BIOLOGICAL EVALUATION OF 1-(4-(HYDROXY(1-OXO-1,3-DIHYDRO-2H-INDEN-2-YLI-DENE)METHYL)PHENYL)-3-PHENYLUREA DERIVATIVES: ANTICHOLINERGICS AND ANTIEPILEPTIC POTENTIALS

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dc.contributor.authorKocyigit, Umit Muhammet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:17Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:17Z
dc.date.issued2019
dc.department[Kocyigit, Umit Muhammet] Sivas Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkeyen_US
dc.description.abstractIn this work, a class of phenylurea compounds containing 2-benzoylindan-1-one molecules 3a-3j was designed and synthesized from the reaction of phenylurea-substituted acetophenone compounds with phthalaldehyde molecule under mild action situations in good yields. The inhibitory effect of these compounds on some metabolic enzymes was examined and compared with a standard compound. IC50 values were obtained from the phenylurea-Induced Activity (%)-[phenylurea compounds] graph and from the Lineweaver-Burk graph. According to the results, the IC50 values of these molecules were in the range 18.23-63.01 nM for hCA I, while the mean K-i values were in the range 7.79 +/- 0.94-122.64 +/- 32.15 nM for this enzyme. The results obtained are expected to make an important contribution to drug design and pharmacological applications. Additionally, these compounds demonstrated well inhibitory effects against acetylcholineesterase (AChE) enzyme. Finally, the K-i values of hCA II were in the range 15.09 +/- 4.48-65.72 +/- 6.64 nM and 1.54 +/- 0.21-22.44 3.83 nM against AChE, respectively.en_US
dc.identifier.endpage2746en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4en_US
dc.identifier.startpage2739en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6014
dc.identifier.volume28en_US
dc.identifier.wosWOS:000465645700047en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPARLAR SCIENTIFIC PUBLICATIONS (P S P)en_US
dc.relation.ispartofFRESENIUS ENVIRONMENTAL BULLETINen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhenylureaen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectenzyme inhibitionen_US
dc.subjectantiepileptic potentialsen_US
dc.titleBIOLOGICAL EVALUATION OF 1-(4-(HYDROXY(1-OXO-1,3-DIHYDRO-2H-INDEN-2-YLI-DENE)METHYL)PHENYL)-3-PHENYLUREA DERIVATIVES: ANTICHOLINERGICS AND ANTIEPILEPTIC POTENTIALSen_US
dc.typeArticleen_US

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