A significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndrome

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dc.contributor.authorKAYDOK, Ercan
dc.contributor.authorÖzmen, Esma
dc.contributor.authorSARI, İsmail
dc.contributor.authorŞEN CAKIROĞLU, Gözde
dc.contributor.authorTAŞ, Ayça
dc.contributor.authorSİLİĞ, Yavuz
dc.contributor.authorHAYTA, Emrullah
dc.date.accessioned2023-06-22T10:48:00Z
dc.date.available2023-06-22T10:48:00Z
dc.date.issued2022tr
dc.departmentTıp Fakültesitr
dc.description.abstractFibromyalgia syndrome (FMS) is a multifactorial disease characterized by chronic diffuse pain. Genetic factors are also involved in the etiology. However, there is not enough information on the genetic factors that play a role in the pathogenesis of FMS. This study aims to investigate the relationship between estrogen receptor 1 gene (ESR1) 594G>A (rs2228480) and 325C>G (rs2295190) polymorphisms and FMS. A total of 294 women, 146 of who were FMS patients and 148 of whom were healthy controls, were enrolled in the study. The instruments used to collect data from patients included patient follow-up forms, Visual Analog Scale (VAS), and Fibromyalgia Impact Questionnaire (FIQ). Genotyping of ESR1 594G>A and 325C>G polymorphisms in the extracted DNA samples was performed using an RT-PCR device and TaqMan hydrolysis probes. It was found that, for rs2295190 polymorphism, patients with CG and GG genotypes versus CC genotypes showed a decreased risk for FMS (OR: 0.442; 95% CI: 0.234-0.833). But there were no significant differences were found in the genotype distribution of rs2228480 polymorphism between the FMS patients and controls. The intragroup evaluation of FMS patients revealed no significant association between symptoms, pain score, FIQ score, and polymorphisms (p>0.05). We believe that there is a significant association between ESR1 rs2295190 polymorphism and FMS and that this polymorphism may be protective against FMS. However, there is a need for comprehensive studies on different populations to obtain clearer data as well as further studies to elucidate the possible mechanism of association.tr
dc.description.sponsorshipThis study was supported by the Scientific Research Project Fund of Nigde Ömer Halisdemir University (Project No: 2019/4-BAGEP).tr
dc.identifier.doi10.14715/cmb/2022.68.7.30en_US
dc.identifier.endpage187tr
dc.identifier.issue7tr
dc.identifier.pmid36495498en_US
dc.identifier.scopus2-s2.0-85143917630en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage182tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13945
dc.identifier.volume68tr
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCMB Association Publihertr
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectFibromyalgiatr
dc.subjectEstrogen receptor 1tr
dc.subjectPolymorphismtr
dc.subjectSymptomtr
dc.subjectPaintr
dc.titleA significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndromeen_US
dc.typeArticleen_US

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