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Öğe Multifunctional Magnetic Nanoparticles in Hyperthermia Therapy(CRC Press, 2024) Rbaa, Mohamed; Hichar, Abdelhadi; Oubaaqa, Mohamed; Seghiri, Rajaa; Berdimurodov, Elyor; Tüzün, Burak; Zarrouk, AbdelkaderAn overview of the writing on the application of multifunctional magnetic nanoparticles (MF-MNP) in hyperthermia treatment is given in this chapter. With their special attractive characteristics, these MF-MNP can be utilized to target and wipeout warm tissues. These magnetic nanoparticles with numerous capacities can also cause hyperthermia. They have an assortment of capacities that permit them to be utilized in a wide range of settings, such as demonstrative imaging and applications like destroying cancer cells. MF-MNP has incredible possibilities for progressing the treatment of infection. © 2025 selection and editorial matter, Edited by Elyor Berdimurodov, Chaudhery Mustansar Hussain, and Burak Tüzün; individual chapters, the contributors.Öğe Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and ADME/T studies(Elsevier, 2021) Rbaa, Mohamed; Oubihi, Asmaa; Hajji, Halima; Tuzun, Burak; Hichar, Abdelhadi; Anouar, El Hassane; Berdimurodov, ElyorY The present study aims to first explore the relationship between the chemical structure of the organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities, as well as the impact of substituent effects on their antibacterial properties. These compounds were synthesized by efficient methods, and their structures confirmed by the spectral methods (IR, H-1 NMR, C-13 NMR and elemental analysis). The antibacterial activities of synthesized the compounds were checked with five Gram-positive and Gram-negative strains such as Enterobacter cloacae (ATCC29893),Escherichia coli (ATCC35218), Klebsiella pneumoniae (ATCC13883), Staphylococcus aureus (ATCC29213) and Acinetobacter baumannii (ATCC19606). The results of the antibacterial activities of four synthesized compounds were compared with three standard antibiotics [Penicillin G, Erythromycin and Norfloxacin (quinoline type)]. The minimum inhibitory concentrations (MICs) of active compounds were calculated and discussed. The chemical and biological activities of hydroxyquinoline derivatives were compared with theoretical methods. The chemical activities of hydroxyquinoline derivatives were contrasted with the important quantum chemical parameters using the HF/6-31++ g (d, p) basis sets. Besides, biological activities of hydroxyquinoline derivatives against cancer proteins that are respectively protein of the BRCT repeat region of breast cancer that is ID: 1JNX, crystal structure of liver cancer protein that is ID: 3WZE, and crystal structure of lung cancer protein that is ID: 5ZMA, were compared. ADME/T (Adsorption, Distribution, Metabolism, Excretion, and Toxicity) analysis was studied for molecules with high biological activity to become efficient drugs in the future. (C) 2021 Elsevier B.V. All rights reserved.Öğe Synthesis, characterization and bioactivity of novel 8-hydroxyquinoline derivatives: Experimental, molecular docking, DFT and POM analyses(Elsevier, 2022) Rbaa, Mohamed; Haida, Sara; Tuzun, Burak; Hichar, Abdelhadi; El Hassane, Anouar; Kribii, Abderahim; Lakhrissi, YounesIn this present research work, new 8-hydroxyquinoline derivatives were synthesized and their molecular structures were confirmed by the H-1 NMR, C-13 NMR, IR and elemental analysis. The antioxidant activity of the synthesized compounds is evaluated through their capacity to scavenge 2,2-di-phenyl-1picrylhydrazyl (DPPH) free radicals. In addition, their antibacterial activity was examined against bacterial strains of S. aureus, K. pneumonia, and E. coli. The obtained results showed that the antibacterial activity of studied compounds for Gram-positive and Gram-negative is higher than Penicillin G. The theoretical properties of selected compounds was computed by the DFT method. POM analysis (Petra/Osiris/Molinspiration) of studied molecules has been done. Their biological activities were compared against breast, liver and lung cancer proteins. The obtained results showed the synthesized derivatives were effective antibacterial and antioxidant agents against various biological material. (c) 2022 Elsevier B.V. All rights reserved.Öğe Synthesis, structural confirmation, antibacterial properties and bio-informatics computational analyses of new pyrrole based on 8-hydroxyquinoline(Elsevier, 2022) Lakhrissi, Younes; Rbaa, Mohamed; Tuzun, Burak; Hichar, Abdelhadi; Anouar, El Hassane; Ounine, Khadija; Almalki, FaisalThis study aims to synthesize new pyrrolic compounds derivatives of 8-hydroxyquinoline, explore the structure-activity relationship and the effect of the substituents carried by the pyrrole ring on their antibacterial properties. These compounds were characterized by IR, H-1, C-13 NMR and elemental analysis. The NMR predicted chemical shifts were determined by the GIAO approach and the solvent effect was taken into account using the polarizable continuum model (PCM). The evaluation of the antibacterial activity was carried out in vitro against three bacterial strains namely; E. coli (ATCC35218), S. aureus (ATCC29213) and P. aeruginosa (ATCC27853) using the disk method. The results of antibacterial activity were compared with those of a standard antibiotic (Norfloxacin). The Minimum Inhibitory Concentrations (MICs) were calculated and discussed. The results of the experimental tests were supported by bioinformatics Docking, DFT and POM studies. (C) 2022 Elsevier B.V. All rights reserved.Öğe Synthesis, Structural confirmation, Antibacterial Properties and Bio-Informatics Computational Analyses of New Pyrrole Based on 8-Hydroxyquinoline (vol 1259, 132683, 2022)(Elsevier, 2023) Lakhrissi, Younes; Rbaa, Mohamed; Tuzun, Burak; Hichar, Abdelhadi; Anouar, El Hassane; Ounine, Khadija; Almalki, Faisal[Abstract Not Available]
