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Öğe Analysis of corneal densitometry and endothelial morphometry in patients with psoriasis(Elsevier, 2021) Yeter, Duygu Yalinbas; Bozali, Erman; Apa, Anil Selim; Tosun, MustafaBackground: To evaluate corneal endothelial properties and corneal densitometry values in patients with psoriasis and to compare the results with those of healthy controls. Methods: This prospective, comparative, and cross-sectional study included 106 eyes of 53 patients who were diagnosed with psoriasis and 106 eyes of 53 age-gender matched healthy controls. All patients were evaluated in terms of ocular surface tests such as Schirmer-1 and tear break-up time (TBUT). Corneal endothelial measurements were performed using noncontact specular microscopy. Corneal tomographic and densitometric measurements were obtained using the Scheimpflug imaging system. Measurements were also evaluated according to the psoriasis area and severity index (PASI) score. Results: The mean TBUT and Schirmer 1 test values were significantly lower in the psoriasis group than in the healthy controls (p = 0.02, p < 0.001, respectively). While the mean endothelial cell density was significantly lower in patients with psoriasis than the healthy controls (2389.9 +/- 314.9 cells/mm2 vs. 2512.4 +/- 289.7 cells/ mm2, p = 0.02), the mean average endothelial cell area, standard deviation of cell area, coefficient of variation of cell area were significantly higher in patients with psoriasis (426.6 +/- 62.7 mu m2 vs. 403.2 +/- 46.1 mu m2, p = 0.01; 206.4 +/- 52.3 mu m2 vs. 183.2 +/- 43.8 mu m2, p = 0.006; and 48.1 +/- 6.3% vs. 45.7 +/- 6.7%, p = 0.04, respectively). Most of the densitometry measurements in concentric zones were higher in patients with psoriasis than in healthy controls, but none of the differences reached statistical significance. Conclusions: A regular eye examination is crucial in patients with psoriasis because corneal structural and functional changes, particularly endothelial alterations, are of utmost importance in planning intraocular surgeries in patients with psoriasis.Öğe Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography - A Predictor of Visual Acuity in Schizophrenia(Georg Thieme Verlag Kg, 2022) Bozali, Erman; Yalinbas, DuyguBackground The aim of this study was to evaluate the thickness of the outer retinal layer (ORL) together with macular thickness and changes in the retinal nerve fiber layer (RNFL) in patients with schizophrenia in comparison with healthy controls. Methods This study included 114 eyes of 57 patients diagnosed with schizophrenia and 114 eyes of 57 healthy controls. Central foveal thickness (CFT), central macular thickness (CMT), and ORL thickness were measured in both groups via the images obtained by spectral-domain optical coherence tomography (SD-OCT). RNFL was also assessed in four quadrants (inferior, superior, temporal, nasal). CMT measurements were presented as the average thickness of the macula in the central 1 mm area on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. The ORL thickness was defined as the distance between the external limiting membrane and retinal pigment epithelium at the center of the foveal pit. Results The mean age of 57 patients was 37 +/- 10 years, of whom 34 (60%) were male and 23 (40%) female. No statistically significant difference was found between groups in terms of age and gender (p = 0.8 for age, p = 0.9 for gender). There was no statistically significant difference in the mean CMT between the two groups (p = 0.1). The mean ORL thickness in the two groups was 99.8 +/- 8.3 and 103.7 +/- 6.2, respectively, and was significantly decreased in the schizophrenia group (p = 0.005). RNFL analysis demonstrated significant thinning in the inferior and superior quadrants compared to healthy controls (p < 0.001 and p = 0.017, respectively). Conclusions SD-OCT findings - especially ORL and RNFL thickness - may be related to the neurodegenerational changes in schizophrenia.Öğe Assessment by the Scheimpflug imaging system of corneal clarity and anterior segment properties in rosacea patients(Elsevier Science Inc, 2024) Bozali, Erman; Yeter, Duygu Yalinbas; Tosun, Mustafa; Apa, Anil SelimObjective: To evaluate the effects of rosacea on ocular surface changes such as alterations in dry eye parameters, corneal densitometry, and aberrations, in comparison with healthy controls. Methods: A total of 88 eyes of 44 patients diagnosed with rosacea and 88 eyes of 44 healthy controls were enrolled in this cross-sectional study. All participants underwent a comprehensive dermatologic and ophthalmic examination and Tear Break-Up Time (TBUT) and Schirmer-1 tests were performed. The rosacea subtype and Demodex count and OSDI scores of all participants were recorded. Corneal topographic, densitometric, and aberrometric measurements were obtained using the Scheimpflug imaging system. Results: The mean age of the 44 patients was 41.2 +/- 11.0 years of whom 31 (70.5%) were female. The mean TBUT and Schirmer-1 test values were significantly decreased and OSDI scores were significantly increased in the rosacea group compared to healthy controls (p < 0.01 for all). The most common subtype of rosacea was erythematotelangiectatic rosacea (70.4%). The severity grading of rosacea revealed that 18 (40.9%) patients had moderate erythema. The median (min-max) Demodex count was 14.0 (0-120) and the disease duration was 24.0 (5-360) months. The comparison of the corneal densitometry values revealed that the densitometry measurements in all concentric zones, especially in central and posterior zones were higher in rosacea patients. Corneal aberrometric values in the posterior surface were also lower in the rosacea group compared to healthy controls. The topographic anterior chamber values were significantly lower in the rosacea group.Öğe Behçet hastalığı’nda optik koherens tomografi ile makula koroidal kalınlığının değerlendirilmesi(Cumhuriyet Üniversitesi, 2015) Bozali, Erman; Erdoğan, HaydarBu çalışma, Behçet Hastalığı'nda Optik Koherens Tomografi (OKT) ile fovea kalınlığı ve makula koroidal kalınlığının değerlendirilmesi amacıyla yapıldı. Behçet hastalığı tanısı olan 30 hasta grup 1 olarak, oftalmolojik muayenesinde herhangi bir patoloji saptanmayan 30 birey ise grup 2 olarak alındı ve iki grubun ayrıntılı oftalmolojik muayenesi yapılıp OKT yardımıyla makula koroidal kalınlıkları karşılaştırıldı. Grup 1'de 19 kadın, 11 erkek; Grup 2'de 15 kadın, 15 erkek vardı. Cinsiyet açısından iki grup arasında istatistiksel olarak anlamlı fark tespit edilmedi (p>0,05). Grup 1'deki hastaların ortalama yaşı 36,16±11,85 iken Grup 2'deki ortalama yaş 35,10±7,58 idi. İki grup arasında yaş ve cinsiyet bakımından istatistiksel fark tespit edilmedi (p>0,05). Çalışmamızda arka segment tutulumu olan BH olgularında fundoskopi ile fark edilemeyen değişikliklerin SD-OKT ile tespit edildiği görüldü. SD-OKT ile değerlendirilen IS/OS bandı yapı bütünlüğündeki bozulmanın GK üzerine en fazla etkiye sahip olduğu saptandı (KW=31,14; p=0,001). Çalışmanın sonucunda, Behçet hastalarında sağlıklı insanlarla karşılaştırıldığında fovea kalınlığı ve makula koroidal kalınlığının artmış olduğu tespit edildi.Öğe Blefaropitozis Cerrahisinde Demografik ve Klinik Özelliklerin Değerlendirilmesi: Tek Merkez 10 Yıllık Sonuçlar(2021) Yeter, Duygu Yalınbaş; Bozali, Erman; Dursun, Demet; Ozec, Ayse Vural; Erdogan, HaydarAmaç: Blefaropitozis cerrahisinde klinik, demografik özellikler ve cerrahi yaklaşımı tek merkez, on yıllık veriler doğrultusunda değerlendirmek. Gereç ve Yöntem: Bu geriye dönük çalışmada, 2010-2020 tarihleri arasında blefaropitozis tanısı konup cerrahi geçiren hastaların dosyaları tarandı. Hastaların pitozis derecesi, preoperatif ve postoperatif levator fonksiyonu, marjin refle mesafesi, vertikal kapak aralığı ve cilt kıvrımı ölçümleri, yapılan cerrahiler, komplikasyonlar, takip süreleri ve cerrahi başarı oranları kaydedildi. Bulgular: Çalışmaya 72’si erkek, 51’i kadın olmak üzere 123 hastanın 153 gözü dahil edildi. Hastaların 51’inde (%41) kazanılmış pitozis, 72’sinde (%59) konjenital pitozis mevcuttu. Kazanılmış pitozis grubunda 5’i travmatik olmak üzere hepsi aponörotik pitozisti. Konjenital pitozis grubunda ise Marcus Gunn fenomeni olan bir hasta dışında hepsi basit konjenital pitozisti. Kazanılmış pitozis grubunda en sık uygulanan cerrahiler levator aponöroz onarımı (%59) ve levator rezeksiyonu (%41), konjenital pitozis grubunda is levator rezeksiyonu (%57) ve frontal askı (%42) cerrahisiydi. En yüksek başarı oranları hem konjenital hem de kazanılmış pitozis grubunda levator rezeksiyonu cerrahisinde izlendi (sırasıyla %85 ve %82). Sonuç: Blefaropitozis cerrahisinde başarılı bir cerrahi sonuç için doğru cerrahi planlama en önemli basamaktır. Levator fonksiyonu kötü olmayan gözlerde tercih edilen levator rezeksiyonu cerrahisi hem kazanılmış pitozis hem de konjenital pitozis grubunda en başarılı yöntemdir.Öğe Comparison of photoscreeners and hand-held autorefractometer with cycloplegic autorefractometry in children with newly diagnosed attention deficit hyperactivity disorder(Pamukkale University, 2023) Yeter, Duygu Yalınbaş; Bozali, Erman; Kara, Caner; Sarı, Seda Aybüke; Dursun, DemetPurpose: To compare non-cycloplegic refraction measurements of two photoscreeners and the hand-held autorefractometer with cycloplegic measurements of the autorefractometer in patients with attention deficit hyperactivity disorder (ADHD). Meterials and methods: This cross-sectional, comparative study consisted of 53 children who were newly diagnosed with ADHD. We compared spherical, cylindrical, cylindrical axis and spherical equivalent (SE) measurements in Plusoptix A12, Spot Vision Screener, and Retinomax K-plus Screen with Tonoref II. Reliability was analyzed by using the interclass correlation coefficient (ICC) and Bland-Altman plot was used to evaluate the agreement between devices. Results: The mean age of children was 9.45±1.68. All of the devices measured spherical power and SE significantly more myopic than the Tonoref II. While The Spot Vision Screener, PlusoptiX A12, and Tonoref II provided similar cylindrical power, Retinomax K-plus Screen measured significantly lower than the Tonoref II. The excellent reliability was detected in spherical power, cylindrical power, SE and J0 between Tonoref II and PlusoptiX A12 (ICC:0.930, 0.921, 0.927 and 0.920, respectively. All of the hand-held devices showed excellent reliability in terms of cylindrical power and J0 (ICC>0.90, for all) and good reliability for J45 (ICC:0.75-0.90 for all). Conclusion: Despite all devices having advantages or disadvantages, Plusoptix A12 showed excellent reliability for detecting refractive errors in children with ADHD. © 2023, Pamukkale University. All rights reserved.Öğe Comparison of Self-Esteem and Social Anxiety Levels of Adolescents Who Wear Spectacles and Who Do Not(2021) Yeter, Duygu Yalınbaş; Bozali, Erman; Çiçek, Ayla UzunIntroduction: Self-esteem and social anxiety could affect both the social life and school success of adolescents. Wearing spectacles in adolescence may be related to self-esteem and social anxiety. Therefore, in this study, we aimed to compare the level of self-esteem and social anxiety between adolescents who wear spectacles and those who do not. Methods: This comparative descriptive study which was conducted in Sivas Cumhuriyet University Ophthalmology outpatient clinic between March-July 2021, consisted of 108 adolescents who have been wearing spectacles for at least one year, and age and sex-matched, 150 healthy adolescents. Self-esteem was measured by Rosenberg Self-esteem Scale and social anxiety was measured by Social Anxiety Scale for Children-Revised. The socio-demographic characteristics of the participants and clinical data on spectacle were evaluated via a sociodemographic data form. Results: 69 (63.9%) of the study group were girls, and the mean age was 12.92±1.55 years. For the right eyes, the mean spherical equivalent (SE) value was - 1.10±3.23 D and it was -1.15±3.39 D for the left eyes. The mean self-esteem scores of the spectacle wearers were significantly lower (22.53±4.60 vs. 25.50±2.05, p<0.001), and the mean social anxiety scale scores were significantly higher (40.23±10.90 vs. 36.13±7.57, p=0.006) compared the control group. When the patients were evaluated as myopic (n=78) and hyperopic (n=30) regarding the SE, even though there was an increase in the social anxiety score as the degree of myopia increased for both eyes (for right, r=.-280, p=0.01, and for left, r=.-235, p=0.04), there was no significant correlation with self-esteem scores (p>0.05). Conclusion: Wearing spectacles in adolescence seems to be related to self-esteem and social anxiety. An appropriate approach would be to perform a thorough psychological evaluation of adolescents who wear spectacles.Öğe Evaluation of contrast sensitivity in patients with congenital red-green color vision deficiency(Springer, 2024) Karatepe, Mustafa Salih; Bozali, ErmanPurpose To evaluate mesopic and photopic contrast sensitivity in patients with congenital red-green color vision deficiency regarding with and without glare conditions and to compare these findings with age- and gender-matched healthy controls with normal color vision. Methods Patients with congenital red-green color vision deficiency and age- and gender-matched healthy controls were included in this cross-sectional comparative study. Contrast sensitivity measurements were taken from all subjects in 4 different conditions; binocular mesopic-without glare, mesopic-with glare, photopic-without glare, photopic-with glare, and the results were compared. Results Twenty one patients with color vision deficiency (13 deuteranopic, 8 protanopic) and 22 age- and gender-matched healthy controls were included in the study. The mean age was 35.2 +/- 13.5 years in the protan group, 30.6 +/- 7.7 years in the deutan group, 32.0 +/- 8.8 years in the control group, and there was no significant difference in age between the groups (P > 0.05). The mean mesopic and photopic contrast sensitivity values of the groups at all spatial frequencies (1.5, 3, 6, 12, 18 cpd) were not statistically significant when evaluated by the multifactor repeated measures test of ANOVA to evaluate the effect of light conditions (with and without glare) (P > .05). Conclusion Mesopic and photopic contrast sensitivity values of patients with congenital red-green color vision deficiency were similar to healthy controls regarding with and without glare conditions.Öğe Evaluation of Foveal Thickness and Macular Choroidal Thickness with Optical Coherence Tomography in Behcet's Disease(Marmara Univ, Inst Health Sciences, 2021) Bozali, Erman; Erdogan, Haydar; Dursun, Ayhan; Ozec, Ayse Vural; Toker, Mustafa Ilker; Arici, Mustafa KemalObjective: To evaluate the foveal thickness and macular choroidal thickness on patients who were diagnosed with Behcet's Disease (BD). Methods: A total of 60 patients were included in this prospective cross-sectional study. Patients were divided into two groups. Group 1 consisted of 30 patients who were diagnosed with BD and Group 2 consisted of 30 healthy controls. Detailed ophthalmological examination was performed on both groups and foveal thickness and macular choroidal thickness were measured with Spectral-Domain Optical Coherence Tomography (SD-OCT). To measure the choroidal thickness enhanced depth imaging OCT (EDI-OCT) technique was used. Results: Mean foveal thickness in BD patients was 216.06 +/- 53.14 mu m and mean subfoveal choroidal thickness was 363.21 +/- 85.22 mu m. Mean foveal thickness and subfoveal choroidal thickness in healthy controls was 211.65 +/- 16.60 mu m and 352.83 +/- 87.11 mu m respectively. There was no statistical significance between patients with BD and patients of the control group regarding foveal and subfoveal choroidal thickness. However, anatomical deformation of Ellipsoid Zone structure in OCT had the most effect on visual acuity (p=0.001). Conclusion: This study shows that there was no statistically significant difference in terms of foveal thickness and macular choroidal thickness in patients with BD.Öğe Evaluation of the corneal morphologic and topographic alterations in patients with Bell's palsy(Pamukkale University, 2022) Bozali, Erman; Yeter, Duygu Yalınbaş; Çiftçi, Merve; Bora, AdemPurpose: To evaluate the effects of ocular surface changes that may develop due to Bell's palsy (BP) on dry eye parameters, corneal densitometry values, and aberrations in patients with unilateral BP and compare them with sound eyes. Materials and methods: A total of 33 eyes of 33 patients diagnosed with unilateral BP and 33 sound fellow eyes of the patients were enrolled in this study. A complete ophthalmologic examination including best-corrected visual acuity (BCVA), intraocular pressure measurement, slit-lamp biomicroscopy to observe superficial punctate keratopathy (SPK), tear break-up time (TBUT) test, and detailed fundoscopic examination was performed for all patients. The corneal topographic, densitometric, and aberrometric measurements were performed using the Pentacam Scheimpflug imaging system. Results: The mean age of 33 patients was 54.9±14.7 years of whom 19 (57.6%) were female; 14 (42.4%) were male. According to the House-Brackmann scale, the majority of the patients had grade II facial nerve palsy. The BCVA in the affected eye was lower and 0.74±0.23 compared to 0.87±0.21 in sound eyes (p=0.029). The mean TBUT was lower and 6.0±4.7 in eyes affected by BP compared to 8.7±4.0 in sound eyes (p=0.014). The SPK was present in 23 (69.7%) patients. The comparison of the corneal densitometry values revealed that the densitometry measurements in anterior concentric zones were slightly higher in affected eyes. Corneal aberrometric values were also slightly higher in affected eyes. No significant difference was observed between affected and sound eyes in terms of corneal keratometric, densitometric, and aberrometric values (p>0.05, for all). Conclusions: Corneal exposure leading to visual complications, and lowering of the tear production may lead to dry eye in BP patients. The examination of the ocular surface to observe the ocular findings of BP is essential. The main priority of the ophthalmologist is to ensure adequate corneal protection to prevent undesired ocular outcomes. © 2022, Pamukkale University. All rights reserved.Öğe Increased Retinal Vessel Tortuosity Associated With Crimean-Congo Hemorrhagic Fever in Children(Lippincott Williams & Wilkins, 2021) Yalinbas, Duygu; Komurluoglu, Ayca; Bozali, ErmanBackground: To evaluate the ocular symptoms and findings of children diagnosed with Crimean-Congo hemorrhagic fever (CCHF). Methods: In this prospective study, children diagnosed with CCHF who underwent a complete ophthalmologic examination during the hospitalization period were included. Results: Twenty-four children with a mean age of 12.4 +/- 3.6 years were included study. The most common ocular finding was conjunctival hyperemia and was observed in 50% of patients. Nine (37.4%) children had abnormalities in fundus examination. Two (8.3%) of them had dilated retinal veins, and 7 (29.1%) had tortuous retinal vessels. No significant difference was found between mild to moderate and severe disease groups in terms of ocular symptoms and ophthalmologic examination findings (P > 0.05, for all). Conclusions: The increased retinal vessel tortuosity was detected as a fundus examination finding in children with CCHF. Both ophthalmologists and pediatricians should be aware of the various ocular manifestations of CCHF for rapid diagnosis and management.Öğe Intracorneal implantation of a misdirected foldable intraocular lens during phacoemulsification surgery: a case report(Consel Brasil Oftalmologia, 2024) Toker, Mustafa Ilker; Bozali, Erman; Unal, Mustafa; Ozec, Ayse Vural; Erdogan, Haydar| A 59-year-old man presented with a unilateral blurring of vision in his left eye. His left eye's visual acuity was hand movements level. He underwent phacoemulsification surgery, and an intrastromal posterior chamber intraocular lens was implanted. The intrastromal intraocular lens was extracted and a new intraocular lens was implanted. Usinge the Snellen chart, the final best-corrected visual acuity was 20/40. With this case report, we wish to emphasize that a single stepwise clear corneal incision merged with wound-assisted intraocular lens injections can result in intraocular lens misdirection into the corneal stroma. As a result, while performing a misdirected intraocular lens removal, we recommend that the wound be carefully constructed.Öğe Pediatric Open Globe Injury in a University-Based Tertiary Hospital in the Anatolian Region(Marmara Univ, Inst Health Sciences, 2022) Bozali, Erman; Yeter, Duygu Yalinbas; Apa, Anil Selim; Ozec, Ayse Vural; Erdogan, HaydarObjective: Evaluation of the epidemiological and clinical features of pediatric open globe injury.Methods: Medical records of 51 patients under the age of 18 who presented to the emergency department with open globe injury (OGI) between 2009 and 2021 were evaluated retrospectively. Patient demographics, Birmingham Eye Trauma Terminology (BETT) category, pediatric ocular trauma score (POTS), visual acuity (VA), site of injury, and seasonal distribution were evaluated.Results: Of all patients included, 40 (78.4%) were male, 11 (21.6%) were female, and the mean age was 9.6 +/- 5.2 years. Zone I injury was detected in 31 (60.8%) patients. The most common cause of injury was sharp objects such as metal or wood splinters. Of all injuries, 29 (56.9%) occurred outdoors. Ocular trauma occurred more frequently in boys, especially in the summer months. Initial VA was less than 0,1 in 21 (41.2%) of the patients, between 0.1-0.5 in 9 (17.6%) and 0.6 and above in 5 (9.8%) patients. At the final visit, VA was less than 0.1 in 9 (17.6%) patients, 0.1-0.5 in 10 (19.6%) patients, and 0.6 and above in 18 (35.3%) patients. Final VA was related to the Zone and was lower as the Zone increased (p:0.011). VA and POTS scores were positively correlated at the final visit (p=0.001).Conclusion: It is substantial for emergency physicians to have a comprehensive understanding of pediatric globe injuries so that children with suspected ocular trauma should be evaluated by an ophthalmologist to prevent medicolegal problems.Öğe Pediatric Open Globe Injury in a University-Based Tertiary Hospital in the Anatolian Region(Marmara Üniversitesi, 2022) Bozali, Erman; Yeter, Duygu Yalınbaş; Apa, Anıl Selim; Özeç, Ayşe Vural; Erdoğan, HaydarObjective: Evaluation of the epidemiological and clinical features of pediatric open globe injury. Methods: Medical records of 51 patients under the age of 18 who presented to the emergency department with open globe injury (OGI) between 2009 and 2021 were evaluated retrospectively. Patient demographics, Birmingham Eye Trauma Terminology (BETT) category, pediatric ocular trauma score (POTS), visual acuity (VA), site of injury, and seasonal distribution were evaluated. Results: Of all patients included, 40 (78.4%) were male, 11 (21.6%) were female, and the mean age was 9.6±5.2 years. Zone I injury was detected in 31 (60.8%) patients. The most common cause of injury was sharp objects such as metal or wood splinters. Of all injuries, 29 (56.9%) occurred outdoors. Ocular trauma occurred more frequently in boys, especially in the summer months. Initial VA was less than 0,1 in 21 (41.2%) of the patients, between 0.1-0.5 in 9 (17.6%) and 0.6 and above in 5 (9.8%) patients. At the final visit, VA was less than 0.1 in 9 (17.6%) patients, 0.1-0.5 in 10 (19.6%) patients, and 0.6 and above in 18 (35.3%) patients. Final VA was related to the Zone and was lower as the Zone increased (p:0.011). VA and POTS scores were positively correlated at the final visit (p=0.001). Conclusion: It is substantial for emergency physicians to have a comprehensive understanding of pediatric globe injuries so that children with suspected ocular trauma should be evaluated by an ophthalmologist to prevent medicolegal problems.Öğe Purtscher-like Retinopathy Associated with Crimean-Congo Hemorrhagic Fever: A Case Report(Taylor & Francis Inc, 2022) Yalinbas, Duygu; Bozali, Erman; Vural, Ayse; Kocak, Husne; Erdogan, HaydarPurpose: To describe retinal findings and spectral-domain optical coherence tomographic (SD-OCT) features of a patient with Crimean-Congo hemorrhagic fever (CCHF) presenting as Purtscher-like retinopathy. Case report: A 70-year-old woman presented with the emerging bilateral blurring of vision. She had been diagnosed with CCHF one week ago and hospitalized in another hospital for treatment of disease. Fundoscopy of the patient revealed cotton-wool spots, retinal whitening areas, and few retinal hemorrhages in a Purtscher-like configuration in both eyes. Spectral-domain optical coherence tomography revealed inner retinal hyperreflectivity corresponding to the cotton-wool spots in both eyes, and also showed subretinal fluid in the left eye. Without any treatment retinal lesions and inner retinal hyperreflectivity on SD-OCT regressed within one month. Conclusion: Crimean-Congo hemorrhagic fever is known to cause mild ocular disease, and may also cause Purtscher-like retinopathy. It is important to aware of the ocular findings of CCHF.Öğe Relationship between mean platelet volume and central serous chorioretinopathy(SPRINGER, 2017) Dursun, Ayhan; Toker, Mustafa Ilker; Ozec, Ayse Vural; Bozali, Erman; Kirboga, Kadir; Dursun, Feyza Gulac; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa KemalThe aim of this study was to investigate the mean platelet volume (MPV) of patients with central serous chorioretinopathy (CSCR). Thirty patients were included in the study. Thirty healthy volunteers were recruited as the control group. All patients and control subjects underwent complete ocular examination. Hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet count, and MPV of the participants were recorded. Data of patients with CSCR were compared with the control subjects. Patients with CSCR had significantly higher MPV values (9.76 +/- 1.36 fL) compared with the control subjects (8.37 +/- 0.72 fL) (p = 0.004). No significant difference was found in platelet counts between the CSCR group and the control group (259 +/- 53.75 and 243 +/- 52.11 K/Ul, p = 0.253). According to the receiver operator characteristics curve analysis, the optimal cut-off value of MPV to predict the CSCR was > 9.4, with 60.0 % sensitivity and 93.3 % specificity. Our results demonstrated that the MPV values were significantly higher in patients with CSCR. MPV may be used as a predictive tool for identifying risk for CSCR.Öğe The Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response(Taylor & Francis Inc, 2022) Yeter, Duygu Yalinbas; Eroglu, Serap; Sariakcali, Baris; Bozali, Erman; Ozec, Ayse Vural; Erdogan, HaydarPurpose: To determine the association of monocyte-to-high-density lipoprotein ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) with diabetic macular edema (DME) and early anti-VEGF treatment response. Material methods: This was a retrospective and cross-sectional study conducted with 143 patients with diabetes mellitus (53 diabetic retinopathy with DME, 38 diabetic retinopathy without DME, and 52 without diabetic retinopathy). Results: 13.9 was the best cutoff value to predict DME for MHR, and 2 was for NLR (59% and 75% sensitivity and 81% and 59% specificity, respectively). Logistic regression analysis showed that NLR >= 2 and MHR >= 13.9 were significantly associated with DME prediction. However, neither NLR >= 2 nor MHR >= 13.9 was associated with central retinal thickness(CRT) or best corrected visual acuity(BCVA) outcomes after anti-VEGF treatment. On the other hand, increased NLR was associated with inferior CRT outcomes. Conclusion: MHR and NLR were simple and cost-effective biomarkers to predict DME. Moreover, higher NLR may contribute to poor CRT outcomes.
