Histopathological and Biochemical Investigation of the Effect of Shilajit on Liver and Kidney in Rats with Experimental Spinal Cord Injury

Objective: In this study, it was aimed to determine the effect of shilajit on the liver and kidney in rats with experimental spinal cord injury. Materials and Methods: Spinal cord injury-induced rats were treated with shilajit at doses of 150 mg/kg and 250 mg/kg on days 1, 2, and 3. Following the administration, rats were sacrificed on the 14th day, and blood, liver, and kidney tissues were collected. Results: The histopathological analysis of the liver and kidney revealed that high doses of shilajit showed a greater protective effect in the tissues and low doses showed only a partial protective effect. In biochemical analysis, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine, and urea concentrations were lower and albumin (ALB) and total protein (TP) concentrations were higher in shilajit-treated groups compared with the control group (P range: 0.05–0.001). Conclusion: As a result, in this study, it has been histopathologically and biochemically revealed that administration of the Shilajit significantly suppressed the formation of the lesions in liver and kidney with its anti-inflammatory properties after spinal cord injury in rats.