Effects of Lactobacillus Rhamnosus on dental implant osseointegration in osteoporotic rabbit model

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dc.contributor.authorSaygin, Aysegul Goze
dc.contributor.authorGorler, Oguzhan
dc.contributor.authorYildirim, Ali
dc.contributor.authorErcan, Nazli
dc.contributor.authorGoze, Omer Fahrettin
dc.date.accessioned2024-10-26T18:05:44Z
dc.date.available2024-10-26T18:05:44Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim: The effect of Lactobacillus rhamnosus (LR), probiotic bacteria that manage inflammatory disease, on osseointegration is unknown. The study aimed to evaluate the effects of LR administration on osseointegration in experimental osteoporosis induced by ovariectomy. Material and Methods: Sixteen New Zeland female rabbits were randomly divided into the following groups: SHAM (SH), SHAM and LR (SH+LR), Ovariectomy (OVX), OVX and LR (OVX+LR). Animals in the OVX group were subjected to bilateral ovariectomy to create artificial osteoporosis. After 16 weeks, a titanium dental implant was bilaterally implanted into each tibia of the animals. Animals in the SH+LR and OVX+LR groups were given oral probiotics. All animals were sacrificed and all tibia bones were separated at postoperative 8 weeks after implantation. Cardiac blood was taken to determine biochemical markers. Resonance frequency analysis (RFA) and bone-to-implant contact area (BIC) were administered. Results: RFA and BIC area were statistically significant for osseointegration in OVX+LR compared with OVX (p<0.05). The BIC area in the OVX group was statistically lower (p<0.05). ALP, BALP, Trap5b and MPO were highest in OVX groups(p<0.05). Discussion: This study concluded that osseointegration may be improved by LR administration in an estrogen-deficient state. The success rate of the implant may be increased by using probiotics in patients with osteoporosis.
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [DIS-203]
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Cumhuriyet University under project number DIS-203.
dc.identifier.doi10.4328/ACAM.20467
dc.identifier.endpage854
dc.identifier.issn2667-663X
dc.identifier.issue8
dc.identifier.startpage850
dc.identifier.urihttps://doi.org/10.4328/ACAM.20467
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29163
dc.identifier.volume12
dc.identifier.wosWOS:000740774500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry
dc.subjectHistomorphometry
dc.subjectLactobacillus Rhamnosus
dc.subjectOsseointegration
dc.subjectOsteoporosis
dc.subjectProbiotics
dc.titleEffects of Lactobacillus Rhamnosus on dental implant osseointegration in osteoporotic rabbit model
dc.typeArticle

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