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Öğe Case of Salivary Cyst in a Aseel Rooster(Van Yüzüncü Yıl Üniversitesi, 2016) Alkan, İsmail; Kuşçu, Yağmur; Sancak, Tunahan; Atasoy, Nazmi; Arı, Hasan Hüseyin; Uslu, SemaThis case consists of ten months old aseel rooster that was consulted to YYU, Surgery Clinic of Veterinary Medicine. Information of swollen in cavum oris, wheezing, anorexia, loss of weight were obtained in anamnesis. Patient was examined with this anamnesis. Cystic formation that is soft and noticing with palpation was determined in the salivary glands of the palate and dorsal wall of the pharynx. Operation was performed to cystic formation which is thought in gll. mandibulares. Caseous content was emptied. Cavity was irrigated with teinture d’iode. For microbiological and histological evaluation, samples were taken from content and cyst wall. In microbiological evaluation Streptoccusspp was determined. In histopathologic evaluation proliferation of Stratum spinozum cells, diversity in submucosal histiocytes and proliferation in macrophages were determined. Glycerin iode and systematic antibiotics were advised.Öğe Determination of the causative agent of periparturient period interdigital dermatitis that adversely affects reproduction and milk production in cows by MALDI-TOF(Revista Pesquisa Veterinaria Brasileira, 2023) Takci, Abdurrahman; Mogulkoc, Mahmut Niyazi; Sancak, Tunahan; Kivrak, Mehmet BugraIn recent years, problems associated with high milk yield in dairy cows have increased considerably. Today, interdigital dermatitis (ID) is one of the most significant problems across the dairy industry, threatening animal health and welfare and inducing serious productivity losses. The etiology and mechanism of damage caused by this disease, which disrupts quality of life, milk yield, and reproduction, have not yet been fully understood. In order to achieve the study objectives, 40 biparous cows (3 years old - second calving) that had lameness associated with ID from prepartum day 30 to postpartum day 60 (Study group) and 40 biparous cows (3 years old) without lameness symptoms during the specified period (Control group) constituted the material of the present study. There was no difference in the levels of non-esterified fatty acids in the blood samples collected from those animals during the dry period (45-60 days before parturition; P=0.38). There were differences between the groups in certain parameters, including beta-hydroxybutyric acid level in the postpartum period, weight loss in the first month, number of ovarian cysts in the first 60 days, milk production in the first month, and the first corpus luteum determination process. (P<0.001) There was no difference between the groups in terms of reproductive parameters (mode of delivery, litter viability, litter weight, litter weight, expulsion of membranes, etc.) and presence of infection (acute puerperal metritis) during birth (P>0.05 for all parameters). In addition to all of the above, Wohlfahrtiimonas chitiniclastica bacteria were isolated for the first time in microbiological samples collected from ID, which is a significant condition for dairy cows during the periparturient stage, contributing to the etiology of the disease, which has not been understood so far.Öğe Determination of the causative agent of periparturient period interdigital dermatitis that adversely affects reproduction and milk production in cows by MALDI-TOF1(2023) Takçı, Abdurrahman; Moğulkoç, Mahmut Niyazi; Sancak, Tunahan; Kıvrak, Mehmet BuğraIn recent years, problems associated with high milk yield in dairy cows have increased considerably. Today, interdigital dermatitis (ID) is one of the most significant problems across the dairy industry, threatening animal health and welfare and inducing serious productivity losses. The etiology and mechanism of damage caused by this disease, which disrupts quality of life, milk yield, and reproduction, have not yet been fully understood. In order to achieve the study objectives, 40 biparous cows (3 years old – second calving) that had lameness associated with ID from prepartum day 30 to postpartum day 60 (Study group) and 40 biparous cows (3 years old) without lameness symptoms during the specified period (Control group) constituted the material of the present study. There was no difference in the levels of non-esterified fatty acids in the blood samples collected from those animals during the dry period (45-60 days before parturition; P=0.38). There were differences between the groups in certain parameters, including beta-hydroxybutyric acid level in the postpartum period, weight loss in the first month, number of ovarian cysts in the first 60 days, milk production in the first month, and the first corpus luteum determination process. (P<0.001) There was no difference between the groups in terms of reproductive parameters (mode of delivery, litter viability, litter weight, litter weight, expulsion of membranes, etc.) and presence of infection (acute puerperal metritis) during birth (P>0.05 for all parameters). In addition to all of the above, Wohlfahrtiimonas chitiniclastica bacteria were isolated for the first time in microbiological samples collected from ID, which is a significant condition for dairy cows during the periparturient stage, contributing to the etiology of the disease, which has not been understood so far.Öğe Experimental study of in-vitro bioanalysis and in-vivo living tissue biocompatibility of Mg-Zn alloys(Springer Heidelberg, 2023) Comba, Bahat; Cicek, Bunyamin; Comba, Arzu; Sancak, Tunahan; Akveran, Gonul Arslan; Koc, Erkan; Sun, YavuzIn this study in-vitro bioanalysis and in-vivo living tissue biocompatibility were evaluated. Pure Mg and Mg + x Zn (x = 1 and 3 wt%) alloys have been used in the study. In vitro immersion and potentiodynamic corrosion were applied to these alloys in Hank's and artificial seawater solution. The materials were kept in living tissue (gluteus-superficial) for 7 weeks in-vivo (albino-rat). After 4 and 7 week, the control and experimental groups' urine parameters, blood mineral substance levels, and radiographic image controls were evaluated. It was observed that the bio-dissolution level decreased as the Zn-ratio increased. As a result, successful results were obtained in the biocompatible and biodegradable material class of Zn-doped Mg alloys used in the study. The dissolution amount of 1.03 mm/y (for Mg + 3Zn alloy) in Hank's solution was calculated. The % vitality was determined at the level of 117%.Öğe Histopathological and Biochemical Investigation of the Effect of Shilajit on Liver and Kidney in Rats with Experimental Spinal Cord Injury(2023) Sancak, Tunahan; Okulmuş, Çağlar; Akyol, Mehmet Edip; Keleş, Ömer Faruk; Çetin, EyüpObjective: In this study, it was aimed to determine the effect of shilajit on the liver and kidney in rats with experimental spinal cord injury. Materials and Methods: Spinal cord injury-induced rats were treated with shilajit at doses of 150 mg/kg and 250 mg/kg on days 1, 2, and 3. Following the administration, rats were sacrificed on the 14th day, and blood, liver, and kidney tissues were collected. Results: The histopathological analysis of the liver and kidney revealed that high doses of shilajit showed a greater protective effect in the tissues and low doses showed only a partial protective effect. In biochemical analysis, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine, and urea concentrations were lower and albumin (ALB) and total protein (TP) concentrations were higher in shilajit-treated groups compared with the control group (P range: 0.05–0.001). Conclusion: As a result, in this study, it has been histopathologically and biochemically revealed that administration of the Shilajit significantly suppressed the formation of the lesions in liver and kidney with its anti-inflammatory properties after spinal cord injury in rats.Öğe Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury(Turkish Assoc Trauma Emergency Surgery, 2023) Cetin, Eyup; Sancak, Tunahan; Keles, Omer Faruk; Unlu, Ilker; Akyol, Mehmet Edip; Arabaci, OzkanBACKGROUND: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI). METHODS: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. High-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 250 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. Thin sections taken from the spinal cord after euthanasia were sent for histopathological and immunohistochemical examination. RESULTS: Histopathological examination of the high-dose group showed lower amounts of morphological findings compared to the low-dose group and control group. While a significant CD68 immune reaction was observed in the control group of rats with spinal injury, the positive immune reaction was found to be significantly decreased in the Shilajit-applied groups. CONCLUSION: It is thought that the use of Shilajit in SCI will reduce the effects of secondary damage in SCI and that its administration to such patients will have positive effects on the results.Öğe Serum Immunoglobulin and Nitric Oxide Levels in Calves with Arthritis and Omphalitis(Dicle Üniversitesi, 2023) Kayıkcı, Caner; Gençcelep, Musa; Karasu, Abdullah; Özkan, Cumali; Aslan, Loğman; Sancak, TunahanOmphalitis and arthritis are diseases that are frequently encountered in calves and cause serious economic losses. In this study, it was aimed to determine serum immunoglobulin and NO levels in calves with omphalitis and arthritis and to examine the changes in these parameters compared to healthy calves. The animal material of this study consisted of calves with arthritis (n=20) and omphalitis (n=20) and calves (control group n=15) with clinically healthy from Van region. Clinical and radiological examinations were carried out, and blood samples were collected. Immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), gamma-glutamyl transferase (GGT) and nitric oxide (NO) levels were determined by ELISA. In our study, mean blood serum IgA, IgM, IgG, GGT, and NO levels of calves with arthritis were found to be 0.55 mg/ml, 4.63 mg/ml, 4.33 mg/ml, 29.63 ng/ml, and 624.1 µmol/l, respectively. Mean blood serum IgA, IgM, IgG, GGT and NO levels of calves with omphalitis were 0.52 mg/ml, 4.39 mg/ml, 2.04 mg/ml, 28.51 ng/ml, 538.75 µmol/L respectively. In conclusion, no significant statistical difference was observed between serum IgA, IgM, IgG, and GGT levels of animals diagnosed with omphalitis and arthritis. While in the omphalitis group, no statistical significance was observed for the NO serum levels, a statistical significance was present in the arthritis group.Öğe Siyatik sinir yaralanması oluşturulan ratlarda Andız (Juniperus sp) kökü ekstraktının ve B12 vitamininin sinir iyileşmesi üzerine etkisinin karşılaştırılması(Sivas Cumhuriyet Üniversitesi, 2023) Sancak, Tunahan; Çetin, EyüpPeriferik sinirlerin kendi kendini onarma kapasitesi sınırlıdır ve ciddi şekilde hasar görmüş veya önemli kusurları olanların onarımı zordur. Bu nedenle periferik sinir rejenerasyonu ile ilgili klinik öncesi çalışmalar için en sık kullanılan deneysel model, siyatik sinir yaralanması modelidir. Ratlarda siyatik sinir yaralanması, periferik sinir rejenerasyonu ile ilgili çalışmalarda en çok kullanılan modeldir. Materyal Metot: Bu çalışmada 32 rata siyatik sinir yaralanması sonrası B12 vitamini ve Andız kökü ekstraktı uygulamaları yapılmıştır. Uygulamalar sonrasında ratlar 21. günde sakrifiye edilerek siyatik sinir doku örnekleri alınmıştır. Alınan örnekler histopatolojik ve immunofloresan yöntemlerle incelenmiştir. Bulgular: İncelenme B12 ve Andız kökü ekstraktının ayrı ayrı uygulandığı ratlarda histopatolojik olarak sınırlı düzeyde ve benzer şekilde fayda sağladığı, birlikte uygulanan grubun ise tüm gruplara göre daha etkili pozitif yönde etki sağladığı görülmüştür. Ayrıca immunofloresan yöntemle S100 ve GFAP ekspresyonunda da ayrı ayrı uygulamaların benzer şekilde fayda sağladığı görülürken, birlikte uygulama yapılan grupta ise diğer tüm gruplara kıyasla daha iyi katkı sağladığı görülmüştür. Sonuç: Sonuç olarak ratlarda uygulanan siyatik sinir yaralanması modelinde iyileşme düzeylerinin belirlenmesi için ayrı ayrı uygulanan Andız kökü ekstraktı ve B12 vitaminin kontrol grubuna göre sınırlı düzeyde ve benzer şekilde etki oluşturduğu, birlikte uygulandığında ise sinerjik etki göstererek diğer tüm gruplara göre sinir iyileşmesine daha etkili bir şekilde katkı sağladığı belirlenmiştir.Öğe The effects of repeated doses of xylazine-ketamine and medetomidine- ketamine anesthesia on DNA damage in the liver and kidney(Acta Cirurgica Brasileira, 2023) Sancak, TunahanPurpose: This study evaluated the DNA damage caused by repeated doses of xylazine-ketamine and medetomidine-ketamine anesthesia in the liver and kidneys.Methods: In this study, 60 rats were used. The rats were divided into group 1 (xylazine-ketamine), and group 2 (medetomidine-ketamine), and these anesthetic combinations were administered to the rats at repeated doses with 30-min intervals. The effects of these anesthetic agents on the tumor necrosis factor-alpha gene for DNA damage were investigated.Results: According to the gene expression results, it was observed that a single dose of xylazine-ketamine was 2.9-fold expressed, while first and second repeat doses did not show significant changes in expression levels. However, in the case of the third repetition, it was observed to be 3.8-fold overexpressed. In the case of medetomidine-ketamine administration, it was observed that a single-dose application resulted in a 1.04-fold expression, while the first and the third repeat doses showed a significant down expression. The samples from the second repeat dose administration group were found to have insignificant levels of expression.Conclusion: This study can contribute to understanding the safe anesthetic combination in research and operations in which xylazine-ketamine and medetomidine-ketamine combinations are used.Öğe Yara İyileşmesinde Centella Asiatica Ekstraktı, Çinko Oksit ve Alaptidum İçeren Merhemlerin Etkinliğinin Klinik ve Histopatolojik Olarak Karşılaştırılması(2022) Korkmaz, Murat; Sancak, TunahanYara, canlı dokunun anatomik ve fiziksel bütünlüğünün bozulmasına bağlı olarak; dokunun mevcut fizyolojik faaliyetlerinin tamamının veya bir kısmının ortadan kalktığı durum olarak tanımlanabilir. Günümüzde yara iyileşmesini hızlandırmak ve süreci kısaltmak adına farklı birçok tedavi protokolü güncel yara tedavilerinde sıklıkla kullanılmaktadır. Gelişen teknoloji ve tıp alanındaki gelişmelere bağlı olarak ortaya çıkan medikal ürünler tedavinin seyrinide etkilemiştir. Bu çalışmada Winstar albino ratlarda oluşturulan kesik yaralarında, C. asiatica ekstraktı, çinko oksit ve alaptidum içeren merhemlerin yara iyileşmesi üzerine olan etkilerinin histopatolojik olarak incelenmesi amaçlanmıştır. Bu amaçla 36 adet winstar ırkı rat rastgele önce onikişerli daha sonra bu gruplar kendi aralarında altışarlı gruplara ayırılmıştır. Oluşturulan çalışma grupları 5. ve 10. gün olmak üzere gruplandırılmıştır. Gruplara genel anastezi altında tıraş ve dezenfeksiyonun ardından sırtın sağ ve sol bölgesine tüm katları içerecek şekilde 2 adet kesik yarası oluşturulmuş ve bu yaralara sabah akşam olmak üzere merhemler uygulanmıştır. 5. ve 10. gün sonunda sakrifiye edilen ratlardan alınan örnekler laboratuvara histopatolojik inceleme için gönderilmiştir. Yapılan çalışma sonunda alaptidum ve çinko oksit içeren merhemlerin uygulandığı gruplarda epitelyal rejenerasyonun daha erken tamamlandığı ve dermiste fibrovasküler bağ doku proliferasyonunun daha erken olgunlaştığı görülmüştür.Öğe Yara İyileşmesinde Centella Asiatica Ekstraktı, Çinko Oksit ve Alaptidum İçeren Merhemlerin Etkinliğinin Klinik ve Histopatolojik Olarak Karşılaştırılması(Van Yüzüncü Yıl Üniversitesi, 2022) Korkmaz, Murat; Sancak, TunahanYara, canlı dokunun anatomik ve fiziksel bütünlüğünün bozulmasına bağlı olarak; dokunun mevcut fizyolojik faaliyetlerinin tamamının veya bir kısmının ortadan kalktığı durum olarak tanımlanabilir. Günümüzde yara iyileşmesini hızlandırmak ve süreci kısaltmak adına farklı birçok tedavi protokolü güncel yara tedavilerinde sıklıkla kullanılmaktadır. Gelişen teknoloji ve tıp alanındaki gelişmelere bağlı olarak ortaya çıkan medikal ürünler tedavinin seyrinide etkilemiştir. Bu çalışmada Winstar albino ratlarda oluşturulan kesik yaralarında, C. asiatica ekstraktı, çinko oksit ve alaptidum içeren merhemlerin yara iyileşmesi üzerine olan etkilerinin histopatolojik olarak incelenmesi amaçlanmıştır. Bu amaçla 36 adet winstar ırkı rat rastgele önce onikişerli daha sonra bu gruplar kendi aralarında altışarlı gruplara ayırılmıştır. Oluşturulan çalışma grupları 5. ve 10. gün olmak üzere gruplandırılmıştır. Gruplara genel anastezi altında tıraş ve dezenfeksiyonun ardından sırtın sağ ve sol bölgesine tüm katları içerecek şekilde 2 adet kesik yarası oluşturulmuş ve bu yaralara sabah akşam olmak üzere merhemler uygulanmıştır. 5. ve 10. gün sonunda sakrifiye edilen ratlardan alınan örnekler laboratuvara histopatolojik inceleme için gönderilmiştir. Yapılan çalışma sonunda alaptidum ve çinko oksit içeren merhemlerin uygulandığı gruplarda epitelyal rejenerasyonun daha erken tamamlandığı ve dermiste fibrovasküler bağ doku proliferasyonunun daha erken olgunlaştığı görülmüştür.
