dc.contributor.author | Kaptanoglu, Ece | |
dc.contributor.author | Nadir, Isilay | |
dc.contributor.author | Bakici, Zahir | |
dc.contributor.author | Hayta, Emrullah | |
dc.contributor.author | Turkmen, Mehmet | |
dc.contributor.author | Sezer, Hafize | |
dc.contributor.author | Hizmetli, Sami | |
dc.contributor.author | Elden, Hasan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:13:56Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:13:56Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1309-0291 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9999 | |
dc.description | WOS: 000276859300003 | en_US |
dc.description.abstract | Objective: Differentiation of rheumatoid arthritis (RA) from other diseases with joint involvement such as hepatitis-C virus (HCV) infection represents a diagnostic problem. In addition to the rheumatoid factor (RF), more specific and sensitive auto-antibodies are under evaluation in recent years with conflicting results. In this study, we tested the diagnostic value of rheumatoid factor, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) in distinguishing RA from hepatitis C patients. Materials and Methods: Sera of 34 RA patients and 30 hepatitis C patients were tested for RF, anti-CCP anti-MCV. Disease activity was determined by disease activity score (DAS-28) 28 in RA and by modified Knodell score in hepatitis C patients. Extra-articular involvement in RA and rheumatologic involvement in hepatitis C patients were documented. Results: In roc analysis, area under curve (AUC) was the highest in anti-CCP. Sensitivity and specificity was 82% and 53%, 79%, and 96% and 70%, and 73% for RF, anti-CCP and anti-MCV respectively. DAS-28 has a weak correlation with RF (r=0.406), anti-CCP (r=0.433), and anti-MCV (r=0.453). There was no difference between the patients in autoantibody levels regarding extra-articular involvement and DAS-28 in RA, and joint involvement in hepatitis C patients. Conclusion: Anti-MCV antibodies may be useful in distinguishing RA however it seems to have no additional value over anti-CCP or RF in hepatitis C patients. Anti-CCP antibodies are more reliable in diagnosis of RA due to their high specificity. (Turk J Rheumatol 2010; 25: 19-23) | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AVES YAYINCILIK, IBRAHIM KARA | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | HCV | en_US |
dc.subject | rheumatoid factor | en_US |
dc.subject | anti-CCP | en_US |
dc.subject | anti-MCV | en_US |
dc.title | Differentiation of Rheumatoid Arthritis From HCV Infection: Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide or Anti-Mutated Citrullinated Vimentin? | en_US |
dc.type | article | en_US |
dc.relation.journal | TURKISH JOURNAL OF RHEUMATOLOGY-TURK ROMATOLOJI DERGISI | en_US |
dc.contributor.department | [Kaptanoglu, Ece -- Turkmen, Mehmet -- Hizmetli, Sami -- Elden, Hasan] Cumhuriyet Univ, Tip Fak, Fiziksel Tip & Rehabil Anabilim Dali, Sivas, Turkey -- [Nadir, Isilay] Numune Devlet Hastanesi, Gastroenterol Bolumu, Sivas, Turkey -- [Bakici, Zahir] Cumuriyet Univ, Tip Fak, Mikrobiyol Anabilim Dali, Sivas, Turkey -- [Hayta, Emrullah] Numune Devlet Hastanesi, Fiz Tedavi Bolumu, Sivas, Turkey -- [Sezer, Hafize] Cumhuriyet Univ, Tip Fak, Biyoistat Bolumu, Sivas, Turkey | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 23 | en_US |
dc.identifier.startpage | 19 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |