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dc.contributor.authorBilge Onarlıoğlu
dc.contributor.authorYasemin Günay
dc.contributor.authorİsmihan Göze
dc.contributor.authorEmel Koptagel
dc.date.accessioned23.07.201910:49:13
dc.date.accessioned2019-07-23T16:19:43Z
dc.date.available23.07.201910:49:13
dc.date.available2019-07-23T16:19:43Z
dc.date.issued1998
dc.identifier.issn1300-0144
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TmpJNU5UVT0=
dc.identifier.urihttps://hdl.handle.net/20.500.12418/998
dc.description.abstractDiethylstilbestrol (DES), nons-teroid in structure, is an artificial estrogen derivative and is used as an anabolic agent. It is known that diethylstilbestrol causes genet-ic disorders and toxic effects leading up to carcinoma even in amounts below its residual levels. For this purpose, a dose of 60um/kg/day of DES dissolved in 0,1 ml corn oil has been administered to rats by oral gavage for vary-ing periods of 20, 50 and 100 days periods. Rat renal tissue samples, following routine electron microscopical procedure, have been examined by transmission electron microscopy. Following diethylstilbestrol administration,glomerular capilleries seemed dilated along with occasional basement membrane thicken-ings and degenerations in slit membrane. In addition, irregular endothelial cell fenestrae were observed. Distal tubular structure remained intact but in the proximal tubuli, cells with picnotic nuclei and dilated intracy-toplasmic foldings were present. These histological alterations increased parallel to the duration of the dosage period. These findings suggest that the diethylstilbe-strol usage may cause irreversible structural changes in rat renal tissue.en_US
dc.description.abstractDiethylstilbestrol (DES), nons-teroid in structure, is an artificial estrogen derivative and is used as an anabolic agent. It is known that diethylstilbestrol causes genet-ic disorders and toxic effects leading up to carcinoma even in amounts below its residual levels. For this purpose, a dose of 60um/kg/day of DES dissolved in 0,1 ml corn oil has been administered to rats by oral gavage for vary-ing periods of 20, 50 and 100 days periods. Rat renal tissue samples, following routine electron microscopical procedure, have been examined by transmission electron microscopy. Following diethylstilbestrol administration,glomerular capilleries seemed dilated along with occasional basement membrane thicken-ings and degenerations in slit membrane. In addition, irregular endothelial cell fenestrae were observed. Distal tubular structure remained intact but in the proximal tubuli, cells with picnotic nuclei and dilated intracy-toplasmic foldings were present. These histological alterations increased parallel to the duration of the dosage period. These findings suggest that the diethylstilbe-strol usage may cause irreversible structural changes in rat renal tissue.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleRenal ultrastructural Alterations following administration of diethyistilbestrolen_US
dc.typeotheren_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.contributor.departmentSivas Cumhuriyet Üniversitesien_US
dc.identifier.volume28en_US
dc.identifier.issue4en_US
dc.identifier.endpage374en_US
dc.identifier.startpage369en_US
dc.relation.publicationcategoryDiğeren_US]


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