Investigation of Antimicrobial and Cytotoxic Activities of Palmarosa (Cymbopogon martinii) Essential Oil

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dc.contributor.authorGürer, Eda Sönmez
dc.contributor.authorTunç, Tutku
dc.date.accessioned2024-10-26T17:33:59Z
dc.date.available2024-10-26T17:33:59Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study; It was aimed to investigate the cytotoxic activities and antimicrobial effects of Palmarosa essential oil obtained from Cymbopogon martinii plant. Content analyzes of Palmarosa essential oil were made by Gas Chromatopraphy-Mess Spectrometry (GS-MS). The antimicrobial effects of Palmarosa essential oil were investigated using Disk Diffusion and Minimum Inhibition Concentration (MIC) methods. Cytotoxic effects of essential oil at different concentrations in breast cancer (MCF-7), prostate cancer (DU-145) and healthy human fibroblast (WI-38) cell lines XTT (2,3-bis-(2-methoxy-4-nitro-5) -sulfophenyl)-2H-tetrazolium-5-carboxanilide) test. In the disc diffusion method of Palmarosa; against K. pneumoniae, S. aureus, and E. coli, it was observed that the first concentrations formed zone diameters very close to the standard. It has been determined that the antifungal effect against C. albicans is present in the first two concentrations (200-100 µg/mL). Palmarosa, in the MIC method; Showed the highest antibacterial effect against B. cereus (MIC: <1.56 µg/mL). It has reached effective MIC values against other bacteria and fungi. In our cytotoxic activity studies; The IC50 value for DU-145 cells was 3.14 ±0.126, 6.29 ±0.56 for MCF-7 and 20.06 ±1.02 for WI-38. The antitumor activity of Palmarosa essential oil was found to be more effective in DU-145 cells, but it was observed that there was no toxicity in WI-38 cell line.
dc.identifier.doi10.17776/csj.1149752
dc.identifier.endpage599
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue4
dc.identifier.startpage594
dc.identifier.trdizinid1149860
dc.identifier.urihttps://doi.org/10.17776/csj.1149752
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1149860
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23453
dc.identifier.volume43
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEssential oil
dc.subjectAntimicrobial
dc.subjectCytotoxicity
dc.subjectCymbopogon martinii
dc.titleInvestigation of Antimicrobial and Cytotoxic Activities of Palmarosa (Cymbopogon martinii) Essential Oil
dc.typeArticle

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