Anticancer Effects of Urtica Dioica in Breast Cancer

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dc.contributor.authorKarakol, Percin
dc.contributor.authorSaraydin, Serpil Unver
dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorInan, Zeynep Deniz Sahin
dc.contributor.authorTuran, Mustafa
dc.date.accessioned2024-10-26T17:52:51Z
dc.date.available2024-10-26T17:52:51Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The goal of this study is to look into the antiproliferative capabilities of Urtica Dioica (UD) on breast cancer. Methods: The cytotoxicity of UD extracts against breast cancer cell lines was investigated. Flow cytometry analyses were used to investigate in vitro apoptosis of breast cancer cells using Annexin V labeling. In vivo tests also performed. Results: UD showed cytotoxicity to three cancer cell lines. The number of Annexin-positive cells was higher in UD-treated cell lines than in untreated control cells. When compared to the untreated control group, the rats treated with UD had greater expressions of caspase 3, p53 protein, and TUNEL positive cells. When compared to the control group, Ki-67 expression was reduced in the treatment groups. In vivo tests revealed that, when compared to untreated rats, the mean tumor volume inhibition ratio in the UD group was 38 percent. Conclusion: These findings suggest that Urtica Dioica may have antitumoral properties in the treatment of breast cancer. © 2022, Asian Pacific Journal of Cancer Prevention. All rights reserved.
dc.identifier.doi10.31557/APJCP.2022.23.2.673
dc.identifier.endpage681
dc.identifier.issn1513-7368
dc.identifier.issue2
dc.identifier.pmid35225481
dc.identifier.scopus2-s2.0-85125428781
dc.identifier.scopusqualityQ3
dc.identifier.startpage673
dc.identifier.urihttps://doi.org/10.31557/APJCP.2022.23.2.673
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26567
dc.identifier.volume23
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer; Breast cancer; Cytotoxicity; In vitro; Urtica dioica
dc.titleAnticancer Effects of Urtica Dioica in Breast Cancer
dc.typeArticle

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