The Effect of Plantain Active Ingredient Aucubin on Isolated Rat Smooth Muscle Tissue and Primary Cell Lines
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Tarih
2020
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Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aims to assess the pharmacodynamics of aucubin, the active ingredient in plantain (Plantago), in vitrorat bladder and trachea tissues, and explore its cell protective effects on primary lung and kidney cell lines. The study wascarried out by repeated applications of acetylcholine, atropine, verapamil and oxybutynin, alongside Ca ++ in a calcium-freeenvironment, on urinary bladder tissue, and repeated applications of acetylcholine, atropine, carbachol and mecamylamineon trachea tissue. At the same time, cell viability and catalase and superoxide dismutase activities was measured in primarycell lines. The results indicated that aucubin had a relaxant effect on urinary bladder and trachea tissues. It was conceivedthat aucubin acted as a cholinergic antagonist through different subreceptors (muscarinic-3 receptors). The results alsoindicated that aucubin caused a statistically insignificant increase in remaining at the level of the control group in cellviability in the primary lung and kidney cell lines at increasing concentrations (1-10 µM), while causing a significant reducein cell viability at 20 and 50 µM concentrations in the same cell lines. In conclusion, it is suggested that plantain, which isused in folk medicine, and its active ingredient aucubin might have beneficial effects on bronchoconstriction and otherrespiratory conditions, as well as on pulmonary and renal diseases, urinary incontinence, etc
Açıklama
Anahtar Kelimeler
Kaynak
Harran Üniversitesi Veteriner Fakültesi Dergisi
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Scopus Q Değeri
Cilt
9
Sayı
1
