Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis
dc.contributor.author | Bulun, Serdar E. | |
dc.contributor.author | Cheng, You-Hong | |
dc.contributor.author | Pavone, Mary Ellen | |
dc.contributor.author | Xue, Qing | |
dc.contributor.author | Attar, Erkut | |
dc.contributor.author | Trukhacheva, Elena | |
dc.contributor.author | Tokunaga, Hideki | |
dc.contributor.author | Utsunomiya, Hiroki | |
dc.contributor.author | Yin, Ping | |
dc.contributor.author | Luo, Xia | |
dc.contributor.author | Lin, Zhihong | |
dc.contributor.author | Imir, Gonca | |
dc.contributor.author | Thung, Stephen | |
dc.contributor.author | Su, Emily J. | |
dc.contributor.author | Kim, J. Julie | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:13:55Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:13:55Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1526-8004 | |
dc.identifier.uri | https://dx.doi.org/10.1055/s-0029-1242991 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9993 | |
dc.description | WOS: 000273921100006 | en_US |
dc.description | PubMed ID: 20104427 | en_US |
dc.description.abstract | Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine signaling. PR deficiency likely underlies the development of progesterone resistance in women with endometriosis who no longer respond to progestin therapy. Here we review the complex epigenetic and transcriptional mechanisms leading to PR deficiency. The initial event may involve deficient methylation of the estrogen receptor (ER)beta promoter resulting in pathologic overexpression of ER beta in endometriotic stromal cells. We speculate that alterations in the relative levels of ER beta and ER alpha in endometrial tissue dictate E2-regulated PR expression, such that a decreased ER alpha-ER beta ratio may result in suppression of PR. In this review, we propose a molecular model that may be responsible for changes in ER beta and ER alpha leading to PR loss and progesterone resistance in endometriosis. | en_US |
dc.description.sponsorship | NICHD [HD040093]; Friends of Prentice | en_US |
dc.description.sponsorship | This article was supported by grants from the NICHD (HD040093) and Friends of Prentice ( both to S. E. B.). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | THIEME MEDICAL PUBL INC | en_US |
dc.relation.isversionof | 10.1055/s-0029-1242991 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ER-beta | en_US |
dc.subject | ER-alpha | en_US |
dc.subject | PR | en_US |
dc.subject | progesterone resistance | en_US |
dc.subject | DNA methylation | en_US |
dc.subject | epigenetic | en_US |
dc.subject | promoter | en_US |
dc.subject | gene regulation | en_US |
dc.subject | transcription | en_US |
dc.title | Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis | en_US |
dc.type | article | en_US |
dc.relation.journal | SEMINARS IN REPRODUCTIVE MEDICINE | en_US |
dc.contributor.department | [Bulun, Serdar E. -- Cheng, You-Hong -- Pavone, Mary Ellen -- Trukhacheva, Elena -- Yin, Ping -- Luo, Xia -- Lin, Zhihong -- Su, Emily J. -- Kim, J. Julie] Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Div Reprod Biol Res, Chicago, IL 60611 USA -- [Xue, Qing] Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China -- [Attar, Erkut] Istanbul Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Capa Sch Med, Istanbul, Turkey -- [Tokunaga, Hideki -- Utsunomiya, Hiroki] Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan -- [Imir, Gonca] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey -- [Thung, Stephen] Yale Univ, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, New Haven, CT 06510 USA | en_US |
dc.contributor.authorID | Pavone, Mary Ellen -- 0000-0001-9682-6381 | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 43 | en_US |
dc.identifier.startpage | 36 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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