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Apoptotic effects of topical antiglaucoma medications on conjunctival epithelium in glaucoma patients
(SAGE PUBLICATIONS LTD, 2014) Arici, Mustafa Kemal; Arici, Dilek Sema; Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Erdogan, Haydar
Purpose: In this study, we aimed to investigate the apoptotic effects of topical antiglaucoma medications on the conjunctival epithelium. Methods: A total of 65 patients were included in the study. Thirty patients were included in the first group who had received antiglaucomatous therapy before trabeculectomy. In the second group, 20 patients who had received no drugs before trabeculectomy were included, while the third group underwent only cataract surgery as control. During the surgery, 2 x 4 mm conjunctival samples were harvested from the upper bulbar conjunctiva. The mean apoptosis rate was calculated by determining apoptosis at conjunctival epithelium using the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) method. Results: The mean apoptosis rate was 0.537 +/- 0.369 (0.026 +/- 0.962) in group 1, 0.139 +/- 0.162 (0.005 +/- 0.676) in group 2, and 0.078 +/- 0.035 (0.035 +/- 0.142) in the control group (group 3). The mean apoptosis rate was significantly higher in the first group than the other 2 groups (p = 0.0001). Conclusions: Apoptotic effects of topical antiglaucoma drugs on the conjunctival epithelial cells were found. However, our results revealed that the number of medications, duration of medication, and type of glaucoma had no effect on the apoptotic effect.
Application of Topical/Subconjunctival Bevacizumab and Topical Fluorometholone Acetate in Alkali Burn-induced Model of Corneal Angiogenesis
(Turkish Ophthalmological Soc, 2010) Dursun, Ayhan; Arici, Mustafa Kemal; Ozec, Ayse Vural; Dursun, Feyza; Toker, Mustafa Ilker; Topalkara, Aysen
Purpose: To investigate the effect of bevacizumab on corneal neovascularization in an alkali burn -induced model of corneal angiogenesis. Material and Method: Twenty-four Wistar albino rats were used in our study. After chemical cauterization of the cornea, the rats were divided randomly into four groups. Group 1 (control group) received artificial tears twice a day, group 2 received topical fluorometholone acetate twice a day, in group 3, a single dose of bevacizumab (2.5 mg) was administered by a subconjunctival injection, and group 4 received topical bevacizumab 5mg/ml twice a day. Three weeks later, the rat corneas were evaluated by slit-lamp biomicroscopy and corneal photographs were taken with a digital camera, followed by sacrifice of the subjects. The proportional area of vascularized cornea, length of the longest neovascular sprout, corneal oedema and corneal opacity score were assessed. Result: The analysis of digital photographs showed less corneal neovascularization, corneal oedema, corneal opacity score and shorter length of the longest neovascular sprout in the three drug groups than in the control one (p<0.05). The area of corneal neovascularization in groups 3 and 4 was less than in group 2 (p=0.035 and p=0.027, respectively). Corneal neovascularization, corneal oedema and corneal opacity did not differ significantly between the subconjunctival and topical bevacizumab groups. However, statistically significant decrease was observed in the length of the longest neovascular sprout in the topical bevacizumab group (p=0.029). Discussion: Subconjunctival/topical bevacizumab treatment is an effective method in reducing corneal neovascularization. However, we observed that topical bevadzumab is more efficient than subconjunctival bevacizumab and fluorometholone acetate in preventing corneal neovascularization.
Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients
(SPRINGER JAPAN KK, 2014) Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Demirci, Yuksel; Topalkara, Aysen; Erdogan, Haydar; Arici, Mustafa Kemal; Ersalcan, Taner
Purpose To investigate levels of ghrelin in the aqueous humour (AqH) of patients with exfoliation syndrome and exfoliation glaucoma and compare them to levels of ghrelin in control subjects. Methods This cross-sectional study involved 15 patients with exfoliation syndrome, 8 with exfoliation glaucoma and 12 control subjects for whom cataract surgery was indicated. The AqH was aspirated from the anterior chamber with a 27-G needle under sterile conditions prior to tissue manipulation. Ghrelin levels were quantified using radioimmunassay kits. Results Levels of ghrelin in the AqH were 187.87 +/- 80.1 pg/mL in the eyes exhibiting exfoliation syndrome, 98.53 +/- 50.9 pg/mL in the eyes exhibiting exfoliation glaucoma and 111.40 +/- 77.5 pg/mL in the controls. Ghrelin level of patients with exfoliation syndrome were significantly higher than those of patients with exfoliation glaucoma and the controls (P<0.05). Ghrelin levels of patients with exfoliation glaucoma were lower than those of the controls but were not reach statistically significant (P>0.05). Age, gender and IOP did not have a significant effect on ghrelin levels in patients with exfoliation syndrome and exfoliation glaucoma. Conclusion This study is the first to report elevated levels of ghrelin in the AqH in eyes exhibiting exfoliation syndrome. Findings suggest ghrelin might play role in the etiopathogenesis of exfoliation syndrome to exfoliation glaucoma.
Association of neutrophil/lymphocyte ratio and retinal vein occlusion
(WICHTIG PUBL, 2015) Dursun, Ayhan; Ozturk, Sultan; Yucel, Hasan; Ozec, Ayse Vural; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Topalkara, Aysen
Purpose: To evaluate the association between neutrophil/lymphocyte ratio (NLR) and the development of retinal vein occlusion (RVO). Methods: Forty patients were included in the study. Forty age- and sex-matched healthy volunteers were recruited as the control group. The RVO diagnosis was made clinically, based on the findings of fundus examination. The NLR and file records of the patients and the control group were compared. Results: The mean age of patients was 64 +/- 12 years. Neutrophil levels were higher in RVO patients compared to the control subjects (5.1 +/- 1.9 vs 3.6 +/- 1.0, p<0.001). Lymphocyte levels were lower in RVO patients compared with the control subjects (2.0 +/- 0.7 vs 2.6 +/- 0.9, p = 0.005). The NLR was significantly higher in RVO patients compared with the control subjects (3.0 +/- 2.7 vs 1.5 +/- 0.3, p<0.001). According to the receiver operator characteristics curve analysis, the optimal cutoff value of NLR to predict RVO was > 1.89, with 72.5% sensitivity and 100% specificity. Conclusions: The current study demonstrated that higher NLR was associated with the development of RVO. The NLR may be used as a predictive tool for identifying risk for RVO.
Blefaropitozis Cerrahisinde Demografik ve Klinik Özelliklerin Değerlendirilmesi: Tek Merkez 10 Yıllık Sonuçlar
(2021) Yeter, Duygu Yalınbaş; Bozali, Erman; Dursun, Demet; Ozec, Ayse Vural; Erdogan, Haydar
Amaç: Blefaropitozis cerrahisinde klinik, demografik özellikler ve cerrahi yaklaşımı tek merkez, on yıllık veriler doğrultusunda değerlendirmek. Gereç ve Yöntem: Bu geriye dönük çalışmada, 2010-2020 tarihleri arasında blefaropitozis tanısı konup cerrahi geçiren hastaların dosyaları tarandı. Hastaların pitozis derecesi, preoperatif ve postoperatif levator fonksiyonu, marjin refle mesafesi, vertikal kapak aralığı ve cilt kıvrımı ölçümleri, yapılan cerrahiler, komplikasyonlar, takip süreleri ve cerrahi başarı oranları kaydedildi. Bulgular: Çalışmaya 72’si erkek, 51’i kadın olmak üzere 123 hastanın 153 gözü dahil edildi. Hastaların 51’inde (%41) kazanılmış pitozis, 72’sinde (%59) konjenital pitozis mevcuttu. Kazanılmış pitozis grubunda 5’i travmatik olmak üzere hepsi aponörotik pitozisti. Konjenital pitozis grubunda ise Marcus Gunn fenomeni olan bir hasta dışında hepsi basit konjenital pitozisti. Kazanılmış pitozis grubunda en sık uygulanan cerrahiler levator aponöroz onarımı (%59) ve levator rezeksiyonu (%41), konjenital pitozis grubunda is levator rezeksiyonu (%57) ve frontal askı (%42) cerrahisiydi. En yüksek başarı oranları hem konjenital hem de kazanılmış pitozis grubunda levator rezeksiyonu cerrahisinde izlendi (sırasıyla %85 ve %82). Sonuç: Blefaropitozis cerrahisinde başarılı bir cerrahi sonuç için doğru cerrahi planlama en önemli basamaktır. Levator fonksiyonu kötü olmayan gözlerde tercih edilen levator rezeksiyonu cerrahisi hem kazanılmış pitozis hem de konjenital pitozis grubunda en başarılı yöntemdir.
Comparison of Outcomes of External Dacryocystorhinostomy and Transcanalicular Laser-Assisted Dacryocystorhinostomy in Patients with Primary Acquired Nasolacrimal Duct Obstruction
(Georg Thieme Verlag Kg, 2022) Mutlu, Demet; Bayram, Nurettin; Arici, Mustafa Kemal; Ozec, Ayse Vural; Erdogan, Haydar; Toker, Mustafa Ilker
Purpose This study aimed to compare anatomical and functional outcomes of external dacryocystorhinostomy (EX-DCR) and transcanalicular multidiode laser dacryocystorhinostomy (TDL-DCR) in patients with primary acquired nasolacrimal duct obstruction (PANDO). Methods This study was conducted on 60 eyes of 60 patients with PANDO. The study subjects were randomly divided into two groups. Group 1 included 30 patients who underwent EX-DCR, and group 2 included 30 patients who underwent TDL-DCR. Surgery success rates were determined by patency of the neo-ostium, with free saline flow on irrigation and the absence of epiphora. Results There were 23 women (76.7%) and 7 men (23.3%) with a mean age of 47.33 +/- 12.44 years in group 1, and 18 women (60%) and 12 men (40%) with a mean age of 46.2 +/- 19.4 years in group 2. There was no significant difference between groups 1 and 2 with respect to age or gender (p = 0.801, p = 0.267, respectively). The mean duration of symptoms was 3.2 years, ranging from 1.5 to 5 years. The mean postoperative follow-up was 12.3 +/- 2.44 months. At the end of the follow-up period, the surgery success rates were 96.7% (29/30 eyes) in group 1, and 90% (27/30 eyes) in group 2. There was no statistical difference in the surgery success rates between groups (p = 0.612). Conclusion TDL-DCR is a minimally invasive and safe procedure. The lack of bleeding and incision scar and shorter operation time suggest that TDL-DCR can be a good alternative in PANDO patients.
Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model
(IJO PRESS, 2012) Dursun, Ayhan; Arici, Mustafa Kemal; Dursun, Feyza; Ozec, Ayse Vural; Toker, Mustafa Ilker; Erdogan, Haydar; Topalkara, Aysen
AIM: To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali bum-induced model of corneal angiogenesis. METHODS: Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. RESULTS: The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P<0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. CONCLUSION: Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization.
Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery
(IJO PRESS, 2011) Erdogan, Haydar; Ozec, Ayse Vural; Caner, Cengiz; Toker, Mustafa Ilker; Arici, Mustafa Kemal; Topalkara, Aysen
AIM: To evalaute the effect of fixed-combination latanoprost 0.005% /timolol maleate 0.5% and dorzolamide hydrochloride 2% /timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery. METHODS: This study is a prospective, randomized, double-masked and placebo-controlled. The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery. Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients). Two hour before surgery, the patients received one drop latanoprost/timolol (group 1), dorzolamide/timolol (group 2) and placebo (group 3, control group). The IOPs were measured at preoperative and postoperative 4, 8, and 24 hours. RESULTS: The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group. In group 1 and 2, the postoperative mean TOP [group1: (14.03 +/- 3.15)mmHg and group 2: (14.16 +/- 4.43) mmHg] at 24 hours were significantly lower than the control group [(16.93 +/- 3.70)mmHg, (P < 0.05)]. In addition, the postoperative mean IOP of group 1 [(14.90? .69)mmHg] at 8 hours was significantly lower than the control group [(17.70 +/- 3.89)mmHg, (P < 0.05)], but there was no significant difference between group 2 [(16.16 +/- 5.23)mmHg] and control group at 8 hours (P > 0.05). CONCLUSION: When compared with placebo, the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery, but did not completely prevent TOP spikes.
Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
(HINDAWI PUBLISHING CORP, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Dogan, Oznur; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Topalkara, Aysen; Arici, Mustafa Kemal; Erdogan, Haydar
Purpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in the macular and peripapillary areas were measured by using spectral domain optical coherence tomography. Results. Gender, age, and axial length did not significantly differ between the groups (all, p > 0.05). The mean values of choroidal thickness in the macular and peripapillary areas (except the superior quadrant) in the patients with PEX syndrome and PEX glaucoma were lower compared with controls (all p < 0.05). The mean values of the macular and peripapillary choroidal thickness in the PEX glaucoma group were lower compared with PEX syndrome group; however this difference was not significant. Conclusions. The findings of this study revealed that macular and peripapillary choroidal thicknesses were decreased in PEX syndrome and PEX glaucoma cases. The role of choroid in the development of glaucomatous damage in patients with PEX syndrome remains unclear.
Evaluation of Foveal Thickness and Macular Choroidal Thickness with Optical Coherence Tomography in Behcet's Disease
(Marmara Univ, Inst Health Sciences, 2021) Bozali, Erman; Erdogan, Haydar; Dursun, Ayhan; Ozec, Ayse Vural; Toker, Mustafa Ilker; Arici, Mustafa Kemal
Objective: To evaluate the foveal thickness and macular choroidal thickness on patients who were diagnosed with Behcet's Disease (BD). Methods: A total of 60 patients were included in this prospective cross-sectional study. Patients were divided into two groups. Group 1 consisted of 30 patients who were diagnosed with BD and Group 2 consisted of 30 healthy controls. Detailed ophthalmological examination was performed on both groups and foveal thickness and macular choroidal thickness were measured with Spectral-Domain Optical Coherence Tomography (SD-OCT). To measure the choroidal thickness enhanced depth imaging OCT (EDI-OCT) technique was used. Results: Mean foveal thickness in BD patients was 216.06 +/- 53.14 mu m and mean subfoveal choroidal thickness was 363.21 +/- 85.22 mu m. Mean foveal thickness and subfoveal choroidal thickness in healthy controls was 211.65 +/- 16.60 mu m and 352.83 +/- 87.11 mu m respectively. There was no statistical significance between patients with BD and patients of the control group regarding foveal and subfoveal choroidal thickness. However, anatomical deformation of Ellipsoid Zone structure in OCT had the most effect on visual acuity (p=0.001). Conclusion: This study shows that there was no statistically significant difference in terms of foveal thickness and macular choroidal thickness in patients with BD.
Evaluation of inner and outer retinal thickness in patients receiving intravitreal ranibizumab injections for diabetic macular edema
(SAGE PUBLICATIONS LTD, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Kirboga, Kadir; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal
Purpose: To measure inner and outer retinal thickness with optical coherence tomography (OCT) in patients in whom intravitreal ranibizumab was administered due to diabetic macular edema (DME) and to investigate its relation to the visual prognosis. Methods: In this retrospective case series, there were 60 consecutive eyes with DME in which intravitreal ranibizumab injection was performed for 3 times in 1-month intervals. All patients underwent full ophthalmic examination and spectral-domain OCT (SD-OCT). The total retinal thickness, the inner thickness, and the outer thickness in 4 parafoveal subfields were measured. The correlation between the retinal thickness and logMAR best-corrected visual acuity (BCVA) was investigated. Results: No significant correlation was found between the total retinal thickness in the central and other subfields and either the baseline or final visit logMAR BCVA values (p>0.05). There was a significant positive correlation between the final visit logMAR BCVA values and pretreatment inner retinal thickness in the nasal and inferior subfields (r = 0.270, p = 0.037, and r = 0.410, p = 0.001, respectively). There was significant negative correlation between the final visit logMAR BCVA values and pretreatment outer retinal thickness in nasal and temporal parafoveal subfields (r = -0.297, p = 0.021, and r = -0.268, p = 0.038, respectively). Conclusions: It could be beneficial to use inner and outer retinal thickness instead of total retinal thickness in determination of short-term prognosis in patients who had intravitreal ranibizumab injection for DME.
Intracorneal implantation of a misdirected foldable intraocular lens during phacoemulsification surgery: a case report
(Consel Brasil Oftalmologia, 2024) Toker, Mustafa Ilker; Bozali, Erman; Unal, Mustafa; Ozec, Ayse Vural; Erdogan, Haydar
| A 59-year-old man presented with a unilateral blurring of vision in his left eye. His left eye's visual acuity was hand movements level. He underwent phacoemulsification surgery, and an intrastromal posterior chamber intraocular lens was implanted. The intrastromal intraocular lens was extracted and a new intraocular lens was implanted. Usinge the Snellen chart, the final best-corrected visual acuity was 20/40. With this case report, we wish to emphasize that a single stepwise clear corneal incision merged with wound-assisted intraocular lens injections can result in intraocular lens misdirection into the corneal stroma. As a result, while performing a misdirected intraocular lens removal, we recommend that the wound be carefully constructed.
Ocular Findings in Patients with Crimean-Congo Hemorrhagic Fever
(ELSEVIER SCIENCE INC, 2009) Engin, Aynur; Erdogan, Haydar; Ozec, Ayse Vural; Elaldi, Nazif; Toker, Mustafa Ilker; Bakir, Mehmet; Dokmetas, Ilyas; Arici, Mustafa Kemal
PURPOSE: To describe ocular findings of patients with Crimean-Congo hemorrhagic fever (CCHF). DESIGN: Prospective, interventional, consecutive case series. METHODS: This study was conducted in Sivas, a city located in the central Anatolia, between July 1 and August 31, 2007. Confirmed CCHF patients were enrolled in the study and underwent ocular examination during hospitalization. RESULTS: Nineteen confirmed CCHF patients were included in this study. All patients were classified into 2 groups in terms of disease severity (severe vs nonsevere), according to the Swanepoel predictive criteria. Fourteen patients (73.7%) were classified as "nonsevere," and the remaining 5 patients (26.3%) were classified as "severe" in this study. One patient having severe disease died. Ocular findings were present in 14 patients (73.7%) and none of the patients presented any visual complaints. Ocular examination revealed that 7 patients (36.8%) had only bilateral multiple subconjunctival hemorrhage, and 2 patients (10.5%) (1 bilateral, I unilateral) had retinal hemorrhage. Five patients (26.3%) had subconjunctival hemorrhage and retinal hemorrhage. Follow-up examination 1 month later showed complete resorption of the subconjunctival hemorrhage and retinal hemorrhage. There was a statistically significant difference between patients with ocular findings and patients without ocular findings for prothrombin time (P = .011). There was no evidence of uveitis, retinal edema, sheathing of retinal vessels, or intravitreal hemorrhage in our patients. CONCLUSION: From the small sample study, CCHF caused a mild form of ocular disease. CCHF must be considered when subconjunctival or superficial retinal hemorrhages are seen in association with fever in endemic areas. (Am J Ophthalmol 2009;147:634-638. (C) 2009 by Elsevier Inc. All rights reserved.)
Pediatric Open Globe Injury in a University-Based Tertiary Hospital in the Anatolian Region
(Marmara Univ, Inst Health Sciences, 2022) Bozali, Erman; Yeter, Duygu Yalinbas; Apa, Anil Selim; Ozec, Ayse Vural; Erdogan, Haydar
Objective: Evaluation of the epidemiological and clinical features of pediatric open globe injury.Methods: Medical records of 51 patients under the age of 18 who presented to the emergency department with open globe injury (OGI) between 2009 and 2021 were evaluated retrospectively. Patient demographics, Birmingham Eye Trauma Terminology (BETT) category, pediatric ocular trauma score (POTS), visual acuity (VA), site of injury, and seasonal distribution were evaluated.Results: Of all patients included, 40 (78.4%) were male, 11 (21.6%) were female, and the mean age was 9.6 +/- 5.2 years. Zone I injury was detected in 31 (60.8%) patients. The most common cause of injury was sharp objects such as metal or wood splinters. Of all injuries, 29 (56.9%) occurred outdoors. Ocular trauma occurred more frequently in boys, especially in the summer months. Initial VA was less than 0,1 in 21 (41.2%) of the patients, between 0.1-0.5 in 9 (17.6%) and 0.6 and above in 5 (9.8%) patients. At the final visit, VA was less than 0.1 in 9 (17.6%) patients, 0.1-0.5 in 10 (19.6%) patients, and 0.6 and above in 18 (35.3%) patients. Final VA was related to the Zone and was lower as the Zone increased (p:0.011). VA and POTS scores were positively correlated at the final visit (p=0.001).Conclusion: It is substantial for emergency physicians to have a comprehensive understanding of pediatric globe injuries so that children with suspected ocular trauma should be evaluated by an ophthalmologist to prevent medicolegal problems.
Prevalence of refraction errors and color blindness in heavy vehicle drivers
(IJO PRESS, 2011) Erdogan, Haydar; Ozdemir, Levent; Arslan, Seher; Cetin, Ilhan; Ozec, Ayse Vural; Cetinkaya, Selma; Sumer, Haldun
AIM: To investigate the frequency of eye disorders in heavy vehicle drivers. METHODS: A cross-sectional type study was conducted between November 2004 and September 2006 in 200 driver and 200 non-driver persons. A complete ophthalmologic examination was performed, including visual acuity, and dilated examination of the posterior segment. We used the auto refractometer for determining refractive errors. RESULTS: According to eye examination results, the prevalence of the refractive error was 21.5% and 31.3% in study and control groups respectively (P<0.05). The most common type of refraction error in the study group was myopic astigmatism (8.3%) while in the control group simple myopia (12.8%). Prevalence of dyschromatopsia in the rivers, control group and total group was 2.2%, 2.8% and 2.6% respectively. CONCLUSION: A considerably high number of drivers are in lack of optimal visual acuity. Refraction errors in drivers may impair the traffic security.
Relationship between mean platelet volume and central serous chorioretinopathy
(SPRINGER, 2017) Dursun, Ayhan; Toker, Mustafa Ilker; Ozec, Ayse Vural; Bozali, Erman; Kirboga, Kadir; Dursun, Feyza Gulac; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa Kemal
The aim of this study was to investigate the mean platelet volume (MPV) of patients with central serous chorioretinopathy (CSCR). Thirty patients were included in the study. Thirty healthy volunteers were recruited as the control group. All patients and control subjects underwent complete ocular examination. Hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet count, and MPV of the participants were recorded. Data of patients with CSCR were compared with the control subjects. Patients with CSCR had significantly higher MPV values (9.76 +/- 1.36 fL) compared with the control subjects (8.37 +/- 0.72 fL) (p = 0.004). No significant difference was found in platelet counts between the CSCR group and the control group (259 +/- 53.75 and 243 +/- 52.11 K/Ul, p = 0.253). According to the receiver operator characteristics curve analysis, the optimal cut-off value of MPV to predict the CSCR was > 9.4, with 60.0 % sensitivity and 93.3 % specificity. Our results demonstrated that the MPV values were significantly higher in patients with CSCR. MPV may be used as a predictive tool for identifying risk for CSCR.
The Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response
(Taylor & Francis Inc, 2022) Yeter, Duygu Yalinbas; Eroglu, Serap; Sariakcali, Baris; Bozali, Erman; Ozec, Ayse Vural; Erdogan, Haydar
Purpose: To determine the association of monocyte-to-high-density lipoprotein ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) with diabetic macular edema (DME) and early anti-VEGF treatment response. Material methods: This was a retrospective and cross-sectional study conducted with 143 patients with diabetes mellitus (53 diabetic retinopathy with DME, 38 diabetic retinopathy without DME, and 52 without diabetic retinopathy). Results: 13.9 was the best cutoff value to predict DME for MHR, and 2 was for NLR (59% and 75% sensitivity and 81% and 59% specificity, respectively). Logistic regression analysis showed that NLR >= 2 and MHR >= 13.9 were significantly associated with DME prediction. However, neither NLR >= 2 nor MHR >= 13.9 was associated with central retinal thickness(CRT) or best corrected visual acuity(BCVA) outcomes after anti-VEGF treatment. On the other hand, increased NLR was associated with inferior CRT outcomes. Conclusion: MHR and NLR were simple and cost-effective biomarkers to predict DME. Moreover, higher NLR may contribute to poor CRT outcomes.
Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma
(IJO PRESS, 2015) Dursan, Feyza; Ozec, Ayse Vural; Aydin, Huseyin; Topalkara, Aysen; Darsun, Ayhan; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal
AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels. METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases, other than the diagnosis of cataract as control. Total oxidative stress (TOS), total antioxidant capacity (TAC), PON, and ARE levels in aqueous humor and serum were measured. RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group (P<0.05). TOS values were higher in patients with PEX syndrome and PEG than controls (P< 0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG.
Yag laser capsulotomy rates of 50 years and older individuals after use of the Zaraccom Ultraflex intraocular lenses
(DRUNPP-SARAJEVO, 2012) Toker, Mustafa Ilker; Ozec, Ayse Vural; Dursun, Ayhan; Yurdakul, Ismail; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa Kemal
Aim: to evaluate the rate of symptomatic posterior capsule opacification requiring Nd:YAG capsulotomy in patients who underwent cataract extraction and implantation of zaraccom ultraflex lenses (one-piece hydrophobic acrylic square edged intraocular lens). Methods: 142 eyes of 103 patients who had cataract extraction and implantation of zaraccom ultraflex lenses (IOLs) were evaluated for rate of nd:yag capsulotomy from april 2008 to august 2009. The cases that received Nd:YAG capsulotomies were evaluated for visual acuity, lens position and centralization and the frequency of nd: yag laser determined. Results: the mean preoperative best corrected visual acuity (BCVA) was 0.31 +/- 0.20 And the final mean BCVA was 0.96 +/- 0.06 With snellen chart. The rate of nd: yag capsulotomy was 0.7%. The mean time to Nd: YAG capsulotomy was 24.34 Months (range: 12 to 30 months). Conclusion: posterior capsule opacification was significantly less for the patients 50 years and over with the Zaraccom Ultraflex IOLs at 2 years.

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