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Öğe Evaluation of conus medullaris level in newborn infants(Cukurova Univ, Fac Medicine, 2023) Yildiz, Bulent; Tunc, Gaffari; Soylemez, BurcakPurpose: Previous studies have reported that the conus medullaris (CM) is located between T12 and L2 in most adults, but no significant ascent has been observed during childhood. There is evidence that the normal position of the CM in an adult is acquired at birth in the majority of cases. Studies have shown that there are differences in CM levels in neonates. This situation causes problems for interventional procedures in the neonatal period. The aim of this study is to determine CM levels in preterm/term neonates using ultrasound (US).Materials and Methods: Newborn infants (gestational age: 24-43 weeks) admitted to the neonatal intensive care unit between March 2020 and June 2021 were evaluated for CM levels by the postnatal US. Infants with central nervous system abnormalities, dysmorphic features, somatic or various genetic diseases, or their parent's refusal to participate were excluded from the study.Results: Of the 189 neonates infants included in our study, 85 (44.6%) were female, 104 (55.4%) were male, 139 (73.54%) were preterm (24-36 weeks), and 50 (26.46%) were term (37-42 weeks) neonates. As a result of the US performed on the first day of 189 neonates, CM levels, 31 (16.4%) were L1, 31 (16.4%) were L1-2, and 71 (37.6%) were L2. There is a strong correlation between birth weight and birth week (r 0.84). There is a negative relationship between birth weight and CM level (r-0,20), gestational age, and CM level (r-0,23).Conclusion: Conus medullaris level was negatively correlated with gestational age and increased with advancing gestational age. In addition, the CM level shows a slower rise at 28-40 weeks of postmenstrual age and reaches the normal level (L1-L2) in the neonatal period, as in adults. Knowing the level of the CM in the newborn period will ensure that spinal procedures such as lumbar puncture to be applied to the spinal region can be performed safely.Öğe Evaluation of the Neurotoxicity of Strontium and Glycyrrhiza Glabra: First Report(Turkish Neurosurgical Soc, 2021) Soylemez, Burcak; Sahin-Bolukbasi, SerapAIM: To investigate the neurotoxic effects of strontium (Sr) compounds and Glycyrrhiza glabra (licorice, G. glabra). MATERIAL and METHODS: In this study, we conducted neurotoxicity assays on the human cortical neuronal cell line HCN-2 (CRL-10742) to determine the potential neurotoxic effects of Sr and G. glabra. RESULTS: No significant decrease in HCN-2 cell viability was observed with longer Sr exposure or Sr concentrations up to 2000 mu g/mL. The IC50 values of Sr for 24 and 48 hours of exposure were >2000 mu g/mL, and 936.9 +/- 0.09 mu g/mL for 72 hours. However, we observed a significant reduction in HCN-2 cell viability with longer exposure and higher concentrations of G. glabra. The IC50 values of G. glabra for 24, 48, and 72 hours were 545.1 +/- 0.03 mu g/mL, 398.1 +/- 0.03 mu g/mL, and 393.3 +/- 0.02 mu g/mL, respectively. CONCLUSION: Additional studies are needed to further investigate the neurotoxicity of Sr and G. glabra, and elucidate the pathway by which these compounds exert their therapeutic effects in pathological conditions.Öğe Investigating the Potential of Lipids for Use as Biomarkers for Glioblastoma via an Untargeted Lipidomics Approach(Korean Neurosurgical Soc, 2023) Soylemez, Burcak; Bulut, Zekeriya; Bolukbas, Serap SahinObjective : The types and functions of lipids involved in glioblastoma (GB) are not well known. Lipidomics is a new field that examines cellular lipids on a large scale and novel aplication of lipidomics in the biomedical sciences have emerged. This study aimed to investigate the potential of blood lipids for use as biomarkers for the diagnosis of GB via untargated lipidomic approach. Gaining a deeper understanding of lipid metabolism in patients with GB can contribute to the early diagnosis with GB patiens and also development of novel and better therapeutic options.Methods : This study was performed using blood samples collected from 14 patients (eight females and six males) and 14 controls (eight females and six males). Lipids were extracted from blood samples and quantified using phosphorus assay. Lipid profiles of between patients with GB and controls were compared via an untargeted lipidomics approach using 6530 Accurate-Mass Q-TOF LC/MS mass spectrometer.Results : According to the results obtained using the untargeted lipidomics approach, differentially regulated lipid species, including fatty acid (FA), glycerolipid (GL), glycerophospholipid (PG), saccharolipid (SL), sphingolipid (SP), and sterol lipid (ST) were identified between in patients with GB and controls.Conclusion : Differentially regulated lipids were identified in patients with GB, and these lipid species were predicted as potential biomarkers for diagnosis of GB.Öğe Neural tube defect family with recessive trait linked to chromosome 9q21.12-21.31(SPRINGER, 2015) Bayri, Yasar; Soylemez, Burcak; Seker, Askin; Yuksel, Sirin; Tanrikulu, Bahattin; Unver, Olcay; Canbolat, Cagri; Sakar, Mustafa; Kardag, Ozen; Yakicier, Cengiz; Dagcinar, Adnan; Ziyal, Ibrahim; Bayrakli, FatihMeningomyelocele is one of the most common and socioeconomically, psychologically, and physically debilitating neurodevelopmental diseases. A few chromosomal locus and genes have been identified as responsible for the disease; however, clear evidence still needs to be produced. This study aimed to show evidence of a strong genetic linkage in a novel chromosomal locus in a family with this neural tube defect. We identified a neural tube defect family in eastern Turkey, where two of six offspring had operations due to thoracolumbar meningomyelocele. The parents were of a consanguineous marriage. We collected venous blood from six offspring of the family. Whole genome linkage analysis was performed in all offspring. A theoretical maximum logarithm of an odds score of 3.16 was identified on chromosome 9q21.12-21.31. This result shows a strong genetic linkage to this locus. Our results identified a novel chromosomal locus related to meningomyelocele and provide a base for further investigations toward the discovery of a new causative gene.Öğe One-Year Outcome Comparison of Polyetheretherketone Cage and Disc Prosthesis in Cervical Disc Replacement Surgery(Erciyes Univ Sch Medicine, 2022) Irmak, Aysegul; Soylemez, BurcakObjective: Anterior cervical microdiscectomy (ACD) is an established surgical method to treat cervical disc disease. Since ACD changes the natural distribution of biomechanical forces, grafts are often used. The most commonly used grafts are a polyetheretherketone (PEEK) cage or a cervical disc prothesis (CDP). This study is a comparison of the early period results of single-level ACD performed using a PEEK cage or a CDP. Materials and Methods: A total of 80 patients with a single-level cervical disc herniation who underwent ACD with PEEK cage (n=40) or CDP (n=40) implantation between 2015-2018 at a single center were retrospectively evaluated. The Cobb angle, T1-slope angle, segmental fusion angle, cervical-tilt angle, and disc height at the operated level were measured using cervical lateral radiographs and magnetic resonance images obtained preoperatively and at 1 day, 1 month, and 12 months postoperative. Neck pain was also evaluated pre- and postoperatively. Results: No statistically significant difference was seen between the groups in the parameters measured at the first and 12th months (p=0.481). In both groups, the preoperative and 12th-month measurements were found to be statistically significant (p=0.001). The development of adjacent segment disease (ASD) was not statistically different between groups. Conclusion: Although a CDP has some advantages in short-term outcomes, there is still insufficient evidence regarding long-term outcomes, particularly regarding the prevention of ASD. CDP implantation offers an earlier return to work and no requirement for an external cervical orthosis, but due to the high cost and some specific complications, such as implant dislocation, heterotopic ossification, and fusion, CPD is still far from a gold-standard treatment option, even for selected cases.Öğe An unusual condition during internal jugular vein catheterisation: vertebral artery catheterisation(CLINICS CARDIVE PUBL PTY LTD, 2016) Korkmaz, Ozge; Goksel, Sabahattin; Soylemez, Burcak; Durmus, Kasim; Isbir, Ahmet Cemil; Berkan, OcalVertebral artery cannulation is an unusual complication during internal jugular vein cannulation. We report a case of vertebral artery cannulation, which occurred during an attempt to cannulate the right internal jugular vein, and we discuss the management of such a rare complication.Öğe Variation in the BRCA2 gene in a child with medulloblastoma and a family history of breast cancer(AMER ASSOC NEUROLOGICAL SURGEONS, 2011) Bayrakli, Fatih; Akgun, Bekir; Soylemez, Burcak; Kaplan, Metin; Gurelik, MustafaThe fact that BRCA genes operate as tumor suppressors is evident from the genetics of the different human disorders caused by inherited mutations. Germline mutations affecting 1 allele of either BRCA1 or BRCA2 confer susceptibility to different types of cancers such as breast cancer and medulloblastoma. A family with a history of cancer was identified in Eastern Turkey in which one of the family members (a 13-year-old boy) had medulloblastoma. Venous blood was collected from available family members. The BRCA1 and BRCA2 genes were sequenced in the patient with medulloblastoma and the healthy father. An Asn372His homozygous variation was noted in the BRCA2 gene in the patient with medulloblastoma whereas the variation was heterozygous in the healthy father. A biallelic homozygous variation was demonstrated in the BRCA2 gene, which is important in medulloblastoma suppression, and may have caused medulloblastoma formation in the 13-year-old boy. Further investigations in large human populations with medulloblastoma are necessary for further delineation of BRCA gene malfunctions and their relationship to medulloblastoma formation, and to clarify the therapeutic implications of these malfunctions. (DOI: 10.3171/2011.8.PEDS11210)
