Investigation of Antiepileptic and Anticancer Properties of Some Plant Species Traditionally Used in Turkey

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dc.contributor.authorOzpinar, Hulya
dc.contributor.authorBostanci, Hayrani Eren
dc.contributor.authorHurmet, Melahat
dc.contributor.authorKocyigit, Umit Muhammet
dc.date.accessioned2024-10-26T17:53:15Z
dc.date.available2024-10-26T17:53:15Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe study investigated the antiepileptic and anticancer properties of water and ethanol extracts from plant species traditionally used in Turkey, including Centaurea solstitialis subsp. solstitialis (CSS), Tragopogon reticulatus (TR), Erodium cicutarium subsp. cicutarium (ECC), Alyssum alyssoides (AA) and Leontice leontopetalum subsp. leontopetalum (LLL) using apoptosis and cell cycle studies. In the investigation of the antiepileptic properties of plant extracts, the effects on the activities of carbonic anhydrase I and II isoenzymes were measured spectrophotometrically. In anticancer studies, all extracts were applied to human stomach cancer cell line (AGS), human breast cancer cell line (MCF7) and rat glioma cell line (C6) and their cytotoxicity in healthy mouse fibroblast cell line (L929) was compared using the MTT method. All extracts of ECC inhibited carbonic anhydrase I and II isoenzymes at lower concentrations than the standard substance. However, aqueous extracts of all plants had a highly toxic effect on rat glioma cell line (C6), without damaging healthy cells. © 2024, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.
dc.identifier.endpage625
dc.identifier.issn0326-2383
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85191434185
dc.identifier.scopusqualityQ4
dc.identifier.startpage618
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26817
dc.identifier.volume43
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherColegio de Farmaceuticos de la Provincia de Buenos Aires
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlyssum alyssoides; Centaurea solstitialis; Erodium cicutarium; Leontice leontopetalum; Tragopogon reticulatus
dc.titleInvestigation of Antiepileptic and Anticancer Properties of Some Plant Species Traditionally Used in Turkey
dc.typeArticle

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