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  • Küçük Resim Yok
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    Assessing the Efficiency of Intranasal Steroid Treatment in Cases with Eustachian Dysfunction Via the Turkish Version of Eustachian Tube Dysfunction Questionnaire-7
    (Wolters Kluwer Medknow Publications, 2020) Bora, Adem; Durmus, Kasim; Demirkiran, Berat Baturay; Aslan, Yasin; Altuntas, Emine Elif
    Aim: The aim of this study was to evaluate the efficiency of the treatment in the cases, who were diagnosed with Eustachian tube dysfunction (ETD) via history, physical examination, and tympanometry and for whom intranasal steroid treatment was planned to be used before surgical treatment options, by using Eustachian Tube Dysfunction Questionnaire (ETDQ)-7. Materials and Methods: Fifty-five cases, who applied to the otorhinolaryngology outpatient clinic due to the complaints suggesting Eustachian dysfunction such as aural fullness and pressure sensation and for whom the diagnosis of Eustachian dysfunction was considered due to the results of the examination, history, and physical examination, were included in the study. The 3rd and 6th weeks of intranasal steroid treatment ETDQ-7 scores were recorded. Results: ETDQ-7 mean scores of the cases were 2.72 +/- 0.97 at the time of initial diagnosis (minimum-maximum: 1-4.71), 2.31 +/- 0.85 in the 3rd week of the treatment (minimum-maximum: 1-5), and 2.12 +/- 0.78 (minimum-maximum: 1-4, 14) in the 6th week. A statistically significant difference was observed when statistically assessing the ETDQ-7 scores determined at the time of diagnosis and in the 3rd and 6th weeks of the treatment (P < 0.001). When ETDQ-7 scores were assessed based on gender in assessment time, there was a statistically significant difference in the assessment conducted in the 3rd week (P < 0.05; P = 0.039). Conclusion: It is believed that the current study is the first study that evaluates the efficiency of intranasal corticosteroid treatment, which is frequently used by the doctors in daily practice in pharmacotherapy in the cases with ETD from young adult and adult age groups, on the symptoms via ETDQ-7. In addition, the results of the present study indicated that intranasal steroid treatment in early periods caused a significant recovery in the symptoms, however this recovery also reached a plateau after the treatment.
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    Boron-Doped Nano Hydroxyapatite Grafts for Bone Regeneration in Rat Mandibular Defects
    (Springernature, 2024) Demirkiran, Berat Baturay; Inan, Zeynep Deniz Sahin; Hamutoglu, Rasim; Oksuz, Kerim Emre; Hasbek, Zekiye; Altuntas, Emine Elif
    The aim of this study was to evaluate the potential effects of boron-doped nano hydroxyapatite grafts on craniofacial bone regeneration in critical bone defects in the mandibular corpus of rats, in terms of scintigraphic and histopathological aspects. Forty Wistar albino rats, with an average weight of 200-220 g, aged 16-18 weeks, and all male, were used in the study. The rats were randomly assigned to five groups, each containing 8 rats, as follows: group C1 (no procedure applied to the mandible), group C2 (surgical defect created in the mandible but no treatment applied), group nHA (nano hydroxyapatite applied to the surgical defect area), group nHA + B1 (nano hydroxyapatite + 1% boron applied to the surgical defect area), and group nHA + B2 (nano hydroxyapatite + 2% boron applied to the surgical defect area). A standard 4 x 4 mm full-thickness transosseous bone defect was created in the mandibular corpus of all rats, except for those in group C1. The bone defect in the rats in group C2 was left to heal naturally. Nano hydroxyapatite (nHA), nano hydroxyapatite + 1% boron, and nano hydroxyapatite + 2% boron were applied to the surgical defect areas of the other three groups, respectively. Bone scintigraphy was performed on all rats on days 0 (following the surgical procedure) and 28 of the experimental period. At the end of the 28th day, the animals were sacrificed, and tissue samples were collected for histological examination. A standard grading system was used to evaluate fracture healing. When the groups were compared in terms of bone healing histopathological scores, a statistically significant difference was observed between group C1 and the other groups (p < 0.005). In the statistical evaluation made according to the histopathological mean scores, the least improvement was observed in group C2. No statistically significant difference was observed between group nHA and group nHA + B1 and group C2 and between group nHA and group nHA + B1 in terms of bone healing scores (p > 0.005). A statistically significant difference was found between group nHA + B2 and group C2 (p = 0.026). Although there was no statistically significant difference in histopathological scores, the mean score closest to group C1 was observed in group nHA + B2. A statistically significant difference was observed between the groups in the scintigraphic evaluation performed on the 28th day of the experimental procedure, and the difference was between group C1 and group nHA + B1 and between group nHA and group nHA + B1 (p = 0.004; p = 0.028, p < 0.005). In the comparison of the values obtained on days 0 and 28 within the group, a statistically significant change was observed in group nHA + B1 and group nHA + B2 (p < 0.005). When the results of the present study were evaluated, it was thought that the boron-doped nHA graft biomaterials may have positive effects on bone healing. Providing a different perspective for the development of an alternative new treatment modality that can be locally applied in the treatment of fractures a serious and common health problem can be interpreted as an important outcome of the present study. We believe that this study will serve as a preliminary study for more comprehensive future studies on this subject.
  • Küçük Resim Yok
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    Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study
    (Springer, 2023) Bora, Adem; Durmus, Kasim; Inan, Zeynep D. Sahin; Demirkiran, Berat Baturay; Altuntas, Emine E.
    BackgroundTraumatic tympanic membrane (TM) perforations usually heal spontaneously. The aim of this study was to investigate whether the topical application of Triticum Vulgare (TV) in experimentally induced traumatic TM perforations in the rats has a positive effect on wound healing process.MethodsThe rats were randomly assigned to four experimental groups. Drugs were introduced twice a day for 7 days. On the 7th day, specimens were sent for histological examination.ResultsMean values found in group NC in terms of epithelial regeneration mean scores are as follows: fibroblast and collagen density, neovascularization, and density of inflammation cells were lower than all groups (p < 0.05).It was found that reepithelization on the post-perforation 7th day was better in the HO group than the TV group. In terms of the subepithelial fibroblast cells, density of collagen fibers, formation of new veins, and inflammatory cell accumulation, it was observed that the group TV was better than the group HO.ConclusionThis is the first study investigating the potential curative role of TV in an experimental rat model of tympanic membrane perforation. Considering these findings, it is concluded that TV can be more effective than HO on wound healing in TM perforation.
  • Küçük Resim Yok
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    Comprehensive evaluation of deep neck infections: A retrospective analysis of 111 cases
    (Wiley, 2024) Aksoy, Ahmet; Demirkiran, Berat Baturay; Bora, Adem; Dogan, Mansur; Altuntas, Emine Elif
    Purpose: Our study will analyze patients' clinical characteristics, treatment strategies, and complications with deep neck infection (DNI) using their medical records for five years. Methods: The present study included 111 patients diagnosed with DNI in our clinic between January 2018 and March 2023. The patients' complaints at admission, sociodemographic characteristics, season of diagnosis, findings from laboratory tests, radiological imaging performed at the time of first diagnosis, abscess localization, medical and surgical treatment methods used, and complications developing during follow-up were retrospectively examined. Results: The mean age of the patients included in the study was 38.51 +/- 16.92 (6-87 years). There was a significant correlation between chronic disease, smoking behaviours, oral hygiene, and DNI among patients based on their sociodemographic characteristics and medical history (p < .005). DNI development did not differ by season (p > .005). Physical examination findings predominantly revealed neck masses (39.6%) and peritonsillar abscesses (32.4%), and patients with peritonsillar abscesses had a shorter length of hospital stay than those with other localizations. No severe complications occurred during the clinical follow-up. Conclusion: Chronic diseases, smoking, and poor oral hygiene are the primary risk factors for developing DNIs. If an abscess is located in a critical area, it may require extended hospitalization and surgery under general anesthesia. Therefore, addressing these risk factors and encouraging good oral hygiene practices are crucial to preventing DNIs and reducing the need for intensive treatment.
  • Küçük Resim Yok
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    Do Mean Values of the Peak Inspiratory Nasal Flowmeter Vary According to the Severity, Direction and Type of Nasal Septum Deviation?
    (Springer India, 2022) Bora, Adem; Aslan, Yasin; Durmus, Kasim; Demirkiran, Berat Baturay; Altuntas, Emine Elif
    The aim is to investigate the contribution of the PNIF test in daily clinical practices in the objective evaluation of the early postoperative functional results of septoplasty and the effect of the severity, direction, and type of nasal septum deviation on mean PNIF values. Nasal septum deviation (NSDs) of the cases were grouped according to the Mladina classification and the severity of NSDs. An objective evaluation of the nasal airway was conducted via a peak flowmeter device in the preoperative and postoperative first month. When examining the mean PNIF values according to genders, it was observed that the values determined in male cases in the preoperative and postoperative period were higher. In the intragroup evaluation performed according the Mladina classification, a statistically significant increase was observed in the preoperative and postoperative PNIF values of the cases in Types 1-4. In the intragroup evaluation performed according to the severity of NSD, there was a significant increase in the preoperative and postoperative PNIF values of the mild and moderate cases. When comparing the preoperative and postoperative PNIF values of the groups in terms of the severity of NSD, it was observed that there was a significant difference. The PNIF can be used in routine clinical practices to evaluate the septoplasty results objectively. In the evaluation of functional results, the change in the mean PNIF values may also vary according to the direction and severity of septum deviation and the Mladina classification other than age, gender and ethnic origin.
  • Küçük Resim Yok
    Öğe
    İKİNCİ BRANKİYAL YARIK KİSTİ ÖN TANILI HASTALARDA HİSTOPATOLOJİK DOĞRULUK PAYI VE AYIRICI TANISINDA SERVİKAL TÜBERKÜLOZUN ÖNEMİ Histopathological Accuracy in Patients Prediagnosed with Second Branchial Cleft Cyst and the Importance of Cervical Tuberculosis in Differential Diagnosis
    (Yozgat Bozok Üniversitesi, 2025) Doğan, Mansur; Çiftçi, Merve; Özdil, Fikret; Demirkiran, Berat Baturay
    Amaç: Bu çalışmanın amacı, fizik muayene ve görüntüleme yöntemleri ile Brankial Yarık Kisti (BYK) ön tanısı konulan hastaların, cerrahi öncesi ince iğne aspirasyon biyopsi (İİAB) verisi olmadan cerrahi sonrası histopatolojik sonuçların da doğruluk payını araştırmak ve ayırıcı tanılar arsında yer alan servikal tüberkülozun önemini tartışmaktır. Gereç ve Yöntemler: Bir üçüncü basamak Üniversite Hastanesi Kulak Burun Boğaz kliniğinde 2009-2020 yılları arasında boyunda kitle şikayeti ile başvuran ve ön tanısı BYK olan hastaların operasyon sonrası histopatolojik verilerin analizi yapılarak sonuçlar değerlendirildi. Operasyon öncesi İİAB verisi olmayan hastalar çalışmaya dahil edildi. Histopatolojik sonuçları ile ön tanı uyumlu hastalar Grup 1, ön tanı ile uyumlu olmayan hastalar Grup 2 olarak sınıflandırıldı. Retrospektif elde edilen veriler parametrik olmayan testler ile SPSS paket programında analiz edilmiştir. Bulgular: BYK tanısı ile ameliyat edilen 22 erkek, 22 kadın toplam 44 hasta çalışmaya dahil edildi. Toplam 24 hastanın histopatolojik sonucu BYK ile uyumlu idi. Grup 1 olarak değerlendirilen 24 hastanın yaş ortalaması 23 olarak hesaplandı. Hastalar toplam olarak cinsiyetler açısından karşılaştırıldığında anlamlı farklılık izlenmedi (p>0,05). Grup 2’de histopatoloji sonucu tüberküloz olan hastaların yaş ortalaması 58 idi. Gruplar arası istatistiksel olarak anlamlı fark tespit edildi (p=0,020). Sonuç: Boyun kitleleri ile başvuran hastalarda BYK ön tanısının doğrulanması, multidisipliner bir yaklaşım gerektirir. Klinik, radyolojik ve histopatolojik bulguların bir arada değerlendirilmesi, doğru tanı ve tedavi stratejisinin belirlenmesinde hayati önem taşımaktadır. Özellikle ileri yaş hastalarda, tüberküloz gibi enfeksiyöz patolojilerin de dikkate alınması, tanısal gecikmelerin önlenmesine ve tedavinin doğru yönlendirilmesine yardımcı olacaktır.
  • Küçük Resim Yok
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    Investigating dizziness symptom in adult cases with Crimean-Congo hemorrhagic fever using various scales
    (Springer, 2021) Bora, Adem; Buyuktuna, Seyit Ali; Durmus, Kasim; Demirkiran, Berat Baturay; Aslan, Yasin; Oksuz, Caner; Altuntas, Emine Elif
    Background This study was to investigate the frequency of self-reported dizziness symptom in cases with Crimean-Congo hemorrhagic fever (CCHF) and the severity of dizziness, if any, by using various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. Results The frequency of dizziness in CCHF cases included in the study was 11.11% and all the cases were involved in the mild category in terms of disease severity. When the results of the scales applied to all of the cases were evaluated in general, it was seen that there was no vertigo or dizziness. Conclusion According to the results of the present study, we consider that multicenter studies with large series investigating pathophysiological mechanisms underlying these clinical symptoms are needed in order to evaluate dizziness symptom and to make definitive interpretations in CCHF disease.

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