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    Body Composition in Patients with Ankylosing Spondylitis on Anti-Tumor Necrosis Factor Alpha Treatment
    (KUWAIT MEDICAL ASSOC, 2017) Sahin, Ozlem; Kaptanoglu, Ece; Dinler, Mustafa; Dogan, Sevil Ceyhan; Kurt, Kibar Gultekin
    Objectives: To examine the body composition (BC) of the Ankylosing spondylitis (AS) patients on anti-TNF therapy and to evaluate the clinical parameters in obese AS patients Design: Cross-sectional case-control study Setting: Department of Physical Medicine and Rehabilitation, Cumhuriyet University, Medical Faculty, Sivas, Turkey Subjects: Thirty-four AS patients and 34 healthy subjects as controls were included in the study between November 2014 and May 2015 Main outcome measures: Waist circumference (WC), body mass index (BMI), percent body fat (PBF), fat mass (FM) and fat free mass (FFM) were measured in patients and control group. In AS group, disease activity, functional status, spinal mobility and life quality were examined by standard AS questionnaires. Results: WC, BMI, PBF, FM, and FFM were comparable in AS patients and controls. There was a positive correlation between the duration of the anti-TNF treatment and BMI (p = 0.02, r = 0.409). In obese AS patients, the duration of the anti-TNF treatment was significantly longer than the normal weight AS patients (for BMI p = 0.02, for PBF p = 0.03). Obese and normal weight AS patients were comparable regarding disease duration, disease activity, functional status, spinal mobility and life quality. Conclusions: The BC of AS patients on anti-TNF treatment was similar to healthy controls. Anti-TNF treatment has comparable effects on disease parameters in both the normal weight and obese AS patients. Long-term treatment with anti-TNF drugs may lead to obesity. Prospective controlled studies with more patients to clarify this probable effect of anti-TNF drugs are required.
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    Diffuse Alveolar Hemorrhage: A Life-Threatening Complication of Systemic Lupus Erythematosus
    (CLINICAL & EXPER RHEUMATOLOGY, 2014) Cengiz, Ahmet Kivanc; Durmaz, Yunus; Dinler, Mustafa; Dogan, Sevil Ceyhan; Hayta, Emrullah; Akin, Recep; Gumus, Cesur; Kaptanoglu, Ece; Hizmetli, Sami
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    Hemodiyaliz hastalarında fibromiyalji sendromunun prevalansı ve yaşam kalitesine etkisi
    (Cumhuriyet Üniversitesi, 2017) Dinler, Mustafa; Doğan, Sevil Ceyhan
    Romatolojik hastalıklar, kronik böbrek hastalığı (KBH)'de görülen major komplikasyonlardan olmasına rağmen, KBH'li bireylerde Fibromiyalji Sendromu (FM)'nin sıklığını araştıran sınırlı sayıda çalışma vardır. Çalışmamızda Sivas il merkezinde hemodiyaliz tedavisi alan KBH'li hastalarda FM sıklığını ve FM'nin bu hastalarda yaşam kalitesine etkisini, ayrıca laboratuvar ve sosyodemografik parametrelerin FM sıklığına etkisini incelemeyi amaçladık. Çalışmaya, hemodiyaliz tedavisi alan KBH'li 248 (133 kadın, 115 erkek) hasta dahil edilmiştir. Hastalar, ACR 2010 FM tanı kriterlerine göre FM olan 33 bireyden oluşan hasta grubu ve FM olmayan 215 bireyden oluşan hasta grubu olarak ikiye ayrıldı. Hastaların yaşam kalitelerini değerlendirmek için Short Form-36 (SF-36) ve Kidney Disease Quality of Life-36 (KDQOL-36) kullanıldı. Ayrıca FM olan hastalarda fonksiyonel durumu ölçmek için Fibromiyalgia İmpact Questionnaire (FIQ) kullanıldı. Çalışmaya katılan KBH'li hastaların sosyodemografik [yaş, cinsiyet, eğitim durumu, vücut kitle indeksi (VKİ), diyaliz süresi] verileri ve laboratuvar parametrelerinden hemoglobin (Hgb), serum albumin, kreatinin, kan üre azotu (BUN), alkalen fosfataz (ALP), kalsiyum (Ca) x fosfat (P), paratiroid hormon (PTH) ve diyaliz yeterliliği göstergelerinden olan Kt/V'nin son 1 ay içerisindeki değerleri çalışma formuna kaydedildi. Çalışmaya katılan bireylerin 33'ünde (%13.3) FM saptandı. FM tanılı 33 hastanın hepsi kadındı. Erkek hastalarda FM yoktu. SF-36 ve KDQOL-36 tüm alt parametreleri yönünden karşılaştırıldığında FM olan grupta, FM olmayan gruba göre yaşam kalitesi anlamlı olarak daha düşüktü (p<0.05). Hastaların laboratuvar parametreleri (Hgb, serum albumin, kreatinin, BUN, ALP, CaxP, PTH), diyaliz süresi, Kt/V, medeni durum ve VKİ karşılaştırıldığında gruplar arasında anlamlı bir farklılık saptanmadı (p>0.05). Diğer yandan hemodiyaliz tedavisi alan hastalarda ileri yaş, kadın cinsiyet, sistemik hastalık ve/veya hepatit B ve C enfeksiyonu varlığında FM sıklığı anlamlı olarak daha fazlaydı (p<0.05). Ayrıca hemodiyaliz tedavisi alan hastalarda eğitim düzeyi azaldıkça FM sıklığı anlamlı bir şekilde artmaktaydı (p<0.05). Hemodiyaliz hastalarında yaşam kalitelerini önemli ölçüde azaltan FM, bu hastalarda normal popülasyona göre daha sık görülmektedir. Bu nedenle yaygın vücut ağrısıyla başvuran hemodiyaliz hastalarında FM'nin akılda tutulması, FM'nin erken tanı ve etkili tedavisiyle yaşam kalitesini iyileştirmek için hastalara ek yarar sağlayacaktır. Anahtar Kelimeler: Hemodiyaliz, Fibromiyalji Sendromu Prevalansı, Yaşam Kalitesi
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    PREVALENCE OF FIBROMYALGIA SYNDROME AND ITS EFFECT ON QUALITY OF LIFE IN HEMODIALYSIS PATIENTS
    (2021) Dinler, Mustafa; Doğan, Sevil Ceyhan; Kayataş, Mansur
    Objective: We evaluated the prevalence of fibromyalgia syndrome (FM) in hemodialysis patients and whether this syndrome was associated withgender, age, duration of hemodialysis, or other laboratory parameters.Methods: The study included 248 patients with chronic kidney disease (CKD) undergoing hemodialysis. The patients were stratified into twogroups: patients with FM based on the 2010 American College of Rheumatology diagnostic criteria and patients not meeting these criteria withoutFM. Quality of life (QOL) was assessed using the Short Form-36 (SF-36) and Kidney Disease Quality of Life-36 (KDQOL-36) questionnaires.Sociodemographic data, laboratory parameters and a marker for adequacy of hemodialysis (Kt/V) were recorded.Results: FM was detected in 33/248 (13.3%) of patients included. All patients diagnosed as FM were female. When all sub-parameters of SF-36 andKDQOL-36 were compared, QOL was lower in the FM group compared to patients without FM (p<0.05). When laboratory parameters, dialysisduration, Kt/V, marital status and BMI were compared, no difference was detected between groups (p>0.05). FM frequency was higher in cases ofadvanced age, presence of systemic disease and/or hepatitis B and C infection in patients undergoing hemodialysis (p<0.05). In addition, FMfrequency was inversely proportional to education level (p<0.05).Conclusion: FM, associated with a significant decrease in QOL, is more commonly seen in CKD patients undergoing dialysis compared to thegeneral population. Thus, it will be helpful to keep FM in mind and to improve QOL in these patients by early diagnosis and treatment.
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    Prevalence of Fibromyalgia Syndrome and its Effect on Quality of Life in Hemodialysis Patients
    (Kocaeli Üniversitesi, 2021) Doğan, Sevil Ceyhan; Dinler, Mustafa; Kayataş, Mansur
    Objective: We evaluated the prevalence of fibromyalgia syndrome (FM) in hemodialysis patients and whether this syndrome was associated with gender, age, duration of hemodialysis, or other laboratory parameters. Methods: The study included 248 patients with chronic kidney disease (CKD) undergoing hemodialysis. The patients were stratified into two groups: patients with FM based on the 2010 American College of Rheumatology diagnostic criteria and patients not meeting these criteria without FM. Quality of life (QOL) was assessed using the Short Form-36 (SF-36) and Kidney Disease Quality of Life-36 (KDQOL-36) questionnaires. Sociodemographic data, laboratory parameters and a marker for adequacy of hemodialysis (Kt/V) were recorded. Results: FM was detected in 33/248 (13.3%) of patients included. All patients diagnosed as FM were female. When all sub-parameters of SF-36 and KDQOL-36 were compared, QOL was lower in the FM group compared to patients without FM (p<0.05). When laboratory parameters, dialysis duration, Kt/V, marital status and BMI were compared, no difference was detected between groups (p>0.05). FM frequency was higher in cases of advanced age, presence of systemic disease and/or hepatitis B and C infection in patients undergoing hemodialysis (p<0.05). In addition, FM frequency was inversely proportional to education level (p<0.05). Conclusion: FM, associated with a significant decrease in QOL, is more commonly seen in CKD patients undergoing dialysis compared to the general population. Thus, it will be helpful to keep FM in mind and to improve QOL in these patients by early diagnosis and treatment.