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Öğe A 53-year-old female with bladder leiomyoma: A rare case and review of the literature(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Asdemir, Tugba Yildiz; Saygin, Huseyin; Korgali, Esat; Cicek, ResulLeiomyoma as a benign tumor of the urinary bladder, is uncommon and usually presents with obstructive voiding symptoms or irritative urinary symptoms. A 53-year-old woman was hospitalized to the general surgery clinic due to abdominal pain. During her contrast-enhanced computed tomography (CT) examination, incidentally, a mass on the left anterosuperolateral side of the bladder wall was revealed. No significant finding was detected on physical examination. There was only microscopic hematuria as a result of urinalysis. Contrast-enhanced CT confirmed the presence of a mass on the left anterosuperolateral side of the bladder wall without evidence of extravesical extension and showed a well-delineated 2,6 cm x 2,4 cm endovesical bladder tumor arising from the left anterosuperolateral bladder wall and there was a thickening of the urinary bladder wall. On cystoscopy, an intraluminally protruding, rounded, smooth, sessile solid mass, 2,5 cm in diameter and covered by normal bladder mucosa, was seen. She underwent an uneventful transurethral resection of bladder tumor (TURBT) and histological examination revealed intersecting fascicles of smooth muscle without any evidence of malignant change, and thus diagnosis of leiomyoma was confirmed. Confirmation of the diagnosis may be difficult due to the poor yield of cold cup biopsy. In our case, transurethral resection (TUR) was diagnostic.Öğe Analgesic efficacy of using topical anesthetic before dorsal penile nerve block in infant circumcision: A randomized-controlled study(Logos Medical Publishing, 2024) Ergin, İsmail Emre; Öztürk, Abuzer; Asdemir, Aydemir; Saygin, HüseyinObjectives: The aim of this study was to investigate the effect of lidocaine-prilocaine cream (LPC) application on circumcision analgesia and algology before dorsal penile nerve block (DPNB). Patients and methods: Between January 2024 and April 2024, a total of 128 healthy male infants aged 1 to 12 months, who were screened and underwent circumcision under local anesthesia in our clinic, were included in this randomized-controlled study. The patients were divided into two groups as the DPNB group (DPNB group, n=64) and the DPNB+LPC group (n=64). The heart rate (HR), respiratory rate (RR), peripheral arterial oxygen saturation (SpO2) changes, and Neonatal Infant Pain Scale (NIPS) scores were measured during the surgical stages of the groups with and without topical analgesia before DPNB. The values at the time of DPNB injection, at the time of circumcision, and at 3 min after the end of the operation were recorded. Results: There was no statistically significant difference in the mean age and body weight of the patients between the groups (p>0.05). There was also no statistically significant difference between the HR, RR, and SpO2 of the groups before the operation (baseline), at the time of local analgesic needle insertion, during circumcision and after the operation (p>0.05). The NIPS scores at the time of local anesthetic needle insertion were significantly different (p=0.04), although there was no significant difference in the NIPS scores at the other time points (p>0.05). Conclusion: Our study results suggest that LPC application before DPNB yields favorable effects in terms of local anesthesia and ease of surgery, and it is a safe technique to apply. © 2024 Logos Medical Publishing. All rights reserved.Öğe Clinical characteristics and results of 45 patients who had adrenalectomy in our clinic(Bayrakol Medical Publisher, 2024) Asdemir, Aydemir; Ergin, Ismail Emre; Ozturk, Abuzer; Saygin, Hueseyin; Korgali, EsatAim: Laparoscopic adrenalectomy is a widely preferred method today. In recent years, many studies have reported that laparoscopic adrenalectomy requires less analgesic, less bleeding, lower complication rates and less hospitalization compared to open surgery. This study aimed to compare the surrenalectomy data performed in our clinic. Material and Methods: The data of surrenalectomies performed in our urology clinic between December 2010 and March 2022 were compared. Age, sex, side information, surgical method, and pathology results were recorded. Results: Forty five patients, aged between 26 and 83, were retrospectively analyzed. Of 45 patients who underwent surrenalectomy, 1 (2.2%) was bilateral, 25 (55.5%) were right, and 19 (42.3%) were left (42.3%) adrenalectomy. Of these cases, 18 (39.6%) were male, 27 (59.4%) were female, 31 (on one side of the bilateral) (67.4%) laparoscopic operation and 15 (on the other side of the bilateral) (32.6%) of them were open operation. Postoperative histopathological results were 17 (36.95%) adrenal cortical adenomas, 8 (17.4%) benign pheochromocytomas, 2 (4.35%) malignant pheochromocytomas, 6 (13.04%) adrenal cysts, 5 (10.86%) carcinoma metastases, 2 (4.36%) myelolipomas, 2 (4.36%) benign adrenal cortical oncocytomas, 1 (2.17%) borderline adrenal cortical oncocytoma, 1 (2.17%) oncocytic adrenal cortical carcinoma, 1 (2.17%) hydatid cyst and 1 (2.17%) adrenal tissue containing areas of bleeding and necrosis. Discussion: Histopathological results of surrenalectomy are not only significant in terms of malignancy but also important in terms of the treatment plan.Öğe Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway(Humana Press Inc, 2024) Asdemir, Aydemir; Ozgur, AykutProstate cancer is one of the most common cancers in men. Given the diverse nature of prostate cancer and its tendency to respond differently to various treatments, combination therapies are often employed to enhance outcomes. In this study, the synergetic efficiency of chemotherapeutic drug Navitoclax and heat shock protein 90 (Hsp90) inhibitor Debio-0932 was evaluated in human prostate cancer cell line (PC3). Our results indicated that Navitoclax-Debio-0932 combination exhibited synergistic activity in PC3 cells at concentrations lower than IC50 values. The combination of Navitoclax and Debio-0932 decreased PC3 cell viability in a dose dependent manner at 48 h. To investigate the apoptotic potential of the Navitoclax-Debio-0932 combination against prostate cancer cells, the mRNA and protein expression levels of apoptotic and antiapoptotic markers (Bax, Bcl-2, Bcl-xL, Cyt-c, Apaf-1, Casp-3, Casp-7, and Casp-9) were measured using RT-PCR and ELISA assay. Furthermore, the cleavage activity of Casp-3 was determined by colorimetric assay. The results revealed that Navitoclax-Debio-0932 combination potently induced intrinsic apoptotic pathway in PC3 cells rather than using drugs alone. The combined treatment of Navitoclax and Debio-0932 displayed synergistic cytotoxic and apoptotic effects on prostate cancer cells, presenting a promising approach for combination therapy in prostate cancer.Öğe Comparison of Prostate Specific Antigen and Neuropeptide Y Parameters in Patients with Prostate Cancer(Galenos Publ House, 2024) Ozturk, Abuzer; Saygin, Huseyin; Asdemir, Aydemir; Bolat, Serkan; Ergin, Ismail Emre; Kirac, Emre; Korgali, EsatObjective: Prostate cancer is a solid tumor that can be fatal in men. Early detection and proper management are essential for improving outcomes and reducing mortality rates associated with this disease. This study aimed to evaluate the potential of neuropeptide Y (NPY) as a biomarker to enhance the effectiveness of prostate specific antigen (PSA) testing in diagnosing and predicting prostate cancer prognosis. NPY, a well-known sympathetic neurotransmitter, possesses growth-promoting and angiogenic properties in various cell types, including those relevant to prostate cancer. Additionally, NPY has been linked to neuroendocrine differentiation of prostate cancer cells. By comparing the efficacy of PSA testing alone with the addition of NPY, this study aimed to determine whether NPY could offer additional predictive value for prostate cancer progression and prognosis. Materials and Methods: This study involved 90 patients each diagnosed with localized prostate cancer (LPC), metastatic prostate cancer (mPC) at diagnosis, and metastatic castration-resistant prostate cancer (mCRPC) who visited our urology clinic between 2022 and 2023. Blood samples were collected from all participants between 08:00 and 09:00 after a 12 hour fast. In the LPC and mPC groups, samples were collected upon diagnosis, whereas in the mCRPC group, samples were collected upon development of treatment resistance. NPY levels in blood samples were analyzed using enzyme-linked immunosorbent assay method. Serum NPY levels were compared between the LPC, mPC, and mCRPC groups. Results: PSA values were calculated as 12.6 (7.08-32.47) ng/L in the LPC group, 159 (73.1-405.2) ng/L in the mPC group, and 38.33 (18.4-132) ng/L in the mCRPC group, with a statistically significant difference between the groups (p<0.001). The average NPY values were 351.3 +/- 162.7 ng/L in the LPC group, 276.5 +/- 85 ng/L in the mPC group, and 272.13 +/- 94.7 ng/L in the mCRPC group. NPY values were found to be statistically significantly higher in the LPC group (p=0.018). Conclusion: The serum NPY levels were notably elevated in the LPC group compared with the mPC and mCRPC groups. This finding implies a potential association between low NPY levels and mPC as well as mCRPC.Öğe Correlation Between PSA Density and Multiparametric Prostate MRI in the Diagnosis of Prostate Cancer(Galenos Publ House, 2024) Aslanoglu, Ahmet; Saygin, Huseyin; Ozturk, Abuzer; Ergin, Ismail Emre; Asdemir, Aydemir; Velibeyoglu, Arslan Fatih; Korgali, EsatObjective: In the diagnosis of prostate cancer, only digital rectal examination and prostate -specific antigen (PSA) testing cause unnecessary prostate biopsies, excessive cost, and treatment burden. Therefore, PSA density (PSAD) and multiparametric magnetic resonance imaging (mp-MRI) of the prostate are becoming common. In this study, we aimed to investigate the predictiveness of PSAD and mp-MRI of the prostate in the diagnosis of prostate cancer, which are non-invasive diagnostic methods. Materials and Methods: The files of 193 patients who applied to the urology outpatient clinic for approximately 5 years were reviewed and evaluated retrospectively. Serum PSAD values and prostate imaging reporting and data system (PIRADS) scores were recorded. Prostate biopsies were performed. The cut-off value for PSAD was 0.15 ng/mL/cc. Patients with <0.15 were divided into group 1, and those with >= 0.15 were divided into group 2. Patients with a PIRADS score of 3 were divided into the suspicious group, and patients with a PIRADS score of 4 or 5 were divided into the risky group. Results: Prostate volume, PSA, and PSAD were significantly different between the benign and malignant groups. PSAD was positively correlated with the PIRADS score. Of the 123 patients with a PIRADS score of 3, 82.9% had benign prostatic enlargement (BPE) and 17.1% had prostate cancer. Of the 70 patients with a PIRADS score of 4 or 5, 45.7% had BPE and 54.3% had prostate cancer (p<0.001). Clinically significant prostate cancer rates were significantly different between the PSA score groups and were also different for PIRADS (p<0.001). The sensitivity and specificity of PSAD in the diagnosis of prostate cancer were 67.8% and 64.9%, respectively. The sensitivity and specificity of the PIRADS score in the diagnosis of prostate cancer were 64.4% and 76.1%, respectively. When these two parameters were used in combination, the specificity was 87.3% and the sensitivity was 81.4% in the presence of at least one. Conclusion: According to the data of the study, it was concluded that PSAD and PRIDAS scores are complementary diagnostic methods in the diagnosis of prostate cancer and are indispensable elements in the diagnosis. PSAD and PRIDAS scores are important diagnostic parameters in making the biopsy decision in the diagnosis of prostate cancer and help to prevent unnecessary prostate biopsies.Öğe Diagnostic Role of Intravesical Prostatic Protrusion and Visual Prostate Symptom Score in Lower Urinary Tract Symptoms in Male(2023) Saygın, Hüseyin; Ergin, İsmail Emre; Öztürk, Abuzer; Asdemir, Aydemir; Velibeyoğlu, Arslan Fatih; Korgalı, EsatIntroduction In this study, it was aimed to evaluate non-invasive, effective and low-cost diagnostic methods of bladder filling and voiding abnormalities in male patients. Materials and Methods: Patientswere admitted between March 2020 and August 2020. Visual Prostate Symptom Score (VPSS) and the International Prostate Symptom Score (IPSS) were completed by the patients. Patients’ intravesical prostatic protrusion (IPP), prostate volume, and post voiding residual urine (PVR) were measured by suprapubic ultrasound. Bladder Outlet Obstruction Number (BOON)was used to calculate urethral resistance. Patients with a BOON value above -20 were considered obstructive. Results: This study included 219 male patients aged 50 years and over. The number of patients with a BOON value over -20 were 34 (obstructed) and below -20 were 61 (non-obstructed). There was a significant difference between these two groups in terms of PSA, prostate volume, IPP, Qmax, PVR, IPSS, and VPSS. It was observed that IPSS and VPSS were correlated (r=0.786). Obstructive (r=0.779) and irritative symptoms (r=0.813) of IPSS and VPSS were also observed to be correlated. Conclusion: VPSS was found to be equivalent to IPSS in the diagnosis of lower urinary tract symptoms. IPP is an important, practical and non-invasive method that correlates with IPSS, VPSS and BOON.Öğe Digit Length Ratio as an Indicator of Fetal Androgen Levels: Relationship to Prostate Volume-Related Men Lower Urinary Tract Symptoms(Wiley, 2025) Ergin, Ismail Emre; Ozturk, Abuzer; Asdemir, AydemirObjective: This study aimed to investigate the relationship between the 2nd and 4th digit ratios, which are associated with fetal androgen exposure, and prostate volume and testosterone levels, both of which are linked to lower urinary tract symptoms (LUTS). Methods: Male patients presenting to our urology clinic with increased prostate volume and LUTS were categorized into two groups: those with BPH and those without (non-BPH). For both groups, the right-hand 2D:4D finger ratio, testosterone levels, prostate volume, uroflow parameters, and IPSS scores were recorded. Results: The 2D:4D ratio, prostate volumes, Qmax, and IPSS scores differed significantly between the BPH and non-BPH groups (p = 0.023, 0.002, 0.000, 0.001). No significant difference was observed in total testosterone levels between the groups (p = 0.381). The 2D:4D ratio was negatively correlated with prostate volume and IPSS (r = -0.389, -0.308) and positively correlated with Qmax (r = 0.301). Conclusions: Our study demonstrates that the 2D:4D ratio is a straightforward and effective tool for assessing BPH patients, as it correlates with the severity of LUTS symptoms. This non-invasive measure offers potential value in evaluating LUTS, and with age standardization, it could be applied more broadly across age groups. Further large-scale studies are needed to refine its standardization and expand upon current findings.Öğe Effects of psoriasis and metabolic syndrome on male sexual functions(Imr Press, 2021) Saygin, Huseyin; Tosun, Mustafa; Ozturk, Abuzer; Ergin, Ismail Emre; Kirac, Emre; Asdemir, Aydemir; Velibeyoglu, Arslan FatihBackground and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis. Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded. Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = -0.405, -0.217 and -0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment. Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.Öğe Evaluation of incidental prostate cancer in patients who underwent radical cystectomy and its effect on survival(Adıyaman Üniversitesi, 2024) Öztürk, Abuzer; Ergin, İsmail Emre; Saygın, Hüseyin; Asdemir, AydemirAim: Our study aimed to investigate the incidence of incidental prostate adenocarcinoma, its histopathological results and its effect on survival in patients who underwent radical cystectomy due to bladder tumor. Materials and Methods: Patients who underwent radical cystectomy with a diagnosis of bladder tumor in our clinic in the last ten years and who had no preoperative suspicion or diagnosis of prostate cancer were included in the study. Patients were divided into two groups those with and without incidentally prostate cancer. Both groups were compared in terms of age, PSA value, histopathological features and overall survival. Results: 15 (22.6%) of 79 patients who underwent radical cystectomy and were followed up for an average of 62 months were incidentally diagnosed with prostate adenocarcinoma. There was a significant difference between mean PSA value in patients with prostate cancer and the group without prostate cancer (p=0.004). When we evaluated it in terms of five-year overall survival, no significant difference was found between the two groups. Conclusion: Although incidental prostate cancer does not seem to affect survival, it is necessary to follow up regularly in the presence of prostate cancer and be more careful, especially in the presence of locally advanced prostate cancer.Öğe Fluoroquinolone Resistance Level in Rectal Swab Taken Before Transrectal Ultrasound Prostate Biopsy(Galenos Publ House, 2022) Saygin, Huseyin; Ozturk, Abuzer; Asdemir, Aydemir; Ergin, Ismail Emre; Velibeyoglu, Arslan Fatih; Kirac, Emre; Hasbek, MursitObjective: It has been shown that antibiotic prophylaxis before transrectal ultrasound prostate biopsy (TRUS-Bx) reduces the incidence of post-biopsy infectious complications. Without the superiority of a particular antibiotic regimen, there are differences in the antibiotic regimens used by clinics. However, recently, there have been serious concerns about TRUS-Bx-related infectious complications due to the increase in fluoroquinolone (FQ)-resistant bacterial strains. To overcome this global problem, alternative antibiotic prophylaxis should be investigated and appropriate antibiotic management should be applied in patients who will undergo TRUS-Bx. This study aimed to determine the antibiotic susceptibility of the rectal flora based on rectal cultures before TRUS-Bx, to systematically determine the basic prevalence of FQ resistance, to investigate the relationship between FQ resistance and the risk of infection after TRUS-Bx, and to determine the susceptibility of Fosfomycin and trimethoprim-sulfamethoxazole (TMP-SMX) as an alternative to the FQ group.Materials and Methods: Rectal swab cultures were taken from each patient to undergo TRUS-Bx two days before the procedure. Two daily doses of 500 mg ciprofloxacin were given orally for one week, starting one hour before the procedure. All patients underwent 12 core biopsies.Results: Antibiograms obtained from rectal swabs showed sensitivity to FQ in 78 patients (89.7%), to Fosfomycin in 85 patients (97.7%), to TMP-SMX in 78 patients (89.7%).Conclusion: Although different antibiotic prophylaxis methods are discussed due to FQ resistance in today's medical practices, FQ sensitivity continues at a high rate of 89.7% in our region and still seems to be a viable prophylaxis method.Öğe Giant prostatic urethral stones in a young patient(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Saygin, Huseyin; Korgali, Esat; Asdemir, Tugba YildizGiant prostatic urethral stones have been reported as a very rare entity, and the etiology of these stones is not clear. Here we report a case of a 44-year-old man with giant multiple prostatic urethral stones presented with voiding difficulty and recurrent urinary tract infections. A big stone in the right cavity was observed endoscopically, some of them protruding into the urethra, and two other big stones in the left cavity were observed after resection of the surface tissue on the stones on the prostate. Following cystoscopy, giant prostatic stones were removed endoscopically after holmium-YAG laser lithotripsy.Öğe HIV-negatif hastada penil kaposi sarkomu: Olgu sunumu(2023) Öztürk, Abuzer; Ergen, İsmail Emre; Asdemir, Aydemir; Öztürk, Nisa Begüm; Saygın, HüseyinKaposi sarkomu, sıklıkla immünsuprese hastalarda görülen enflamatu- var vasküler bir tümördür. Burada insan immünyetmezlik virüsü (HIV) negatif, immünsupresif tedavi almayan bir hastada saptanan glans penis tutulumlu bir Kaposi sarkomu olgusu sunulmuştur. Altmış dokuz yaşın- da glans peniste mor renkli nodüler lezyon ile başvurdu. Lezyonun eksiz- yonei biyopsi incelemesinde Kaposi sarkomu tanısı konuldu. Antitümör tedavi verilmeyen hasta on aydır hastalıksız izlemdedir. Sonuç olarak, penisin nonspesifik lezyonlarının ayırıcı tanısında hasta HIV negatif olsa da Kaposi sarkomu akılda bulundurulmalıdır.Öğe Late diagnosed congenital anterior urethral diverticulum in a male teenager: A case report(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Saygin, Huseyin; Korgali, Esat; Cicek, ResulIn this case report we present the case of an 18-year-old boy with a congenital anterior urethral diverticulum. This is a rare condition in males which can lead to obstructive lower urinary tract symptoms and urosepsis. Diagnosis is made by urethroscopy and radiological imaging. Surgical treatment can be open or endoscopic. Long-term follow up is required to check for reoccurrence of the obstruction.Öğe Macro hematoma after micro percutaneous nephrolithotomy: A case report(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Saygin, Huseyin; Korgali, Esat; Cicek, ResulThe micropercutaneous nephrolithotomy (mPNL, microperc) method was developed in order to prevent complications. In our clinic, we performed microperc on a 39-year-old man who expelled renal stone. During the microperc procedure, lower pole calyceal access was successfully obtained to get direct access to the stone by using 4.8Fr microperc needle. The patient's hemoglobin dropped from 16.8 to 9.6 gr/dl about 6 hours after surgery. A new computerised tomography (CT) scan demonstrated a large retroperitoneal hematoma measuring 182x97x92 mm. When we performed retroperitoneal exploration, we saw a bleeding area due to the entrance of microperc needle. Then, we controlled the hemorrhage. The patient's hemodynamics remained stable and he did not need any blood transfusion after exploration. Based on this case, it appears reasonable to allow open surgery after microperc to control macro hematoma.Öğe Metabolome in urology practices: Signatures in plasma and urine(Nova Science Publishers, Inc., 2023) Asdemir, AydemirComparing the vast variation in biochemical processes seen in tumor cells with normal cells can be considered the initiation of metabolomics research, which is now used in different medical fields. Currently, there is an undisputed need for clinically relevant biomarkers that can be used for the diagnosis and prognosis of urologic cancer types, e.g., prostate, bladder, and metabolomics can be considered promising at this stage. Novel and relevant biomarkers are required for specialized diagnosis, monitoring, and treatment of a particular disease, which would also contribute to the improvement, enhancement, and personalization of a designed therapy. While considerable progress has been made in determining important biomarkers, more challenges remain to be solved for the further integration of metabolomics into clinical practices. This chapter reviews relevant metabolomics research conducted in the field urology. © 2023 Nova Science Publishers, Inc. All rights reserved.Öğe Microperc Versus Miniperc for Treatment of Renal Stones Smaller Than 2 cm in Pediatric Patients(UROL & NEPHROL RES CTR-UNRC, 2016) Dundar, Gokce; Gokce, Gokhan; Gokcen, Kaan; Korgali, Esat; Asdemir, Aydemir; Kaygusuz, KenanPurpose: Pediatric stone disease is an important clinical problem in pediatric urology practice. We aimed to compare mini-percutaneous nephrolithotomy (miniperc) and micro-percutaneous nephrolithotomy (microperc) in pediatric patients who underwent unsuccesful SWL procedure. Materials and methods: A number of 43 pediatric patients, aged 17 years or younger, were treated with miniperc or microperc procedures due to renal calculi by a single surgeon. In group 1, there were 27 patients who underwent miniperc procedure. In group 2, 16 patients were treated by microperc. Results: Mean age of the patients were 9.5 (3-17) years in group 1 and 7.9 (2-16) years in group 2 (P = .25). Stone burden was similar between the two groups. Mean operation duration was 74.1 (40-110) minutes in miniperc group and 37.2 (20-55) minutes in microperc group (P < .01). Patients who underwent microperc were discharged from clinic earlier. Hyperthermia without bacteraemia was observed in 2 children in the miniperc group and was treated by using a single dose of paracetamol and also 2 children in the same group needed blood transfusion. There was a tendency for low haemoglobin decrease in microperc group compared to miniperc (P > .05). Conclusion: The management of pediatric stone disease has evolved with improvements in techniques and minimalisation of surgical instruments and thus, it can be effectively and safely used in children by experienced surgeons.Öğe Mobile app communication to prevent ER visits post-circumcision: a prospective observational study(Springer, 2025) Sanci, Adem; Ergin, Ismail Emre; Ozturk, Abuzer; Asdemir, AydemirPurpose To assess the impact of a mobile phone application facilitating real-time visual and verbal communication on reducing emergency-room admissions following circumcision. Methods This prospective observational study included circumcision surgeries performed by one surgeon at our clinic between April and June 2024, after obtaining parental consent. Parents were divided into two groups: one received a mobile app phone number, while the other did not. The mobile app group was based on parents' communication needs, such as distance or socioeconomic factors. Follow-up appointments were scheduled for one week and one month; the mobile app group had follow-ups via the app, while the non-communicating group followed up in person. WhatsApp was used due to its cost-effectiveness and accessibility. Data on emergency visits, communications, and complications were recorded prospectively and analyzed retrospectively using SPSS with t tests and Mann-Whitney U tests (p < 0.05). Results A total of 200 patients were enrolled, with 162 meeting the inclusion criteria. The study was divided into two groups: 'Communicating group' (Group 1, 75 patients) had access to the mobile app, while 'Non-communicating group' (Group 2, 87 patients) received routine post-operative instructions. No significant differences in age or weight were found. The most common complications included wound infection, non-healing wounds, swelling, bleeding, and micturition issues. Emergency visits were significantly higher in Group 2 (12.64%) compared to Group 1 (1.33%) (p = 0.01). Conclusion The use of a mobile app for post-surgical communication may significantly reduce emergency-room visits following circumcision.Öğe Molecular mechanism of anticancer effect of heat shock protein 90 inhibitor BIIB021 in human bladder cancer cell line(Springer, 2024) Asdemir, Aydemir; Ozgur, AykutBladder cancer is a type of urologic malignancy that exhibits significant morbidity, mortality, and treatment costs. Inhibition of heat shock protein 90 (HSP90) activity has been a promising pharmacological strategy for blocking of bladder cancer pathogenesis. BIIB021 is a next-generation HSP90 inhibitor which interrupts ATP hydrolysis process of HSP90 and inhibits the stabilization and correct folding of client proteins. In current study, we aimed to investigate the molecular mechanism of the anticancer activity of BIIB021 in human bladder cancer T24 cells. Our results revealed that nanomolar concentration of BIIB021 decreased viability of T24 cell. BIIB021 downregulated HSP90 expression in T24 cells and inhibited the refolding activity of luciferase in the presence of T24 cell lysate. PCR array data indicated a significant alteration in transcript levels of cancer-related genes involved in metastases, apoptotic cell death, cell cycle, cellular senescence, DNA damage and repair mechanisms, epithelial-to-mesenchymal transition, hypoxia, telomeres and telomerase, and cancer metabolism pathways in T24 cells. All findings hypothesize that BIIB021 could exhibit as effective HSP90 inhibitor in the future for treatment of bladder cancer patients.Öğe Predicting Response to Androgen Deprivation Therapy and Resistance to Castration in Metastatic Prostate Cancer(2024) Öztürk, Abuzer; Ergin, İsmail Emre; Asdemir, Aydemir; Saygın, HüseyinObjective: We sought to identify predictive factors affecting time to castration resistance in metastatic prostate cancer patients receiving androgen deprivation therapy (ADT). Materials and Methods: We retrospectively evaluated 47 patients who received ADT with the diagnosis of metastatic prostate cancer. The patients\" age, International Society of Urological Pathology (ISUP) scores, baseline prostate specific antigen (PSA), alkaline phosphatase (ALP) value, prostate-specific membrane antigen (PSMA) tracer expression, represented by the maximum standardised uptake value (SUV max) at diagnosis, nadir PSA value, and time to resistance to ADT were recorded. Results: All patients included in the study were resistant to treatment with ADT. The mean age of the patients was 70.81 ± 1.15 years. The mean time to develop resistance to treatment after castration was 31.51 ± 4.9 months. In the correlation analysis, a significant negative correlation was detected between PSA, nadir PSA values and time to treatment resistance. The relationship between the SUVmax value of the primary prostate lesion, ALP value at the time of diagnosis and time to response to ADT developed was not significant. Conclusion: We found PSA values at diagnosis and nadir PSA values during follow-up to be predictive factors of treatment resistance in metastatic prostate cancer patients receiving ADT.
