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Öğe INVESTIGATION OF STRUCTURAL PROPERTIES OF FERROCENE-DERIVED CHALCON COMPOUNDS(Koray SAYIN, 2025) Tüzün, Gamze; Sayin, KorayFerrocene derived chalcone compounds were completed at M06-2X/6-31+G(d)(LANL2DZ) level in water phase. Structural properties (geometric structure, bond lengths and angles), spectral electronic properties and nonlinear optical properties (NLO) of the relevant compounds were examined. Geometric parameters of these compounds and their electronic structures were reported. HOMO-LUMO energy gap (6.35-6.77 eV) indicated high stability of the compounds, while MEP maps revealed that carbonyl oxygens have biological interaction potential. IR spectra of ferrocene derived chalcone compounds were calculated in water phase. Absorption bands were observed between 190-285 nm in UV-Vis spectrum. In NLO analysis, FC9 and FC10 compounds were determined to have high second-order polarizability (βtot) values (FC10: 1892.80 a.u.), and FC6 compound had the highest dipole moment (1.98 Debye). Overall, the calculated molecular parameters indicate that ferrocene-derived chalcone compounds have the potential to interact with biological and chemical systems. These findings provide a theoretical basis for further experimental studies and are suggested to be evaluated in pharmaceutical and biotechnological applications.Öğe Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds(2021) Gezegen, Hayreddin; Tutar, Uğur; Hepokur, Ceylan; Tüzün, Gamze; Atioğlu, Zeliha; Akkurt, MehmetA series of novel racemic ...Öğe Multifunctional Magnetic Nanoparticles in the Separation and Detection of Biological Molecules: Proteins, Enzymes, and Nucleic Acid(CRC Press, 2024) Kul, I˙layda Bersu; Tüzün, Gamze; Tüzün, Burak; Berdimurodov, Elyor; Rbaa, MohamedThis chapter showcases the various advantages of magnetic nanoparticles. It emphasizes the importance of nanoparticles in the identification and isolation of biological molecules such as proteins, nucleic acids, and enzymes. First, the basic properties and synthesis methods of magnetic nanoparticles are explained in detail, especially the interaction with proteins, nucleic acids, and enzymes. The importance of magnetic nanoparticles in the separation and purification of various biological molecules is emphasized. Finally, this chapter explains the functions of magnetic nanoparticles in the field of biomedicine and medicine, as well as in the diagnosis of various diseases. © 2025 selection and editorial matter, Edited by Elyor Berdimurodov, Chaudhery Mustansar Hussain, and Burak Tüzün; individual chapters, the contributors.Öğe MXenes in drug delivery(Elsevier, 2024) Alikhanian, Alireza; Montazer, Mohammad Nazari; Ahmadi, Baharan; Mahdavi, Mohammad; Sadeghian, Nastaran; Tüzün, Gamze; Tuzun, Burakbefore synthesizing MXenes a lot of two-dimensional (2D) structures were synthesized and various researches about these structures has done for years, but after 2011 that MXenes were discovered, and the number of 2D transition metal carbides and nitrides (MXenes) has progressively introduced. Those structures had applications in different fields. One field of interest is biology, and many biological applications have been suggested, such as drug delivery; in this chapter, we will explain important parameters and features in choosing components for drug delivery applications; for instance, cellular uptake, biocompatibility, and biodistribution. And focus on some MXene-based structures which are the best example of drug delivery application of MXenes introduced in different studies for instance MXene/cobalt, MXene/agarose hydrogel, and MXene/AuNRs. These structures not only have stable structures and well-synthesized methods but also have all of the crucial features (such as cellular uptake, biocompatibility, and biodistribution) for a good drug delivery component. © 2024 by Elsevier Inc. All rights reserved, including those for text and data mining, AI training, and similar technologies.Öğe MXenes synthesis and characterization(Elsevier, 2024) Ahmadi, Baharan; Montazer, Mohammad Nazari; Bozorg, Ali; Mahdavi, Mohammad; Sadeghian, Nastaran; Tüzün, Gamze; Tuzun, BurakBecause of their adaptive nature and great surface chemistry, two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides, often called MXene, are versatile materials. Physical and chemical diversity has defined MXenes as a promising 2D material with many applications. MXenes are prepared by selectively etching particular atomic layers from their layered precursors, known as the MAX phase. Synthesized MXenes prepared by hydrofluoric acid etching have an accordion-like morphology, referred to as multilayer MXene or, when less than five layers, several layers MXene. In light of the remarkable advances in the MXene field, it is appropriate to examine the most relevant properties of these MXenes and highlight their potential applications. The purpose of this section is to review the most important fundamental and technological aspects, and synthesis aspects of MXenes, ranging from the structural and physicochemical properties of these compounds to their potential applications and devices, with a focus on medical applications and drug delivery. © 2024 by Elsevier Inc. All rights reserved, including those for text and data mining, AI training, and similar technologies.Öğe Nanoengineering and nanoscience: Current and emerging trends(De Gruyter, 2023) Kütük, Nurşah; Gürbüzer, Aslihan; Tüzün, Gamze; Tüzün, BurakThe study of science at the nanoscale has become one of the most important research topics in recent years. Almost all branches of science are interested in nano-technology. Metal and metal oxides, carbon family products, polymers, clays and composites are some of the nanomaterials used. Despite their small size, nanomaterials have different properties such as large surface area, different particle shape and size, pore volume, biocompatibility and biodispersibility. For this reason, nanotechnology has also spread to the industry. Due to their unique properties, nanomaterials are widely used in medical, water treatment, sensor and environmental applications. Although nanotechnology research has accelerated especially in recent years, there are still many unexplored materials and application areas. The aim of this study is to investigate the advantages and disadvantages of nanomaterials and nanotechnology applications by examining their usage areas in scientific and industrial fields. ©2023 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.Öğe Origanum sipyleum L. (mor mercan) ekstraktının meme kanseri hücre hatlarında antiproliferatif özelliklerinin incelenmesi(Sivas Cumhuriyet Üniversitesi, 2019) Tüzün, Gamze; Hepokur, CeylanKanser, hücrelerin kontrolsüz olarak sürekli çoğalmaları sonucu gelişen tedavi edilmediği takdirde insanı ölüme götüren bir hastalıktır. Meme kanseri dünyada kadınlar arasında en sık görülen maling tümör olup, metastaz yapmaya yatkın özelliği ile kanser ölümlerinde başlıca sıralardadır. Kanser tedavisi sonucu görülen yan etkiler bu hastalığın tedavi oranındaki yüzdesini düşürmektedir. Bu nedenle sağlık alanındaki çalışmalar kanser de yeni tedavi methodlarına kaymıştır. Yapılan çalışmalar sonucunda doğal ürünlerin yeni antikanser ajanlar geliştirmek için önemli hedef hale gelmiştir. Origanum türüne ait çok sayıda bitki bulunmaktadır. Bu bitki türleri uçucu ve aromatik yağlar, sekonder metabolitler nedeniyle birçok sektörde ekonomik öneme sahiptir. Bu bitki türleri genel olarak öksürüğü tedavi etmede, midede gerçekleşen ağrılarda ve bulaşıcı hastalıkların tedavisinde, yaygın olarak kullanılmaktadır. Bu çalışmada endemik tür olan Origanum sipyleum L. (mor mercan) ekstraktının meme kanser hücre hatlarında antioksidan ve antiprpliferatif özellikleri incelenmiştir. Böylece kanser tedavisi için etkili bir terapötik ajan geliştirilmesi hedeflenmektedir.
