Investigation of the Analgesic Properties L-759,633 and SER 601 in Experimental Neuropathic Pain Model in Rats and their Comparison with Pregabalin

Basit Öğe Kaydı
dc.contributor.authorJoha, Ziad
dc.contributor.authorYıldırım, Sahın
dc.contributor.authorHacısüleyman, Levent
dc.contributor.authorTaşkıran, Ahmet Şevki
dc.date.accessioned2024-10-26T17:33:58Z
dc.date.available2024-10-26T17:33:58Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractDespite the fact that narcotics and NSAIDs are the mainstays of nociceptive pain care, only a small proportion of neuropathic pain patients benefit from them. Cannabinoid agents could be a viable alternative to opioids in the management of chronic pain. The goal of our investigation was to assess the analgesic efficacy of SER 601 and L-759,633, cannabinoid receptor 2 (CB2) agonists, at various doses in a model of neuropathic pain generated in rat. The analgesic effect of CB2 agonists L-759,633 and SER 601 at various doses in a rat model of neuropathic pain created by partial sciatic nerve ligation was examined by the hot plate method. Furthermore, a comparison of analgesic effects of both drugs with pregabalin is also conducted. The two substances demonstrated a dose-dependent analgesic effect in this model. The analgesic response of SER601 and L-759,633 in the neuropathic pain model was higher compared to that of pregabalin. All in all, our data suggest that SER601 and L-759,633 may offer a beneficial treatment option for neuropathic pain in future.
dc.identifier.doi10.17776/csj.1060972
dc.identifier.endpage45
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1
dc.identifier.startpage41
dc.identifier.trdizinid1162880
dc.identifier.urihttps://doi.org/10.17776/csj.1060972
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1162880
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23440
dc.identifier.volume44
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeuropathic pain
dc.subjectL-759
dc.subject633
dc.subjectSER 601
dc.subjectHot plate
dc.subjectPregabalin.
dc.titleInvestigation of the Analgesic Properties L-759,633 and SER 601 in Experimental Neuropathic Pain Model in Rats and their Comparison with Pregabalin
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu