.contributor.department | [Pinarbasi, Hatice -- Silig, Yavuz] Cumhuriyet Univ, Dept Biochem, Fac Med, TR-58140 Sivas, Turkey -- [Pinarbasi, Ergun] Cumhuriyet Univ, Dept Med Biol, Fac Med, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 727 | en_US |
dc.identifier.startpage | 723 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |