Lifespan extension with mTOR inhibitors rapamycin, everolimus, and temsirolimus in Caenorhabditis elegans (Maupas, 1899)

Basit Öğe Kaydı
dc.contributor.authorDemirel, Tugba
dc.contributor.authorOzdemir, Ozgur Ulku
dc.contributor.authorBerk, Seyda
dc.date.accessioned2024-10-26T18:03:44Z
dc.date.available2024-10-26T18:03:44Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractA master regulator of longevity in all eukaryotes, the mechanistic target of rapamycin signalling pathway (mTOR) is thought to mediate certain effects of dietary restriction. The tumour suppressor pRb , whose orthologue in Caenorhabditis elegans is lin-35/pRb , is predicted to be involved in almost all human cancers. As lin-35 is linked to cancer -associated pRb function in mammals and also has a tumour suppressor effect by inhibiting mTOR signalling, the lin-35 was included in the study to investigate the effects of mTOR inhibitors. We showed that mTOR inhibitors extended the lifespan of N2 and lin-35 C. elegans by reducing fertilisation efficiency and resulted in reductions in the body size of worms. Additionally, rsks-1/S6K and let-363/TOR expressions increased in the presence of rapamycin, temsirolimus, or everolimus. The elucidation of molecular mechanisms of rapamycin and its analogues regulating health prolonging will expand their therapeutic applicability in treatment of human aging and age -related disorders.
dc.description.sponsorshipAdvanced Technology and Research Center (CUTAM); Sivas Cumhuriyet University; Sivas Cumhuriyet University Scientific Research Projects (CUBAP) [F-2021-652]
dc.description.sponsorshipThe authors are thankful for the ongoing support of the Advanced Technology and Research Center (CUTAM) , Sivas Cumhuriyet University. Further, we would like to thank & Idot;lknur Duman, Hale Sultan Bayram, Rabia Kaleli and Beyzanur Ba & scedil;y & imath;ld & imath;z, senior students of the Department of Molecular Biology and Genetics at Sivas Cumhuriyet University, for providing the necessary convenience and encouragement for the maintain of the C. elegans culture. The results presented here basically originated from Mrs Tugba Demirel's M.Sc. thesis, which is financially supported by Sivas Cumhuriyet University Scientific Research Projects (CUBAP) (Grant No. F-2021-652) .
dc.identifier.doi10.24412/0869-6918-2024-1-15-30
dc.identifier.endpage30
dc.identifier.issn0869-6918
dc.identifier.issue1
dc.identifier.startpage15
dc.identifier.urihttps://doi.org/10.24412/0869-6918-2024-1-15-30
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28542
dc.identifier.volume32
dc.identifier.wosWOS:001228881200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherRussian Acad Sci, Inst Parasitology
dc.relation.ispartofRussian Journal of Nematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectageing
dc.subjectCaenorhabditis elegans
dc.subjectcancer
dc.subjectfertilisation
dc.subjectlin-35
dc.subjectlongevity
dc.titleLifespan extension with mTOR inhibitors rapamycin, everolimus, and temsirolimus in Caenorhabditis elegans (Maupas, 1899)
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu