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dc.contributor.authorGulturk, Sefa
dc.contributor.authorDemirkazik, Ayse
dc.contributor.authorKosar, Ilkay
dc.contributor.authorCetin, Ali
dc.contributor.authorDokmetas, Hatice S.
dc.contributor.authorDemir, Tuncer
dc.descriptionWOS: 000276858700002en_US
dc.descriptionPubMed ID: 19953571en_US
dc.description.abstractWe investigated the effect of long-term exposure to modulation magnetic field (MF), insulin, and their combination on blood brain barrier (BBB) permeability in a diabetic rat model. Fifty-three rats were randomly assigned to one of six groups: sham, exposed to no MF; MF, exposed to MF; diabetes mellitus (DM), DM induced with streptozotocin (STZ); DM plus MF (DMMF); DM plus insulin therapy (DMI); and DM plus insulin therapy plus MF (DMIMF). All the rats underwent Evans blue (EB) measurement to evaluate the BBB 30 days after the beginning of experiments. The rats in MF, DMMF, and DMIMF groups were exposed to MF (B = 5 mT) for 165 min every day for 30 days. Mean arterial blood pressure (MABP), body mass, and serum glucose level of the study rats were recorded. The extravasation of brain EB of the MF, DM, DMMF, DMI, and DMIMF groups was higher than that of the sham group and the extravasation of right hemisphere of the DMIMF group was highest (P < 0.05). The post-procedure body mass of the sham and MF groups were significantly higher than those of the DM and DMMF groups (P < 0.05). In the DM, DMMF, DMI, and DMIMF groups, the baseline glucose was significantly lower than the post-procedure glucose (P < 0.05). DM and MF increase BBB permeability; in combination, they cause more increase in BBB permeability, and insulin decreases their effect on BBB. Improved glucose metabolism may prevent body mass loss and the hypoglycemic effect of MF. DM increases MABP but MF causes no additional effect. Bioelectromagnetics 31:262-269, 2010. (C) 2009 Wiley-Liss, Inc.en_US
dc.subjectblood-brain barrieren_US
dc.subjectstreptozotocin-induced diabetesen_US
dc.subjectelectromagnetic fielden_US
dc.titleEffect of Exposure to 50 Hz Magnetic Field With or Without Insulin on Blood Brain Barrier Permeability in Streptozotocin-Induced Diabetic Ratsen_US
dc.contributor.department[Gulturk, Sefa -- Demir, Tuncer] Cumhuriyet Univ, Sch Med, Dept Physiol, TR-58140 Sivas, Turkey -- [Demirkazik, Ayse] Cumhuriyet Univ, Sch Med, Dept Biophys, TR-58140 Sivas, Turkey -- [Kosar, Ilkay] Cumhuriyet Univ, Sch Med, Dept Anat, TR-58140 Sivas, Turkey -- [Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Dokmetas, Hatice S.] Cumhuriyet Univ, Sch Med, Dept Internal Med, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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