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Öğe Apoptotic effects of topical antiglaucoma medications on conjunctival epithelium in glaucoma patients(SAGE PUBLICATIONS LTD, 2014) Arici, Mustafa Kemal; Arici, Dilek Sema; Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Erdogan, HaydarPurpose: In this study, we aimed to investigate the apoptotic effects of topical antiglaucoma medications on the conjunctival epithelium. Methods: A total of 65 patients were included in the study. Thirty patients were included in the first group who had received antiglaucomatous therapy before trabeculectomy. In the second group, 20 patients who had received no drugs before trabeculectomy were included, while the third group underwent only cataract surgery as control. During the surgery, 2 x 4 mm conjunctival samples were harvested from the upper bulbar conjunctiva. The mean apoptosis rate was calculated by determining apoptosis at conjunctival epithelium using the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) method. Results: The mean apoptosis rate was 0.537 +/- 0.369 (0.026 +/- 0.962) in group 1, 0.139 +/- 0.162 (0.005 +/- 0.676) in group 2, and 0.078 +/- 0.035 (0.035 +/- 0.142) in the control group (group 3). The mean apoptosis rate was significantly higher in the first group than the other 2 groups (p = 0.0001). Conclusions: Apoptotic effects of topical antiglaucoma drugs on the conjunctival epithelial cells were found. However, our results revealed that the number of medications, duration of medication, and type of glaucoma had no effect on the apoptotic effect.Öğe Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients(SPRINGER JAPAN KK, 2014) Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Demirci, Yuksel; Topalkara, Aysen; Erdogan, Haydar; Arici, Mustafa Kemal; Ersalcan, TanerPurpose To investigate levels of ghrelin in the aqueous humour (AqH) of patients with exfoliation syndrome and exfoliation glaucoma and compare them to levels of ghrelin in control subjects. Methods This cross-sectional study involved 15 patients with exfoliation syndrome, 8 with exfoliation glaucoma and 12 control subjects for whom cataract surgery was indicated. The AqH was aspirated from the anterior chamber with a 27-G needle under sterile conditions prior to tissue manipulation. Ghrelin levels were quantified using radioimmunassay kits. Results Levels of ghrelin in the AqH were 187.87 +/- 80.1 pg/mL in the eyes exhibiting exfoliation syndrome, 98.53 +/- 50.9 pg/mL in the eyes exhibiting exfoliation glaucoma and 111.40 +/- 77.5 pg/mL in the controls. Ghrelin level of patients with exfoliation syndrome were significantly higher than those of patients with exfoliation glaucoma and the controls (P<0.05). Ghrelin levels of patients with exfoliation glaucoma were lower than those of the controls but were not reach statistically significant (P>0.05). Age, gender and IOP did not have a significant effect on ghrelin levels in patients with exfoliation syndrome and exfoliation glaucoma. Conclusion This study is the first to report elevated levels of ghrelin in the AqH in eyes exhibiting exfoliation syndrome. Findings suggest ghrelin might play role in the etiopathogenesis of exfoliation syndrome to exfoliation glaucoma.Öğe The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor(HINDAWI PUBLISHING CORPORATION, 2014) Kirboga, Kadir; Ozec, Ayse V.; Kosker, Mustafa; Dursun, Ayhan; Toker, Mustafa I.; Aydin, Huseyin; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa K.Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P = 0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P = 0.004). Mean TOS levels in the serum were 2.93 +/- 0.19 in the DRP group and 2.61 +/- 0.26 in the control group (P = 0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.Öğe Association of neutrophil/lymphocyte ratio and retinal vein occlusion(WICHTIG PUBL, 2015) Dursun, Ayhan; Ozturk, Sultan; Yucel, Hasan; Ozec, Ayse Vural; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Topalkara, AysenPurpose: To evaluate the association between neutrophil/lymphocyte ratio (NLR) and the development of retinal vein occlusion (RVO). Methods: Forty patients were included in the study. Forty age- and sex-matched healthy volunteers were recruited as the control group. The RVO diagnosis was made clinically, based on the findings of fundus examination. The NLR and file records of the patients and the control group were compared. Results: The mean age of patients was 64 +/- 12 years. Neutrophil levels were higher in RVO patients compared to the control subjects (5.1 +/- 1.9 vs 3.6 +/- 1.0, p<0.001). Lymphocyte levels were lower in RVO patients compared with the control subjects (2.0 +/- 0.7 vs 2.6 +/- 0.9, p = 0.005). The NLR was significantly higher in RVO patients compared with the control subjects (3.0 +/- 2.7 vs 1.5 +/- 0.3, p<0.001). According to the receiver operator characteristics curve analysis, the optimal cutoff value of NLR to predict RVO was > 1.89, with 72.5% sensitivity and 100% specificity. Conclusions: The current study demonstrated that higher NLR was associated with the development of RVO. The NLR may be used as a predictive tool for identifying risk for RVO.Öğe Bilateral-14.0 diopters index myopia successfully treated with cataract surgery - A case report(HUMANA PRESS INC, 2006) Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Kal, Ali; Topalkara, Aysen; Arslan, Osman SevkiWe report a 60-year-old man with bilateral nuclear cataract and -14.0 diopters index myopia. Following uncomplicated phacoemulsifications and posterior chamber intraocular lens implantations on both eyes, right and left axial lengths were 22.58 and 22.60, mm with otobiomeric A-scan ultrasound, respectively. Three-month corrected visual acuity was 20/20 in the right eye with a -1.00 x 130 degrees cylinder and 20/20 in the left eye with -0.50 spheres and -1.00 x 100 degrees cylinders.Öğe Blefaropitozis Cerrahisinde Demografik ve Klinik Özelliklerin Değerlendirilmesi: Tek Merkez 10 Yıllık Sonuçlar(2021) Yeter, Duygu Yalınbaş; Bozali, Erman; Dursun, Demet; Ozec, Ayse Vural; Erdogan, HaydarAmaç: Blefaropitozis cerrahisinde klinik, demografik özellikler ve cerrahi yaklaşımı tek merkez, on yıllık veriler doğrultusunda değerlendirmek. Gereç ve Yöntem: Bu geriye dönük çalışmada, 2010-2020 tarihleri arasında blefaropitozis tanısı konup cerrahi geçiren hastaların dosyaları tarandı. Hastaların pitozis derecesi, preoperatif ve postoperatif levator fonksiyonu, marjin refle mesafesi, vertikal kapak aralığı ve cilt kıvrımı ölçümleri, yapılan cerrahiler, komplikasyonlar, takip süreleri ve cerrahi başarı oranları kaydedildi. Bulgular: Çalışmaya 72’si erkek, 51’i kadın olmak üzere 123 hastanın 153 gözü dahil edildi. Hastaların 51’inde (%41) kazanılmış pitozis, 72’sinde (%59) konjenital pitozis mevcuttu. Kazanılmış pitozis grubunda 5’i travmatik olmak üzere hepsi aponörotik pitozisti. Konjenital pitozis grubunda ise Marcus Gunn fenomeni olan bir hasta dışında hepsi basit konjenital pitozisti. Kazanılmış pitozis grubunda en sık uygulanan cerrahiler levator aponöroz onarımı (%59) ve levator rezeksiyonu (%41), konjenital pitozis grubunda is levator rezeksiyonu (%57) ve frontal askı (%42) cerrahisiydi. En yüksek başarı oranları hem konjenital hem de kazanılmış pitozis grubunda levator rezeksiyonu cerrahisinde izlendi (sırasıyla %85 ve %82). Sonuç: Blefaropitozis cerrahisinde başarılı bir cerrahi sonuç için doğru cerrahi planlama en önemli basamaktır. Levator fonksiyonu kötü olmayan gözlerde tercih edilen levator rezeksiyonu cerrahisi hem kazanılmış pitozis hem de konjenital pitozis grubunda en başarılı yöntemdir.Öğe Central corneal thickness and Diaton transpalpebral tonometry(SPRINGER, 2008) Toker, Mustafa Ilker; Vural, Ayse; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa KemalBackground To examine the effects of central corneal thickness on the measures obtained from transpalpebral tonometry (Diaton), and to identify correlations between intraocular pressure (IOP) measurements with Diaton and the Goldmann applanation tonometer (GAT). Methods In this cross-sectional study, 162 eyes of 81 participants were included. Intraocular pressure measurements were obtained in all patients using Diaton and GAT. Central corneal thickness was determined by ultrasound pachymetry. The participants were stratified by corneal thickness: group I < 530 mu m (n=56), group II 530-560 mu m (n=65), and group III > 560 mu m (n=41). Results There were moderate correlations between IOP readings obtained using the Diaton and corrected GAT (C-GAT) (r=0.303; P < 0.0001), and between corrected Diaton (C-Diaton), and C-GAT (r=0.399; P0.0001). The mean Diaton tonometer readings were lower than C-GAT measurements (Diaton-corrected GAT mean difference, 0.9 +/- 3.8 mmHg; c-Diaton-corrected GAT mean difference, 0.7 +/- 3.5 mmHg). Differences were detected between the groups of patients for the GAT values [2.4 +/- 3.6 mmHg for those with the thinnest corneas (< 530 mu m), 0.7 +/- 3.6 mmHg for those with moderate corneas (between 531 mu m and 560 mu m), and -0.6 +/- 3.6 mmHg for those with the thickest (> 560 mu m) corneas], whereas a significantly lower difference (0.9 +/- 3.8 mmHg) was noted for the Diaton values of all individuals. Conclusions The Diaton measurements show moderate correlation with those provided by applanation tonometry. The Diaton tonometer seems to be more affected by the corneal thickness, especially in the thinnest corneas.Öğe Comparison of Outcomes of External Dacryocystorhinostomy and Transcanalicular Laser-Assisted Dacryocystorhinostomy in Patients with Primary Acquired Nasolacrimal Duct Obstruction(Georg Thieme Verlag Kg, 2022) Mutlu, Demet; Bayram, Nurettin; Arici, Mustafa Kemal; Ozec, Ayse Vural; Erdogan, Haydar; Toker, Mustafa IlkerPurpose This study aimed to compare anatomical and functional outcomes of external dacryocystorhinostomy (EX-DCR) and transcanalicular multidiode laser dacryocystorhinostomy (TDL-DCR) in patients with primary acquired nasolacrimal duct obstruction (PANDO). Methods This study was conducted on 60 eyes of 60 patients with PANDO. The study subjects were randomly divided into two groups. Group 1 included 30 patients who underwent EX-DCR, and group 2 included 30 patients who underwent TDL-DCR. Surgery success rates were determined by patency of the neo-ostium, with free saline flow on irrigation and the absence of epiphora. Results There were 23 women (76.7%) and 7 men (23.3%) with a mean age of 47.33 +/- 12.44 years in group 1, and 18 women (60%) and 12 men (40%) with a mean age of 46.2 +/- 19.4 years in group 2. There was no significant difference between groups 1 and 2 with respect to age or gender (p = 0.801, p = 0.267, respectively). The mean duration of symptoms was 3.2 years, ranging from 1.5 to 5 years. The mean postoperative follow-up was 12.3 +/- 2.44 months. At the end of the follow-up period, the surgery success rates were 96.7% (29/30 eyes) in group 1, and 90% (27/30 eyes) in group 2. There was no statistical difference in the surgery success rates between groups (p = 0.612). Conclusion TDL-DCR is a minimally invasive and safe procedure. The lack of bleeding and incision scar and shorter operation time suggest that TDL-DCR can be a good alternative in PANDO patients.Öğe Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model(IJO PRESS, 2012) Dursun, Ayhan; Arici, Mustafa Kemal; Dursun, Feyza; Ozec, Ayse Vural; Toker, Mustafa Ilker; Erdogan, Haydar; Topalkara, AysenAIM: To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali bum-induced model of corneal angiogenesis. METHODS: Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. RESULTS: The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P<0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. CONCLUSION: Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization.Öğe Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery(IJO PRESS, 2011) Erdogan, Haydar; Ozec, Ayse Vural; Caner, Cengiz; Toker, Mustafa Ilker; Arici, Mustafa Kemal; Topalkara, AysenAIM: To evalaute the effect of fixed-combination latanoprost 0.005% /timolol maleate 0.5% and dorzolamide hydrochloride 2% /timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery. METHODS: This study is a prospective, randomized, double-masked and placebo-controlled. The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery. Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients). Two hour before surgery, the patients received one drop latanoprost/timolol (group 1), dorzolamide/timolol (group 2) and placebo (group 3, control group). The IOPs were measured at preoperative and postoperative 4, 8, and 24 hours. RESULTS: The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group. In group 1 and 2, the postoperative mean TOP [group1: (14.03 +/- 3.15)mmHg and group 2: (14.16 +/- 4.43) mmHg] at 24 hours were significantly lower than the control group [(16.93 +/- 3.70)mmHg, (P < 0.05)]. In addition, the postoperative mean IOP of group 1 [(14.90? .69)mmHg] at 8 hours was significantly lower than the control group [(17.70 +/- 3.89)mmHg, (P < 0.05)], but there was no significant difference between group 2 [(16.16 +/- 5.23)mmHg] and control group at 8 hours (P > 0.05). CONCLUSION: When compared with placebo, the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery, but did not completely prevent TOP spikes.Öğe The effect of propolis in experimental Acanthamoeba keratitis(WILEY, 2007) Vural, Ayse; Polat, Zubeyde Akin; Topalkara, Aysen; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Cetin, AliPurpose: To examine the effect of propolis in a rat model of Acanthamoeba keratitis and to determine its in vitro cytotoxicity in cultured corneal epithelial cells. Methods: Eighteen Wistar albino rats were used. Cultured corneal epithelial cells obtained from two healthy rats for in vitro cytotoxicity of propolis. Corneal stromal inoculation was performed in 16 rats with amoebic culture containing 1 x 10(6) amoeba/mL. Rats with Acanthamoeba keratitis 5 days later after the inoculation were divided randomly into four groups, and eight eyes of each group were treated with study drugs. The propolis, chlorhexidine (CHX), propolis plus CHX and control eyes were treated with topical propolis, 0.002% CHX, propolis plus 0.002% CHX and lubricant eye drops, respectively. The study drugs were instilled every one hour for 10 days. All eyes were examined and keratitis graded by slit-lamp biomicroscopy on days 2, 5 and 10 during the administration of the study drugs. After the completion of keratitis grading, all the 16 rats were humanely killed and their corneas were excised and used for Acanthamoeba culture to evaluate presence of Acanthamoeba growth after treatment 14 days later. Results: Concentrations of propolis higher than 7.81 mg/mL cause damage to corneal epithelial cells in the experiment of in vitro cytotoxicity of propolis on corneal epithelial cells. The keratitis grade on day 2 in the CHX eyes was significantly lower than that in the control eyes (P < 0.05). The keratitis grades on days 5 and 10 in the propolis, CHX and propolis plus CHX eyes were significantly lower compared with those on days 5 and 10 in the control eyes (P < 0.05). In the propolis eyes, the keratitis grade on day 5 was significantly lower than that on day 2 (P < 0.05), and it was significantly lower on day 10 compared with that on day 5 (P < 0.05). In the CHX and propolis plus CHX eyes, the keratitis grade on day 10 was significantly lower compared with that on days 2 and 5 (P < 0.05). In the control eyes, there was no significant difference in the keratitis grades on days 2, 5 and 10 (P > 0.05). The culture positivity at Acanthamoeba growth after treatment experiment in the propolis, CHX and propolis plus CHX eyes was significantly lower than that in the control eyes (P < 0.05). Conclusions: We suggest that propolis had amoebicidal properties in this rat model of Acanthamoeba keratitis. Further investigations to evaluate the antimicrobial activity of the individual fractions of the resin could yield more information about its mechanism of action in treating this disease.Öğe The effects of different doses of remifentanil on intraocular pressure after tracheal intubation: A randomized, double-blind and prospective study(AMER SOC CONTEMPORARY MEDICINE SURGERY & OPHTHALMOLOGY, 2007) Kaygusuz, Kenan; Toker, M. Ilker; Kol, Iclal Ozdemir; Erdogan, Haydar; Gursoy, Sinan; Mimaroglu, CanerWe investigated the effects of alfentanil and different doses of remifentanil on intraocular pressure (IOP) and hemodynamic responses during laryngoscopy and endotracheal intubation in 60 patients. IOP values decreased significantly from 30 seconds before the intubation to 5 minutes after intubation measurements compared to baseline values in all the groups. However, a significant increase in 1OP was recorded in the 0.5-mu g remifentanil group after tracheal intubation.Öğe Efficacy of First Turkish Made Single-Piece Foldable Hydrophobic Acrylic Intraocular Lens Zaraccom F260 on Cataract Treatment(AMER SOC CONTEMPORARY MEDICINE SURGERY & OPHTHALMOLOGY, 2008) Toker, Mustafa Ilker; Vural, Ayse; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa KemalWe evaluated the efficacy of Zaraccom F260 intraocular lenses (IOL) on cataract treatment in 97 adult cataract patients (114 eyes) who underwent phacoemulsification and IOL implantation. The mean preoperative best-corrected visual acuity (BCVA) was 0.26 +/- 0.26 at one week 0.49 +/- 0.25 and 0.9 +/- 0.28 at follow-ups. The Zaraccom F260 is an alternative for the patients requiring lens replacement.Öğe Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma(HINDAWI PUBLISHING CORP, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Dogan, Oznur; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Topalkara, Aysen; Arici, Mustafa Kemal; Erdogan, HaydarPurpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in the macular and peripapillary areas were measured by using spectral domain optical coherence tomography. Results. Gender, age, and axial length did not significantly differ between the groups (all, p > 0.05). The mean values of choroidal thickness in the macular and peripapillary areas (except the superior quadrant) in the patients with PEX syndrome and PEX glaucoma were lower compared with controls (all p < 0.05). The mean values of the macular and peripapillary choroidal thickness in the PEX glaucoma group were lower compared with PEX syndrome group; however this difference was not significant. Conclusions. The findings of this study revealed that macular and peripapillary choroidal thicknesses were decreased in PEX syndrome and PEX glaucoma cases. The role of choroid in the development of glaucomatous damage in patients with PEX syndrome remains unclear.Öğe Evaluation of Foveal Thickness and Macular Choroidal Thickness with Optical Coherence Tomography in Behcet's Disease(Marmara Univ, Inst Health Sciences, 2021) Bozali, Erman; Erdogan, Haydar; Dursun, Ayhan; Ozec, Ayse Vural; Toker, Mustafa Ilker; Arici, Mustafa KemalObjective: To evaluate the foveal thickness and macular choroidal thickness on patients who were diagnosed with Behcet's Disease (BD). Methods: A total of 60 patients were included in this prospective cross-sectional study. Patients were divided into two groups. Group 1 consisted of 30 patients who were diagnosed with BD and Group 2 consisted of 30 healthy controls. Detailed ophthalmological examination was performed on both groups and foveal thickness and macular choroidal thickness were measured with Spectral-Domain Optical Coherence Tomography (SD-OCT). To measure the choroidal thickness enhanced depth imaging OCT (EDI-OCT) technique was used. Results: Mean foveal thickness in BD patients was 216.06 +/- 53.14 mu m and mean subfoveal choroidal thickness was 363.21 +/- 85.22 mu m. Mean foveal thickness and subfoveal choroidal thickness in healthy controls was 211.65 +/- 16.60 mu m and 352.83 +/- 87.11 mu m respectively. There was no statistical significance between patients with BD and patients of the control group regarding foveal and subfoveal choroidal thickness. However, anatomical deformation of Ellipsoid Zone structure in OCT had the most effect on visual acuity (p=0.001). Conclusion: This study shows that there was no statistically significant difference in terms of foveal thickness and macular choroidal thickness in patients with BD.Öğe Evaluation of inner and outer retinal thickness in patients receiving intravitreal ranibizumab injections for diabetic macular edema(SAGE PUBLICATIONS LTD, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Kirboga, Kadir; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa KemalPurpose: To measure inner and outer retinal thickness with optical coherence tomography (OCT) in patients in whom intravitreal ranibizumab was administered due to diabetic macular edema (DME) and to investigate its relation to the visual prognosis. Methods: In this retrospective case series, there were 60 consecutive eyes with DME in which intravitreal ranibizumab injection was performed for 3 times in 1-month intervals. All patients underwent full ophthalmic examination and spectral-domain OCT (SD-OCT). The total retinal thickness, the inner thickness, and the outer thickness in 4 parafoveal subfields were measured. The correlation between the retinal thickness and logMAR best-corrected visual acuity (BCVA) was investigated. Results: No significant correlation was found between the total retinal thickness in the central and other subfields and either the baseline or final visit logMAR BCVA values (p>0.05). There was a significant positive correlation between the final visit logMAR BCVA values and pretreatment inner retinal thickness in the nasal and inferior subfields (r = 0.270, p = 0.037, and r = 0.410, p = 0.001, respectively). There was significant negative correlation between the final visit logMAR BCVA values and pretreatment outer retinal thickness in nasal and temporal parafoveal subfields (r = -0.297, p = 0.021, and r = -0.268, p = 0.038, respectively). Conclusions: It could be beneficial to use inner and outer retinal thickness instead of total retinal thickness in determination of short-term prognosis in patients who had intravitreal ranibizumab injection for DME.Öğe Evaluation of Serum Homocysteine and Leptin Levels in Patients with Uveitis(TURKISH OPHTHALMOLOGICAL SOC, 2015) Elbay, Arif Emre; Topalkara, Aysen; Elbay, Ahmet; Erdogan, Haydar; Vural, Ayse; Cetin, Abdi BahadirObjectives: To evaluate the serum homocysteine (Hcy) and leptin levels in patients with uveitis. Materials and Methods: The 70 cases included in the study comprised 3 groups: patients with Behcet's uveitis (BU), patients with non-Behcet's uveitis (NBU) and healthy controls. Body mass index was calculated for each subject. Serum Hcy and leptin levels were measured. Furthermore, acute-phase reactants including erythrocyte sedimentation rate (ESR), C-reactive protein and neutrophil count were measured. Results: Serum Hcy levels were 15.04 +/- 4.59 mu mol/L in the BU group, 15.4 +/- 6.87 mu mol/L in the NBU group and 13.64 +/- 4.72 mu mol/L in the control group (p>0.05). The serum leptin levels of male patients in the BU group, NBU group and control group were 4.76 +/- 3.54 ng/ml, 6.33 +/- 3.74 ng/ml and 5.47 +/- 6.33 ng/ml, respectively (p>0.05). When we compared serum leptin levels in female patients and controls, the mean serum leptin concentrations were significantly higher in female BU and NBU patients (24.83 +/- 17.62 ng/ml and 28.46 +/- 13.90 ng/ml, respectively) than in healthy control volunteers (9.62 +/- 6.36 ng/ml, p<0.05). In addition, the ESR value differences between groups were statistically significant (p<0.05). Conclusion: A larger case series is necessary to investigate serum Hcy and leptin concentrations in uveitis patients.Öğe Expression levels of some genes in the MAPK pathway (DUSP1, DUSP2, DUSP4, DUSP6 and DUSP10) in eyelid tumor tissue(Walter De Gruyter Gmbh, 2024) Ozmen, Esma; Tas, Ayca; Akin, Dilara Fatma; Erdogan, Haydar; Silig, YavuzObjectives To control mitogen-activated protein kinases (MAPK) signaling pathways involved in the onset and progression of cancer, dual specificity phosphatases (DUSPs/MKP) are essential. This study seeks to detect the correlation between eyelid tumors and the genes DUSPs, known for their influence on MAPK signaling pathways. Additionally, we aim to juxtapose our findings with analyses from various bioinformatics databases.Methods Expression levels of relevant genes in cDNA samples were determined by quantitative PCR method. Open-access databases were used for mutation analysis of relevant genes, mRNA expression changes, and survival analyses, and the STRING database was used for protein-protein interactions.Results It was found that the expression of DUSP1 and DUSP2 showed a significant decrease in the tumor tissue, while a significant increase was detected in the DUSP4 and DUSP6 genes. Additionally, when we compared the study genes with the Cancer Genome Atlas program cancer cohorts, it was found that the DUSP1 and DUSP10 gene expression profiles were downregulated in uveal melanoma compared to other cancer cohorts.Conclusions Significant and obvious changes were observed in the DUSP genes we studied in eyelid tumors. However, the relationship between these genes and cancer must be studied more. Considering that these enzymes are effective in cell proliferation, differentiation, and apoptosis, it would be appropriate to plan comprehensive studies on their interactions with other proteins they interact with in the MAPK pathway.Öğe Intracorneal implantation of a misdirected foldable intraocular lens during phacoemulsification surgery: a case report(Consel Brasil Oftalmologia, 2024) Toker, Mustafa Ilker; Bozali, Erman; Unal, Mustafa; Ozec, Ayse Vural; Erdogan, Haydar| A 59-year-old man presented with a unilateral blurring of vision in his left eye. His left eye's visual acuity was hand movements level. He underwent phacoemulsification surgery, and an intrastromal posterior chamber intraocular lens was implanted. The intrastromal intraocular lens was extracted and a new intraocular lens was implanted. Usinge the Snellen chart, the final best-corrected visual acuity was 20/40. With this case report, we wish to emphasize that a single stepwise clear corneal incision merged with wound-assisted intraocular lens injections can result in intraocular lens misdirection into the corneal stroma. As a result, while performing a misdirected intraocular lens removal, we recommend that the wound be carefully constructed.Öğe Ocular Findings in Patients with Crimean-Congo Hemorrhagic Fever(ELSEVIER SCIENCE INC, 2009) Engin, Aynur; Erdogan, Haydar; Ozec, Ayse Vural; Elaldi, Nazif; Toker, Mustafa Ilker; Bakir, Mehmet; Dokmetas, Ilyas; Arici, Mustafa KemalPURPOSE: To describe ocular findings of patients with Crimean-Congo hemorrhagic fever (CCHF). DESIGN: Prospective, interventional, consecutive case series. METHODS: This study was conducted in Sivas, a city located in the central Anatolia, between July 1 and August 31, 2007. Confirmed CCHF patients were enrolled in the study and underwent ocular examination during hospitalization. RESULTS: Nineteen confirmed CCHF patients were included in this study. All patients were classified into 2 groups in terms of disease severity (severe vs nonsevere), according to the Swanepoel predictive criteria. Fourteen patients (73.7%) were classified as "nonsevere," and the remaining 5 patients (26.3%) were classified as "severe" in this study. One patient having severe disease died. Ocular findings were present in 14 patients (73.7%) and none of the patients presented any visual complaints. Ocular examination revealed that 7 patients (36.8%) had only bilateral multiple subconjunctival hemorrhage, and 2 patients (10.5%) (1 bilateral, I unilateral) had retinal hemorrhage. Five patients (26.3%) had subconjunctival hemorrhage and retinal hemorrhage. Follow-up examination 1 month later showed complete resorption of the subconjunctival hemorrhage and retinal hemorrhage. There was a statistically significant difference between patients with ocular findings and patients without ocular findings for prothrombin time (P = .011). There was no evidence of uveitis, retinal edema, sheathing of retinal vessels, or intravitreal hemorrhage in our patients. CONCLUSION: From the small sample study, CCHF caused a mild form of ocular disease. CCHF must be considered when subconjunctival or superficial retinal hemorrhages are seen in association with fever in endemic areas. (Am J Ophthalmol 2009;147:634-638. (C) 2009 by Elsevier Inc. All rights reserved.)
