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    Histopathological and Biochemical Investigation of the Effect of Shilajit on Liver and Kidney in Rats with Experimental Spinal Cord Injury
    (2023) Sancak, Tunahan; Okulmuş, Çağlar; Akyol, Mehmet Edip; Keleş, Ömer Faruk; Çetin, Eyüp
    Objective: In this study, it was aimed to determine the effect of shilajit on the liver and kidney in rats with experimental spinal cord injury. Materials and Methods: Spinal cord injury-induced rats were treated with shilajit at doses of 150 mg/kg and 250 mg/kg on days 1, 2, and 3. Following the administration, rats were sacrificed on the 14th day, and blood, liver, and kidney tissues were collected. Results: The histopathological analysis of the liver and kidney revealed that high doses of shilajit showed a greater protective effect in the tissues and low doses showed only a partial protective effect. In biochemical analysis, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine, and urea concentrations were lower and albumin (ALB) and total protein (TP) concentrations were higher in shilajit-treated groups compared with the control group (P range: 0.05–0.001). Conclusion: As a result, in this study, it has been histopathologically and biochemically revealed that administration of the Shilajit significantly suppressed the formation of the lesions in liver and kidney with its anti-inflammatory properties after spinal cord injury in rats.
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    Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury
    (Turkish Assoc Trauma Emergency Surgery, 2023) Cetin, Eyup; Sancak, Tunahan; Keles, Omer Faruk; Unlu, Ilker; Akyol, Mehmet Edip; Arabaci, Ozkan
    BACKGROUND: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI). METHODS: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. High-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 250 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. Thin sections taken from the spinal cord after euthanasia were sent for histopathological and immunohistochemical examination. RESULTS: Histopathological examination of the high-dose group showed lower amounts of morphological findings compared to the low-dose group and control group. While a significant CD68 immune reaction was observed in the control group of rats with spinal injury, the positive immune reaction was found to be significantly decreased in the Shilajit-applied groups. CONCLUSION: It is thought that the use of Shilajit in SCI will reduce the effects of secondary damage in SCI and that its administration to such patients will have positive effects on the results.