Synthesis and Characterization of Novel Benzimidazolium Type NHC Molecule and Its Silver Complex and Their Theoretical Analysis for Potential Anti-Cancer Activity

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dc.contributor.authorÜstün, Elvan
dc.contributor.authorŞahin, Neslihan
dc.date.accessioned2024-10-26T17:41:16Z
dc.date.available2024-10-26T17:41:16Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractN-heterocyclic carbenes have initially attracted great attention of the chemists in consequence of their catalytic activity. The favorable results were also obtained in bioactivity studies for N-heterocyclic carbenes, and their transition metal complexes in following years. Theoretical methods deliver beneficial data about the several activities of molecules. One of them is the frontier orbital analysis, which supplies data about the reactivity of molecules. Another method is investigation of the molecular activity against crystals of certain macromolecules using molecular docking methods. In this study, novel 1-allyl-3-(cyclohexylmethyl)benzimidazoliumbromide and bromo[1-allyl-3-(cyclohexylmethyl)benzimidazolium-2-ylidene]silver(I) were synthesized and characterized. The characterizations were also supported by spectroscopical and theoretical methods. In order to have foresight about the bioactivities of these molecules, molecular docking methods were used to get information about the interactions between molecules and VEGFR-2, which regulates the angiogenesis, and DNA.
dc.identifier.doi10.31466/kfbd.1186972
dc.identifier.endpage287
dc.identifier.issn2564-7377
dc.identifier.issue2
dc.identifier.startpage275
dc.identifier.trdizinid1181610
dc.identifier.urihttps://doi.org/10.31466/kfbd.1186972
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1181610
dc.identifier.urihttps://hdl.handle.net/20.500.12418/24401
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKaradeniz Fen Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDFT
dc.subjectMolecular Docking
dc.subjectN-Heterocyclic Carbenes
dc.subjectVGEFR-2
dc.subjectSilver Molecules
dc.titleSynthesis and Characterization of Novel Benzimidazolium Type NHC Molecule and Its Silver Complex and Their Theoretical Analysis for Potential Anti-Cancer Activity
dc.typeArticle

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