Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease

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dc.contributor.authorGökçen, Pınar
dc.contributor.authorÇakmak, Erol
dc.contributor.authorAdalı, Gupse
dc.contributor.authorDoğan, Halef Okan
dc.contributor.authorÖzer, Hatice
dc.contributor.authorOzturk, Oguzhan
dc.contributor.authorDoğanay, Hamdi Levent
dc.date.accessioned2024-10-26T17:41:15Z
dc.date.available2024-10-26T17:41:15Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: Non-invasive tests used in the screening and follow-up of celiac disease (CD) are currently below expectations because they show false negatives/positives and are not always correlated with duodenal histology. We aimed to investigate the predictive value of intestinal free fatty acid binding protein (FABP-I) which can easily be released into the circulation in the presence of enterocyte damage in a short time in CD. Methods: This study included 59 patients with CD who were not on gluten free diet (GFD)(n=24) and who were on GFD(n=35) and 52 healthy controls. Demographic variables, complete blood count, ferritin, vitamin D, calcium, phosphorus, vitamin B12, prothrombin time, INR, and serum FABP-I levels were recorded for all groups. Results: There was no difference between the groups in terms of complete blood count, ferritin, calcium, phosphorus, vitamin B12, prothrombin time and INR (all p>0.05). Mean serum FABP-I was determined as 499.2±33.3 ng/L for patients with CD who were not on GFD and as 487.7±48.0 ng/L for who were on GFD, and these values were significantly higher when compared to the healthy controls 432.2±63.8 ng/L(p<0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of FABP-I for a cut-off value of 456.8 ng/L were 84.7%, 69.2%, 10.2% and 61.5%, respectively(AUC=0.785). Conclusion: This study has shown that FABP-I can serve as a non-invasive predictive marker for CD diagnosis. Overlooked diagnosis in serology-negative patients and false serology positivity for reasons other than CD will be prevented with its use in clinical practice since FABP-I directly reflects intestinal damage.
dc.identifier.doi10.31067/acusaglik.979140
dc.identifier.endpage35
dc.identifier.issn1309-470X
dc.identifier.issn1309-5994
dc.identifier.issue1
dc.identifier.startpage30
dc.identifier.trdizinid482869
dc.identifier.urihttps://doi.org/10.31067/acusaglik.979140
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/482869
dc.identifier.urihttps://hdl.handle.net/20.500.12418/24372
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAcıbadem Üniversitesi Sağlık Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePredictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease
dc.typeArticle

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