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Öğe Degenerated leiomyoma of the round ligament: A case report(2006) Imir, Ayşe Gonca; Piçak, Alparslan; Arici, Sema; Kilçik, Mehmet Ali; Çetin, MeralTumors of the round ligament are very uncommon and leiomyoma is the most frequent one among these tumors. Most of leiomyomas of the round ligament are asymptomatic. In this report, we present the diagnosis, treatment, and clinical outcome of a myoma originating from the abdominal portion of the round ligament, a A 38-year-old female presented with a complaint of intermittent right groin pain has been diagnosed as degenerated leiomyoma of the round ligament after sonographic and pathological examination. Round ligament myomas are reported only 16 cases in the literature. The pathologic evaluation after surgical management is mandatory for the diagnosis of round ligament myomas.Öğe Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death(2023) Ünal, Gamze Sönmez; Albak, Yasemin; Yurtcu, Nazan; Yıldız, Çağlar; Çetin, Meral; Daştan, Sevgi Durna; Gümüş, ErkanObjective: This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model. Materials and Methods: Five groups were formed with eight animals in each group. One of the groups was set as the control group. Endometriotic lesions were created by transplanting 40 mouse autologous endomyometrial tissues into the mouse subcutaneous tissue to a highly vascular surface. Gene expression analyzes of tissues were performed as HIF-1a, ATG5, ATG12, Beclin2, Beclin1, LC3BII, CateninB, GSK3b, TCF, WNT2, WNT7a, and WNT10a gene analyzes. Drug effects were examined by histological examination. HIF1a and WNT2 protein expressions were examined immunohistochemically. Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables. Data are presented as mean and standard error. Results: Beclin2 gene expression coefficients of metformin 1st day, metformin 7th day, ganirelix 1st day, and general 7th day groups were found to have significantly decreased compared with the control group coefficient. Beclin1 gene expression coefficients of metformin 1st day, metformin 7th day, ganirelix 1st day, and genirelix 7th day groups were found to have significantly decreased compared with the control group coefficient. LC3BII gene expression coefficients of metformin 1st day and metformin 7th day groups were found to have significantly decreased compared withLC3BII gene expression coefficients of control, genirelix 1st day, and genirelix 7th day groups. These findings were supported by histological and immunohistochemical staining. Conclusion: These genes are actively involved in the autophagy pathway, and we think that the use of metformin in endometriosis might create an autophagy-based suppression mechanism.Öğe Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death/Otofaji ile iliskili hucrelerde subkutan endometriozis fare modelinde metformin ve genireliksin etkisi.(Galenos Yayinevi Tic. Ltd., Eylül/2023) YURTCU, Nazan; Sönmez Ünal, Gamze; Albak, Yasemin; Yıldız, Çağlar; Çetin, Meral; DURNA DAŞTAN, SEVGİObjective This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model. Materials and Methods Five groups were formed with eight animals in each group. One of the groups was set as the control group. Endometriotic lesions were created by transplanting 40 mouse autologous endomyometrial tissues into the mouse subcutaneous tissue to a highly vascular surface. Gene expression analyzes of tissues were performed as HIF-1a, ATG5, ATG12, Beclin2, Beclin1, LC3BII, CateninB, GSK3b, TCF, WNT2, WNT7a, and WNT10a gene analyzes. Drug effects were examined by histological examination. HIF1a and WNT2 protein expressions were examined immunohistochemically. Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables. Data are presented as mean and standard error. Results Beclin2 gene expression coefficients of metformin 1st day, metformin 7th day, ganirelix 1st day, and general 7th day groups were found to have significantly decreased compared with the control group coefficient. Beclin1 gene expression coefficients of metformin 1st day, metformin 7th day, ganirelix 1st day, and genirelix 7th day groups were found to have significantly decreased compared with the control group coefficient. LC3BII gene expression coefficients of metformin 1st day and metformin 7th day groups were found to have significantly decreased compared with LC3BII gene expression coefficients of control, genirelix 1st day, and genirelix 7th day groupsÖğe The diagnostic value of preoperative neutrophil-to-lymphocyte ratio in patients with endometrial, cervical and ovarian cancers(Gunes Kitap Kirtasiye, 2015) Yıldız, Çağlar; Akkar, Özlem Bozoklu; Karakuş, Savaş; Yeniocak, Hidayet; Çetin, Meral; Çetin, Ali; Yanık, AliObjective: The aim of this study was to evaluate the usage of preoperative neutrophil-to-lymphocyte ratio and mean platelet volume as biomarkers for the prediction of cancer stage in patients with endometrial, ovarian, and cervical cancer. Materials and Methods: In the study, the file data of patients diagnosed with endometrial, ovarian and cervical cancer between 2008 and 2014 in Obstetrics and Gynecology department of Cumhuriyet University Faculty of Medicine were used. Sixty-nine cases with endometrial adenocancer, 48 cases with epithelial ovarian cancer, and 23 cases with squamous cell cervical cancer were included. Demographic and laboratory data were evaluated. Neutrophil-to-lymphocyte ratio was calculated as the absolute neutrophil count divided by the absolute lymphocyte count. Results: In patients with advanced endometrial and ovarian carcinoma, neutrophil-to-lymphocyte ratios were found higher than those with early stages of such (p<0.05). Neutrophil-to-lymphocyte ratios of the cervical cancer patients with early-and advancedstage tumor were not significantly different (p>0.05). The mean platelet volume values of patients with early-and advanced-stage tumors were found similar (p>0.05). Conclusion: There is an association between advanced stage of tumor and neutrophil-to-lymphocyte ratio in cases with endometrial and ovarian cancers. However, no relationship was found between the mean platelet volume and tumoral stage in gynecological cancers. Neutrophil-to-lymphocyte ratio may be used in diagnostic work-up of endometrial and ovarian cancers to assess the advanced tumoral stage. © 2015, Gunes Kitap Kirtasiye. All rights reserved.Öğe Validation of Turkish version of Premenstrual Symptoms Impact Survey (PMSIS ) for assessing status of premenstrual syndrome in women of reproductive age(2015) Güler, Ömer Tolga; Ataçağ, Tijen; Yaycı, Eyüp; Çetin, Ali; Çetin, MeralAmaç: Adet Öncesi Ş ikayetler Etki Ölçeği (Premenstrual Symptoms Impact Survey [PMSIS ]) Türkçe sürümünün geçerlilik ve güvenilirliğinin araştırılması amaçlandı. Bu ölçek, altı soru ile premenstrüel sendromun (PMS),bireyin işlevsel sağlık ve iyilik durumu üzerine etkisini ölçümleyebilmektedir. Yöntem: İngilizce olan PMSIS ninTürkçeye bağımsız olarak çevrildikten sonra geri çeviri yöntemi ile adaptasyonu yapıldı. Yıllık sağlıklı kadın jinekolojik muayenesi ile sağlıklı bulunan ve üreme döneminde olan 63 kadın üzerinden ölçeğin geçerliliği ve güvenilirliğiincelendi. Türkçe bir ölçek olan Premenstrüel Sendrom Ölçeği (PMSÖ), PMSIS in eş zamanlı geçerliliğini belirle-mek için kullanıldı. Ölçek verilerinin analizinde içerik geçerliliği, test-tekrar test güvenilirliği, Cronbach alfa, eşzamanlı geçerlilik ve yapı geçerliliği testleri uygulandı. Bulgular: Ölçeğin içerik geçerliliği yüksek (%91) bulundu.Güvenilirlik analizleri sonucunda, PMSIS in birinci ve ikinci uygulamalarının puanları arasında sınıf-içi korelasyondeğeri 0.70 bulundu ve ölçeğin test ve tekrar-test sonuçları iyi uyumlu olarak yorumlandı; ayrıca Cronbach alfadeğeri 0.89 bulundu ve iç tutarlılığı yeterli ve yüksek olarak yorumlandı. Eş zamanlı geçerlilik analizleri sonucunda,PMSIS in birinci uygulaması ve PMSÖ uygulaması puanlarının Pearson korelasyon katsayısı 0.70 bulundu. Yapıgeçerliliği analizi için yapılan faktör analizi, özgün ölçekte olduğu gibi tüm maddelerin tek boyutta toplandığını, faktöryüklerinin 0.74-0.84 arasında değiştiğini ve toplam varyansın %65.1 olduğunu gösterdi. PMSIS ölçeğinin eşzamanlı ve yapısal geçerlilikleri iyi olarak yorumlandı. Sonuçlar: PMSIS in Türkçe sürümü, iyi geçerlilik ve güveni-lirlik özelliklerine sahiptir. Ölçek güvenilir, tutarlı ve geçerli bir ölçek olarak üreme dönemindeki kadınlarda PMSdurumunu ve PMS tedavisinin sonuçlarını Türk toplumunda değerlendirebilir.
