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Öğe Current clinical recommendations and applications for the uses of platelet rich plasma(Nova Science Publishers, Inc., 2024) Yurtcu, Nazan; Güler, EmelThis first edition of Current Clinical Recommendations and Application for Use of Platelet Rich Plasma is written by many of the leading scientists and clinicians who have been responsible for the dramatic progress in platelet rich plasma use. The purpose of the book is to deal with all aspects of its usage areas. The authors have met the expectation that practice guidelines be based either on convincing available evidence or on consensus statements of authoritative organizations. The book will be useful for dermatologists, obstetricians, urologists, orthopedics, physical therapy, and rehabilitation specialists. © 2024 by Nova Science Publishers, Inc. All rights reserved.Öğe Current trends in breast disease management(Nova Science Publishers, Inc., 2024) Aslan, Adem; Yurtcu, Nazan; Güler, Mustafa CanAlthough breast tissue is in both sexes, it is more active and functional in women than in men. Breast tissue, which includes morphological and functional changes, including pre-puberty, reproductive and later periods, can be exposed to various diseases directly or indirectly related to all these changes. The human breast, especially in women, hosts a wide array of health conditions that range from simple to diagnose and treat, to diseases with high morbidity and mortality. Therefore, it also concerns multidisciplinary approaches that include different medical departments, not a single medical department. Considering all this, an updated approach to breast diseases will always be necessary. Within the scope of this book, an up to-date work will be created by treating breast tissue as anatomical, physiological and clinical by experts in the field. © 2024 by Nova Science Publishers, Inc. All rights reserved.Öğe Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death(2023) Ünal, Gamze Sönmez; Albak, Yasemin; Yurtcu, Nazan; Yıldız, Çağlar; Çetin, Meral; Daştan, Sevgi Durna; Gümüş, ErkanObjective: This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model. Materials and Methods: Five groups were formed with eight animals in each group. One of the groups was set as the control group. Endometriotic lesions were created by transplanting 40 mouse autologous endomyometrial tissues into the mouse subcutaneous tissue to a highly vascular surface. Gene expression analyzes of tissues were performed as HIF-1a, ATG5, ATG12, Beclin2, Beclin1, LC3BII, CateninB, GSK3b, TCF, WNT2, WNT7a, and WNT10a gene analyzes. Drug effects were examined by histological examination. HIF1a and WNT2 protein expressions were examined immunohistochemically. Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables. Data are presented as mean and standard error. Results: Beclin2 gene expression coefficients of metformin 1st day, metformin 7th day, ganirelix 1st day, and general 7th day groups were found to have significantly decreased compared with the control group coefficient. Beclin1 gene expression coefficients of metformin 1st day, metformin 7th day, ganirelix 1st day, and genirelix 7th day groups were found to have significantly decreased compared with the control group coefficient. LC3BII gene expression coefficients of metformin 1st day and metformin 7th day groups were found to have significantly decreased compared withLC3BII gene expression coefficients of control, genirelix 1st day, and genirelix 7th day groups. These findings were supported by histological and immunohistochemical staining. Conclusion: These genes are actively involved in the autophagy pathway, and we think that the use of metformin in endometriosis might create an autophagy-based suppression mechanism.Öğe Exploring menopause from a multidisciplinary perspective: Biology, psychosocial factors, and clinical insights(Nova Science Publishers, Inc., 2024) Yurtcu, Nazan; Karademir, Dilay; Durmusoglu, FatihMenopause is a period of life, just like infancy, puberty, and sexual maturity. During menopause, the amount of follicles in the ovariesdecreases and with that estrogen production decreases. Over time, estrogen production ceases and the ovaries shrink. Accordingly, the menstrual cycle is interrupted and reproductive ability is lost. The word menopause derives from the Greek words mens (month) and pause (stop). The World Health Organization defines menopause as the permanent cessation of the menstrual cycle as a result of the ovaries losing their activity. This book provides an up-to-date perspective on the management of clinical conditions that can occur in the premenopausal and postmenopausal period. The clinical symptoms that affect all body systems during this period in the woman's life and the possible concerns about how to face it, as well as clinical approaches are discussed. It aims to better understand these clinical situations and to offer correct solutions in approaching these problems. It also focuses on the potential impact of preventive medicine on improving women's health and quality of life. It covers a wide range of topics such as fertility, climacteric and menopausal symptoms, breast disease, psychosomatic conditions, genitourinary health, bone health, and the physiopathology and treatments of many clinical conditions, especially in premenopausal and premenopausal women. This book, which covers all aspects of menopause and aims to provide up-to-date information on its management, will be an invaluable resource for gynecologists, endocrinologists and doctors. © 2024 by Nova Science Publishers, Inc. All rights reserved.Öğe Formoterol, beta-2 selektif agonist ve BRL 37344, beta-3 selektif agonistin term gebe sıçan myometrium üzerine invitro etkileri(Cumhuriyet Üniversitesi, 2004) Yurtcu, Nazan; Çetin, AliIV FORMOTEROL, BETA-2 SELEKTIF AGONIST VE BRL 37344, BETA-3 SELEKTİF AGONÎSTİN TERM GEBE SIÇAN MYOMETRİUMU ÜZERİNE İN VİTRO ETKİLERİ ÖZET Bu çalışmanın amacı beta-2 agonist formoterol ile beta-3 agonist etkili BRL 37344'ün izole myometrial dokular üzerine tokolitik etkilerini karşılaştırmaktır. Ayrıca formoterol ve BRL 37344'ün myometrial dokularda siklik adenozin monofasfat (cAMP) ve siklik guanozin monofosfat (cGMP) düzeyine etkilerini inceleyip karşılaştırdık. Term gebelik dönemlerindeki Wistar albino sıçanlardan (n=12) elde edilen izole myometrial şeritler üzerinde formoterol (KT^-IO^M) ve BRL 37344'nin (10"1-10-6M) izometrik gerilimleri kaydedildi. Oksitosin ile uyarılmış sıçan myometriumunda gevşetici etkileri gözlendi. Daha sonra doku banyo deneyleri beta-1, beta-2 ve beta-3 antagonisler (metoprolol, ICI 118551 ve SR 59230A (lO^M) sırasıyla) varlığında gevşetici etkilerini araştırmak amacıyla tekrarlandı. Formoterol ve BRL 37344'nin izole myometrial dokularda cAMP and cGMP düzeylerine etkileri, radioimmunoassay kitleri kullanılarak ölçüldü. Her iki ilacında doza bağlı olarak tüm şeritlerdeki myometrial kasılmalar üzerine gevşetici etkileri görüldü (Emax=100% ve 70.6% sırayla). Formoterol Emax değeri BRL 37344'ün Emax değerinden anlamlı olarak daha yüksekti P<0.05), fakat pÜ2 değerleri arasında (9.54±0.12 ve 9.12±0.12 sırasıyla) anlamlı bir fark yoktu. ICI 118551 myometrial şeritler üzerindeki formoterolün gevşetici etkisini antagonize ederken, metoprolol veya SR 59230A antagonize etmedi. SR 59230A myometrial şeritler üzerindeki BRL 37344'ün gevşetici etkisini antagonize ederken, metoprolol veya ICI 118551 antagonize etmedi. Her iki ilaç cAMP düzeylerini anlamlı olarak yükselttiler p<0.05). Her iki ilaç myometrial kasılmaları benzer güçte azaltırken formoterolün etkinliği BRL 37344'den daha fazlaydı. Her iki ilacın erken doğum eylemindeki klinik etkinliği ve yan etkileri daha kapsamlı in vivo kontrollü araştırmalarla belirlenmesi gereklidir. Anahtar kelimeler: Formoterol, BRL 37344, Myometrium, cAMP, cGMP, Sıçan.Öğe Metabolomics in the diagnosis of pregnancy complications(Nova Science Publishers, Inc., 2023) Yurtcu, Nazan; Karademir, DilayThe pregnancy process is an intricate and unique period that requires control examinations to ensure the continuity of the well-being of the mother and the baby. The accompanying changes are also evident biologically, physiologically, psychologically, and socially. Several factors must be considered to determine when a woman's pregnancy is at risk and when unfavorable pregnancy outcomes will occur. Biomedical indicators are critical in medicine. Studies show that the variables in these indicators are vital in determining the risk status. Once the metabolic pathways are understood clearly in healthy and diseased conditions, we can gain more applicable information on disease mechanisms and precise treatment approaches. The prenatal medicine practices require the development of novel non-invasive approaches that cover diverse categories of diseases with lower rates of false-positives. Metabolomics for this purpose has the potential of great advantage. Metabolomic studies measure and analyze the biochemistry products of cells. As a biomarker, metabolomics may uncover new diagnostic and therapeutic approaches. This chapter reviews the idea and utilization of metabolomics for maternal health and perinatal medicine, emphasizing the latest developments in metabolomics studies and the research agenda. In addition, the existence of studies that will increase our knowledge about the etiopathogenesis of maternal complications is exciting and promising. © 2023 Nova Science Publishers, Inc. All rights reserved.Öğe Predictive value of pregnancy of follicular fluid fetuin-A and -B levels in infertile women after intra-cytoplasmic sperm injection(Wiley, 2022) Yurtcu, Nazan; Oral, Serkan; Celik, Sebahattin; Caliskan, Suleyman Tumer; Alagoz, Murat; Dahan, Michael H.Aim We aimed to investigate the value of follicular fluid fetuins-A and -B to predict successful IVF and pregnancy outcomes in infertile women with poor, normal, and high ovarian reserve. Methods The follicular fluid of 96 infertile women who underwent intra-cytoplasmic sperm injection (ICSI) procedure was analyzed. Fetuins-A and -B levels were examined and compared in those who could achieve pregnancy and those who could not. Receiver operating characteristic curve analyzes were used to determine cut-off and statistically significant associations for fetuins-A and -B. Results Follicular fluid fetuin-A levels were higher in cases with weak ovarian reserve (OR) (p < 0.05) and higher in patients who did not achieve clinical pregnancy (p < 0.05). Conversely, the follicular fluid fetuin-B levels were lower in cases with poor OR (p < 0.05) and were lower in patients who did not achieve a clinical pregnancy (p < 0.05). A follicular fluid fetuin-A concentration <= 19.12 ng/mL had a sensitivity and specificity of 94.74% and 93.1%, respectively, at predicting clinical pregnancy. While the follicular fluid fetuin-B concentration >24.7 ng/mL had sensitivity and specificity of 71.1% and 51.7%, respectively, for clinical pregnancy prediction. Conclusion Overall, high levels of follicular fluid fetuin-A may be independently associated with unsuccessful IVF irrespective of OR grouping. A low level of follicular fetuin-B was also associated with failed IVF. The sensitivity and specificity were found to be higher for fetuin-A in predicting clinical pregnancy. Therefore, the follicular fluid fetuin-A may be more predictive for successful IVF and clinical pregnancy outcomes than follicular fluid fetuin-B.Öğe Predictive value of pregnancy of follicular fluid fetuin-A and-B levels in infertile women after intra-cytoplasmic sperm injection(2021/12) Yurtcu, NazanAimWe aimed to investigate the value of follicular fluid Fetuins-A and -B to predict successful IVF and pregnancy outcomes in infertile women with poor, normal, and high ovarian reserve. MethodsThe follicular fluid of 96 infertile women who underwent intra-cytoplasmic sperm injection (ICSI) procedure was analyzed. Fetuins-A and -B levels were examined and compared in those who could achieve pregnancy and those who could not. ROC curve analyzes were used to determine cut-off and statistically significant associations for fetuins-A and -B.ResultsFollicular fluid Fetuin-A levels were higher in cases with weak ovarian reserve (OR) (p<0.05) and higher in patients who did not achieve clinical pregnancy (p<0.05). Conversely, the follicular fluid Fetuin-B levels were lower in cases with poor OR (p<0.05) and were lower in patients who did not achieve a clinical pregnancy (p<0.05). A follicular fluid Fetuin-A concentration ≤19.12 ng/mL had a sensitivity and specificity of 94.74% and 93.1%, respectively, at predicting clinical pregnancy. While the follicular fluid Fetuin-B concentration >24.7 ng/mL had sensitivity and specificity of 71.1% and 51.7%, respectively, for clinical pregnancy prediction.ConclusionsOverall, high levels of follicular fluid Fetuin-A are independently associated with unsuccessful IVF irrespective of OR grouping. A low level of follicular Fetuin-B was also associated with failed IVF. The sensitivity and specificity were found to be higher for Fetuin-A in predicting clinical pregnancy. Therefore, the follicular fluid Fetuin-A may be more predictive for successful IVF and clinical pregnancy outcomes than follicular fluid Fetuin-B.Trial registration: This trial was registered at ClinicalTrials.gov as NCT04201847.Öğe Preface(Nova Science Publishers, Inc., 2024) Aslan, Adem; Yurtcu, Nazan; Güler, Mustafa Can[No abstract available]Öğe Preface(Nova Science Publishers, Inc., 2024) Yurtcu, Nazan; Karademir, Dilay[No abstract available]Öğe Öğe Pregnancy Induced Autoimmune Diseases(18/05/2021) Yurtcu, NazanAutoimmune diseases have been seen in approximately 8% of the population, and about 80% of these patients are women (Fairweather and Rose 2004). The interaction between autoimmunity and reproduction has two sides. On the one hand, pregnancy may cause de novo autoimmune diseases, especially after pregnancy; and on the other hand, pregnancy may change the course of autoimmune disease regarding its severity and exacerbations (Borchers et al. 2010). After vaginal or cesarean deliveries, and induced abortion, maternal risk of autoimmune disease development is increased and continues to have increased incidence in post-reproductive years (Bianchi et al. 1996). Considering the clinical similarities of chronic graft-versus-host disease and the complex nature of autoimmunity manifested by some autoimmune diseases; persistent fetal microchimerism, the maternal acquisition of intact cells of fetal origin without any apparent rejection may play a role in autoimmune disorders (Shrivastava et al. 2019). Microchimerism is a common phenomenon going on with the presence of genetically distinct cells in the individual and can be seen in 70% of healthy women. Although microchimerism probably occurs in small quantities, microchimeric cells have remarkable effects on women's health (Gammill and Nelson 2010). Fetal microchimerism as a phenomenon was hypothesized to be responsible for the de novo autoimmune diseases’ occurrence; however, published data regarding the pregnancy-related autoimmune diseases are still controversial and debated. This chapter discusses pregnancy-induced autoimmunity and its effects on women's health in the light of studies investigating microchimerism and related conditions.Öğe Serum Melatonin as a Biomarker for Assessment of Late-term and Postterm Pregnancies in Women without Spontaneous Onset of Labor(Georg Thieme Verlag KG, 2021/12) Yurtcu, Nazan; Çalışkan, Canan; Çelik, SamettinWe conducted a prospective study to assess serum melatonin as a biomarker to predict the development of late-term and postterm pregnancies and spontaneous beginning of labor in women with term pregnancies. Population of this prospective study included pregnant women with late-term and postterm pregnancies and term pregnancies as controls. In these study groups, serum melatonin concentrations were measured in women with or without labor and their perinatal data were collected. In the postterm pregnancies without labor, the lowest median melatonin concentrations were measured (p<0.05). In the late-term and postterm pregnancies with and without labor, the median serum melatonin concentrations were significantly lower than term ones (p<0.05). In the term pregnancies with labor, the highest median melatonin concentration was measured (p<0.05). A serum melatonin concentration≤34 pg/mL as a cut-off value determines late-term and postterm pregnancy with a sensitivity of 80.4% and a specificity of 81.4%. A serum melatonin concentration>29.35 pg/mL as a cut-off value determines presence of labor with a sensitivity of 82.1% and a specificity of 55.0%. In women with term pregnancies, with the measurement of serum melatonin, it is possible to predict the development of late-term and postterm pregnancies and whether these pregnancies undergo spontaneous labor. With further studies, these findings need to be supported before their routine clinical use.Öğe The combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans(Frontiers Media Sa, 2024) Berk, Seyda; Cetin, Ali; Ozdemir, Ozgur Ulkue; Pektas, Ayse Nur; Yurtcu, Nazan; Dastan, Sevgi DurnaIntroduction Sedentary lifestyles and diets with high glycemic indexes are considered to be contributing factors to the development of obesity, type 2 diabetes in humans. Metformin, a biguanide medication commonly used to treat type 2 diabetes, has been observed to be associated with longevity; however, the molecular mechanisms underlying this observation are still unknown.Methods The effects of metformin and high glucose, which have important roles in aging-related disease such as diabetes and cancer, were studied in lin-35 worms because they are associated with cancer-associated pRb function in mammals and have a tumour suppressor property.Results and Discussion According to our results, the negative effect of high glucose on egg production of lin-35 worms was greater than that of N2 worms. High glucose shortened lifespan and increased body length and width in individuals of both strains. Metformin treatment alone extended the lifespan of N2 and lin-35 worms by reducing fertilization efficiency. However, when metformin was administered in the presence of high glucose, the lifespan of lin-35 worms was clearly longer compared to N2 worms. Additionally, we conclude that glucose and metformin in lin35 worms can extend life expectancy through a DAF-16/FOXO-independent mechanism. Furthermore, the results of this study will provide a new perspective on extending mammalian lifespan through the model organism C. elegans.Öğe THERAPEUTIC POTENTIAL OF MicroRNAs IN PREGNANCY-RELATED DISORDERS(27/05/2021) Yurtcu, NazanmiRNAs reveal irregular expressions in women with pregnancy complications (Bogdanet et al., 2021; Memtsa et al., 2019; Rana et al., 2020). Further research is required to further define an individual miRNA as a biomarker in placental disorders. Checking for disorganized placental and circulatory miRNAs is necessary in large-scale preclinical studies. According to the literature, generally, large-scale clinical trials should be planned to evaluate the clinical significance of circulating miRNAs in pregnancy-related conditions. This is important, since it will help determine their sensitivity and specificity for inclusion in clinical diagnostics and follow-up tests. Considering the multiple factors influencing the growth of pregnancy, it appears likely that a panel of various biomarkers, including genomic, transcriptomic, proteomics, and biophysical ones, combined with maternal characteristics, can be utilized to make better the health care for pregnant women in the future.
